摘要:

Five cases of Infantile digital fibromatosis were described. Three were male and two were female. Multiple lesions were noted in two cases. The lesions were Intradermal and had a peculiar histologic pattern with intracytoplasmic inclusions. By electron microscopy, the inclusions were composed of a meshwork of both fibrils and fine granules and have no limiting membrane. No virus‐like particle could be identified in the proliferating cells. Follow‐up information was available in all five cases; one had recurring tum

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00844.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Cell differentiation in the fetal adrenal cortex of Spontaneously Hypertensive Rats (SHR, Okamoto and Aoki) and normotensive Wistar‐Kyoto Rats was studied histologically and histoautoradiographically at the 19th, 20th, 21st and 22nd day of gestation. The average body weight of the fetuses of SHR was statistically lower than that of the control fetuses but no significant differences were found in the adrenocortical histology. The labeling index of each fetal cortical zone of SHR on the 20th, 21st and 22nd day of gestation was significantly higher than that of normotensive control rats. Only the adrenals on the 19th day of gestation showed a higher labeling index In the control.The results of the present investigation suggest the close relationship between active cell proliferation and DNA synthesis of the adrenal cortex and functional stimulation of the anterior pituitary during the late embryonic life in SHR fetuse

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00845.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Eighteen autopsy cases which were intravenously administered with fat emulsion (Intrafat) during their clinical course are presented and analysed. The so‐called intravenous fat pigment was seen in the Kupffer cells of the liver, more or less, in ten cases forming brown granules of considerable variety in size, quantity, and quality. Besides, the same kind of granules were found in the cells of the reticulo‐endothelial system, systematically.An analytical study comparing their clinical data and microscopic findings was made. Histochemical and electron microscopical characteristics of the pigment were described, and possible mechanism of its deposition was also proposed. A part of the discussion was extended to the early change due to intravenous infusion of the

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00846.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Systemic hlstometrical and histological examinations of major skeletal muscles were performed by using autopsy cases with simple atrophy, neurogenic muscular atrophy, Duchenne type progressive muscular dystrophy, myositis of myasthenia gravis, and autopsy control cases. In hlstometrical studies, the shortest diameters of muscle fibers were measured and arranged in histograms. Volume ratio of stroma to muscle was measured by point‐counting method.Histometrical studies revealed the following results: (1) averages of muscle fiber diameters in controls showed the largest value In the muscles of the upper and lower extremities, and the smallest value in the lingual muscle; (2) in simple atrophy, neurogenic muscular atrophy, progressive muscular dystrophy and myositis, a decrease in muscle fiber diameters was more prominent in the muscles of the lower extremities than those of the upper extremities; (3) patterns of histograms of muscle fiber diameters were classified into six types, and in simple atrophy, almost one‐half of muscles examined belonged to type 3 histogram, which had the mode situated at a relatively small diameter and a not so high kurtosls; (4) volume ratios of stroma to muscle Increased most in both muscular dystrophy and long‐standing neurogenic muscular atrophy, moderately in myositis, and mildly in simple atrophy; and (5) hlstometrical changes In myasthenia gravis were mi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00847.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The fine structure of the three types of glomerular cells, especially glomerular epithelial cells was studied In experimental renal amyloidosis induced by both prolonged sensitization of focus antigens and casein.The presence of cytoplasmic invaginations which contained a bundle of amyloid fibrils in almost parallel array and intracytoplasmlc membrane‐surrounded amyloid fibrils were observed in the glomerular epithelial cells. They are quite comparable to those which were demonstrated in reticuloendothelial cells In other reports. The intracytoplasmlc invaginations opened at the plasma membrane either in the urinary space or in the basement membrane. By processing serial sections on the minimal deposition of amyloid, some of the Intracytoplasmlc membrane‐surrounded amyloid fibrils were found to be connected with parallel arrayed extracellular amyloid fibrils.Amyloid accumulated usually In large amount In mesangial matrix and along the basement membrane adjacent to the mesangium, but isolated depositions of amyloid, minimal though definite, were sometimes observed in the subepithelial and subendothelial areas, and in the epithelial cells far from the mesang

