摘要:

AbstractA number of different designs of electrospray sources have been used to study the non‐covalent interaction between ribonuclease A and cytidylic acids. Signal differences were observed between the various types of source giving rise to very different spectra. However, in all cases, information was obtained relating to the putative comple

ISSN:0951-4198    

DOI:10.1002/rcm.1290080122

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY

摘要:

AbstractA novel hydrogen rearrangement reaction was found in benzyl ions that have a (benzyl) group (Z=O or N) at theirorthoposition. From deuterium labeling experiments, mass analyzed ion kinetic energy spectra with collisional activation, and examination of structure‐peak intensity correlation, a mechanism is proposed which involves a direct transfer of hydrogen (hydride) to the structurally remote but spatially close cationic center. The possibility of an alternative, less likely mechanism including an ion/neutral complex and/or a proton‐bridged complex has also been discus

ISSN:0951-4198    

DOI:10.1002/rcm.1290080123

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY

摘要:

AbstractA novel procedure based on electrospray tandem mass spectrometry (ESI‐MS/MS) has been used in the diagnosis of organic acidemias. The method is based on the determination of acylcarnitine profiles from blood spots collected on Guthrie cards. The acylcarnitines are extracted with methanol, derivatized to their butyl esters and analyzed by ESI‐MS/MS. Precursor‐ion scanning of the common fragment atm/z85 of the butyl esters yields highly diagnostic acylcarnitine profiles. Analysis time is one minute per sample and is fully automated. Examples are given of normal profiles, of profiles from two patients with fatty acid oxidation defects, and of a case of propionic acidemia. The technique is simple, rapid and specific, and shows potential for routine application in neonatal screening of organic acid

ISSN:0951-4198    

DOI:10.1002/rcm.1290080124

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY

摘要:

AbstractGlycylglycine (glygly) and 40 related acetamide derivatives were synthesized and investigated by fast‐atom bombardment mass spectrometry. The protonated molecules were mass selected and their collision‐induced dissociations were analyzed by tandem mass spectrometry. The data obtained allow a fragmentation pattern to be established for these glygly analogues and permit detailed structural information on the main fragment ions to be ascertai

ISSN:0951-4198    

DOI:10.1002/rcm.1290080125

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY

ISSN:0951-4198    

DOI:10.1002/rcm.1290080126

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY

ISSN:0951-4198    

DOI:10.1002/rcm.1290080127

出版商:Heyden&Son Limited    

年代:1994

数据来源: WILEY