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1. |
Head trauma as a risk factor for Parkinson's disease |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 95-97
Matthew B. Stern,
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ISSN:0885-3185
DOI:10.1002/mds.870060202
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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2. |
Myoclonus inPapio papio |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 98-104
Simón Brailowsky,
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ISSN:0885-3185
DOI:10.1002/mds.870060203
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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3. |
Review and videotape recognition of idiopathic restless legs syndrome |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 105-110
Arthur S. Walters,
Wayne A. Hening,
Sudhansu Chokroverty,
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摘要:
AbstractThe motor phenomena associated with idiopathic restless legs syndrome (RLS) are infrequently seen in the physician's office because they are present only after prolonged sitting or lying and usually at night. These motor phenomena are captured on videotape in four unrelated patients with idiopathic RLS. The clinical features of idiopathic RLS are reviewed in detail, and therapeutic advances in its treatment are summarized.
ISSN:0885-3185
DOI:10.1002/mds.870060204
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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4. |
Oral levodopa dose‐response study in MPTP‐induced hemiparkinsonian monkeys: Assessment with a new rating scale for monkey parkinsonism |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 111-118
Roger Kurlan,
Michael H. Kim,
Don M. Gash,
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摘要:
AbstractQuantitative measures for the severity of MPTP‐induced parkinsonism and response to antiparkinsonian interventions in monkeys have been lacking. We carried out an oral levodopa dose‐response study in two rhesus monkeys whose left hemiparkinsonism was induced by intracarotid administration of MPTP. A newly developed clinical rating scale of monkey parkinsonism showed a consistent dose‐response relationship for levodopa over the dosage range of 50–3, 500 mg/day. Antiparkinsonian effects appeared at 200 mg/day and were optimal at 1,000–2,000 mg/day. Levodopa also reversed rotational behavior, improved movement times for both the impaired and opposite upper limb, and produced dyskinesias at high dosages. Thus, MPTP‐induced hemiparkinsonism in monkeys closely resembles the human disease condition, is associated with sensitive response measures, and should prove valuable for assessing novel antiparkinsonia
ISSN:0885-3185
DOI:10.1002/mds.870060205
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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5. |
Idiopathic cervical dystonia: Clinical characteristics |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 119-126
Jane Chan,
Mitchell F. Brin,
Stanley Fahn,
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摘要:
AbstractWe reviewed detailed clinical features of 266 patients with idiopathic cervical dystonia, commonly called spasmodic torticollis. Mean age at onset (41 years), female‐to‐male ratio (1.9:1), clustering of onset between ages 30 and 59 (70%), familial history of dystonia (12%), and remissions (9.8%) were similar to those found in previous studies. In contrast to the single prior large clinical study of this disorder, no predominance of right‐handers or significant thyroid disease was found. Pain, which occurred in 75% of patients and contributed to disability score (p75% of the time when sitting with the head unsupported (constant head deviation at rest). Of the 97% who had head turning, 81% also had head tilting in various combinations. The 23% with hand tremor had an older age at onset (mean, 46 vs. 41 years; p<0.05). An earlier age at onset (p<0.05) was seen in patients with a family history of dystonia (mean, 36 years), with trauma shortly preceding symptoms (mean, 36 years), with a change in the direction of head turning (mean, 30 years), and with remissions (mean, 33 years). Jerky movements or forced transient spasms of the head occurred in 62% of the patients, and these patients would be the ones for whom the designation “spasmodic torticollis” could logically apply. Therefore, because the cervical dystonia in 38% of patients is not spasmodic, we propose that the term “spasmodic torticollis” is not a completely appropriate designation for this condition. We suggest labeling the condition either idiopathic cervical dystonia or idiopathic dystonic torticollis, preferably the former for reasons explai
ISSN:0885-3185
DOI:10.1002/mds.870060206
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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6. |
Visuospatial cognition in Huntington's disease |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 127-132
Erich Mohr,
Pim Brouwers,
Jules J. Claus,
Ulrike M. Mann,
Paul Fedio,
Thomas N. Chase,
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摘要:
AbstractThe notion of specificity of visuospatial dysfunction in Huntington's disease (HD) was evaluated in a sample of afficted patients as a function of symptom duration, age at onset, and overall dementia severity. Factor analytic procedures indicated that overall visuospatial processing capacity (factor 1) as well as the ability for spatial manipulation (factor 3) was markedly affected in HD patients. In contrast, consistency of spatial judgment (factor 2) appeared to remain relatively intact in these patients. Age at onset seemed to have no relationship with any of these variables, whereas dementia severity demonstrated a significant relationship with overall visuospatial processing capacity. Most importantly, duration of symptoms was significantly associated with the declining ability to mentally perform spatial manipulations. The observation of circumscribed visuospatial impairment in HD patients may have important consequences for the further understanding of the neurobehavioral consequences of this disorder.
ISSN:0885-3185
DOI:10.1002/mds.870060207
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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7. |
Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 133-138
Jonathan M. Brotchie,
Ian J. Mitchell,
Michael A. Sambrook,
Alan R. Crossman,
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摘要:
AbstractRecent experimental data has made possible the description of the pathophysiological circuitry that mediates parkinsonism. This work has shown that dopamine‐denervated striatal cells discharge abnormally and that this ultimately causes cells in the medial segment of the globus pallidus to become abnormally overactive. The main driving force behind the overactive cells in the medial pallidal segment appears to be excess activity in the afferent pathway to it from the subthalamic nucleus. This pathway is known to use an excitatory amino acid (EAA) as its transmitter. It was therefore hypothesized that local blockade of EAA transmission in the medial segment of the globus pallidus should reverse parkinsonism. This hypothesis was tested in rat and primate models of parkinsonism by the direct injection of the EAA antagonist, kynurenic acid, into the medial segment of the globus pallidus. The results demonstrate that this procedure can reverse parkinsonism in a dose‐dependent manner, and suggest that manipulation of EAA transmission in the medial segment of the globus pallidus may have therapeutic potential for treating parkinson
ISSN:0885-3185
DOI:10.1002/mds.870060208
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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8. |
A case of postanoxic encephalopathy with cortical action and brainstem reticular reflex myoclonus |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 139-144
P. Brown,
P. D. Thompson,
J. C. Rothwell,
B. L. Day,
C. D. Marsden,
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摘要:
AbstractA patient with postanoxic encephalopathy, with both action‐ and stimulus‐sensitive reflex myoclonus, is described. The action myoclonus was multifocal and cortical in origin. In contrast, reflex myoclonus elicited by somaesthetic and auditory stimulation was generalised. The earliest reflex electromyograph activity was recorded in the sternocleidomastoid; myoclonic activity then spread up the brainstem and down the spinal cord, suggesting that this reflex myoclonus had its origin in the caudal brainstem. Stimulus sensitivity was greatest in the limbs. The bulbospinal motor pathways involved in the generalised reflex myoclonus were rapidly conducting, and this characteristic distinguishes this form of brainstem reflex myoclonus from that described in hyperekple
ISSN:0885-3185
DOI:10.1002/mds.870060209
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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9. |
Treatment of idiopathic spasmodic torticollis with botulinum toxin a: A double‐blind study on twenty‐three patients |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 145-150
I. T. Lorentz,
S. Shanthi Subramaniam,
C. Yiannikas,
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摘要:
AbstractIn a double‐blind, placebo‐controlled study, 23 patients suffering from intractable spasmodic torticollis (ST) were given successively either botulinum toxin A (BTA) or normal saline by intramuscular injections in the affected muscles. Evaluation was carried out by three blinded observers, using a clinical and video assessment of the severity of torticollis, employing a scoring system described by Tsui (1). Patients were also asked to subjectively comment on changes in the amount of pain and on changes in the activities of daily living (ADL). BTA was proven to be superior on all forms of assessment to placebo, and these results were statistically significant. Side effects mainly consisted of pain at the injection site. Tiredness occurred at equal frequency with BTA and placebo. No serious or systemic side effects were noted. Botulinum toxin is a safe, effective and relatively simple treatment for spasmodic torticol
ISSN:0885-3185
DOI:10.1002/mds.870060210
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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10. |
Gastrointestinal symptoms in Parkinson's disease |
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Movement Disorders,
Volume 6,
Issue 2,
1991,
Page 151-156
L. L. Edwards,
R. F. Pfeiffer,
E. M. M. Quigley,
Ruth Hofman,
Mary Balluff,
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摘要:
AbstractWe have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with Parkinson's disease (PD) and in a control group of 50. Seventy‐nine of those with PD were being treated with dopaminergic medications and 19 were untreated. Those symptoms occurring more frequently in PD patients than in controls included abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory dysfunction, symptoms did not correlate with treatment but instead correlated with disease severity. This suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease proces
ISSN:0885-3185
DOI:10.1002/mds.870060211
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1991
数据来源: WILEY
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