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00848.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

One hundred and fourty‐three cases of scirrhous cancer originating in the body of the stomach were examined histologically. The number corresponded to 4.2% of gastric cancer, 28.0% of scirrhous gastric cancers and 19.2% gastric cancers originating in the body of the stomach. From 30 to 60 years of age, there were twice as many female as male patients in every age decade.From gross appearances of the lesions, the scirrhous cancers were classified Into 1) Giant Fold Type and 2) Eroded Type. Both changes were seen, more or less, in the affected mucosae of all cases. The Giant Fold Type was seen mainly In the mucosa of the side walls or of the greater curvature, while the Eroded Type was more often seen In the mucosa of the lesser curvature or its neighboring area.Histologically, all cancerous lesions showed the picture of moderately or poorly differentiated adenocarcinoma with accompanying signet‐ring cells and evidence was obtained that the eroded or ulcerated area was the original site of the cancerisation. The giant folds resulted from reactive hyperplasia of the gastric mucosa to the diffuse intramural fibrosis caused by wide‐spread infiltration of the cancer cells. The cancerous foci of 42 cases of early cancer all showed a small erosion or shallow ulcer and were histologically composed of poorly differentiated adenocarcinoma. Scars which were covered by regenerating epithelia, were found in 4 cases, but these changes were thought to be secondary In n

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00849.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Three autopsied cases of so‐called neonatal necrotizing enterocolitis are reported here with a brief discussion on its pathogenesis.The three cases were all male, the age at death ranging from 5 days to 2 months. All the parents of the patients were in good health, and there was no abnormal history during pregnancy and delivery. The onset of illness was between the 4th and 46th day of life. Culture of the feces was done with two cases, one showingE, coliandEnterobacter,and the otherE. eollandPseudomonas aer.Multiple ulcers were seen, in the stomach down to the rectum in the 1st, in the duodenum to the rectum in the 2nd, and in the duodenum to the descending colon in the 3rd case. These ulcers were of various depths, and the ulcer‐floor was usually clean. Generally, the intestinall wall was thickened, hard, and frail. Histologically, the ulcers extended usually Into the submucosa, where slight to moderate Infiltration of lymphocytes, plasma cells, and histiocytes was seen. Occasionally the ulcers were found reaching the muscular layer, where phlegmonous inflammation was seen. The neural plexus of the intestinal wall was normal. All the cases were of malnutritional status.It seems to be reasonable to postulate its pathogenesis as a circulatory disorder based on some infectious process occurring in the intestinal tr

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00850.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

An autopsy case of glycogenosis type II (Pompe's disease) was reported. The case is that of the fourth autopsy of this type of glycogen storage disease, caused by acid maltase (α‐1, 4‐glucosidase) deficiency, in Japan. In addition to routine histopathological studies on skeletal muscle biopsy and autopsy, also were employed biochemical analyses of the enzyme activities in peripheral white blood cells and skeletal muscle, scoring method of a PAS‐positlve granule In circulating lymphocytes, and electron microscopic studies on muscle biopsy specimen, and cardiac muscle and liver obtained at autopsy. Cardiomegaly is one of the most significant clinical signs of the disease and biochemical measurement of the enzyme activity in cells or tissues is clinically of most diagnostic value. Gytological study by scoring PAS‐posltive granules in circulating lymphocytes is also of great value and is a simple method for aid in establishing a clinical diagnosis. Special attention should be paid to this case on the point of a tendency of thrombus formation and peripheral vascular disorder as complications of the disease, which caused aneurysm and thrombosis of the meningeal arteries and renal infarction, possibly due to degenerative process in the vascular medial smooth muscle cells by excessive deposition of

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb00851.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY