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11. |
Dose‐and sex‐dependent alterations in mercury distribution in fetal mice following methylmercury exposure |
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Journal of Toxicology and Environmental Health,
Volume 19,
Issue 3,
1986,
Page 425-435
Minoru Inouye,
Yuji Kajiwara,
Kimiko Hirayama,
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摘要:
Methylmercuric chloride was orally given to inbred C57BLI6N mice on d 13 of pregnancy at doses of 2.5, 5, 10, and 20 mg/kg. Animals were sacrificed on each of d 14–18 of pregnancy, and mercury levels in the brain, liver, and kidney of both the fetus and dam were determined. The dose effect on the time course of mercury accumulation in the brain was observed both in the fetus and dam; after the higher doses administered, the brain mercury reached the highest concentration later than it did after the lower doses. In addition, the mercury concentration in the fetal brain was disproportionately higher after a dose of 20 mg/kg, which was toxic in the fetus since the weight of the brain was reduced. The concentration in the fetal brain was 1.6–4.9 times higher than in the maternal brain. The sex difference of fetuses in mercury levels was observed in the brain after a dose of 2.5 mg/kg, in which mercury concentration was higher in females than in males. This corresponded to the previously reported difference in adult mice and rats. However, the sex difference was not seen after doses of 5, 10, or 20 mg/kg.
ISSN:0098-4108
DOI:10.1080/15287398609530940
出版商:Taylor & Francis Group
年代:1986
数据来源: Taylor
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12. |
Lead concentration in deciduous teeth: Variation related to tooth type and analytical technique |
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Journal of Toxicology and Environmental Health,
Volume 19,
Issue 3,
1986,
Page 437-444
Philippe Grandjean,
Troels Lyngbye,
OleNørby Hansen,
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摘要:
A total of 245 newly shed deciduous incisors were obtained from 114 first‐grade children who each contributed more than one tooth. Lead concentrations averaged about fivefold higher in circumpulpal dentin than in the whole tooth, but the two parameters showed little correlation. A considerable intraindividual variation in lead levels was partly related to tooth type. In particular, whole upper central incisors contained more lead than did other incisors, but the reverse applied to circumpulpal dentin lead concentration. As whole‐tooth and circumpulpal lead concentrations may represent different compartments, tooth lead analyses must be interpreted accordingly. Lead levels in circumpulpal dentin would appear to be a meaningful indicator of long‐term lead retention in population studies of children.
ISSN:0098-4108
DOI:10.1080/15287398609530941
出版商:Taylor & Francis Group
年代:1986
数据来源: Taylor
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13. |
Book reviews |
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Journal of Toxicology and Environmental Health,
Volume 19,
Issue 3,
1986,
Page 445-447
KerryT. Givens,
N. B. Whittemore,
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摘要:
POISONOUS MUSHROOMS OF THE NORTHERN UNITED STATES AND CANADA. Edited byJoseph F. Ammirati, James A. Traquair, andPaul A. Horgen, University of Minnesota Press, Minneapolis, Minnesota, 1986, 396 pp, $75.00.
ISSN:0098-4108
DOI:10.1080/15287398609530942
出版商:Taylor & Francis Group
年代:1986
数据来源: Taylor
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14. |
Editorial board |
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Journal of Toxicology and Environmental Health,
Volume 19,
Issue 3,
1986,
Page -
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PDF (101KB)
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ISSN:0098-4108
DOI:10.1080/15287398609530929
出版商:Taylor & Francis Group
年代:1986
数据来源: Taylor
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