摘要:

An examination of the kidney and liver subsequent to the mobilization of aged cadmium deposits from them by the use of both dithiocarbamates and 1,2‐dimercapto‐1‐propranol (BAL) was carried out. No striking permanent effects due to cadmium mobilization were noted in the kidneys or livers for most of the chelating agents used. After the mobilization of part of the cadmium burden, the remaining cadmium gives evidence of undergoing a redistribution, leading to a renewed increase in both the kidney and liver levels of this element.

ISSN:0098-4108    

DOI:10.1080/15287398609530926

出版商:Taylor & Francis Group    

年代:1986

数据来源: Taylor

摘要:

Female B6C3F1mice were exposed to ammonium metavanadate (NH4VO3) by intra‐peritoneal injection every 3 d at 2.5, 5.0, or 10 mg V/kg for 3, 6, or 9 w and were then assayed for alterations in immunoresponsiveness. Resistance toEscherichia colien‐dotoxin lethality increased in a dose‐dependent manner up to 6 w of exposure, while resistance to viable gram‐positiveListerialethality was depressed in a dose‐dependent manner. Comparison of LD20 values indicated a 250‐fold decrease in resistance toListeriaat the lowest vanadium exposure and a 40% increase in resistance to endo‐toxin after the highest vanadium exposure. Peritoneal macrophage phagocytic capacities were decreased in a dose‐dependent manner, but viabilities remained unaffected. Rosetting capacity of splenic lymphocytes was increased following vanadium exposure. Liver and splenic enlargement was observed, and examination of splenic tissue indicated enhanced formation of megakaryocytes and red blood cell precursors. Subchronic exposure to vanadium may thus disrupt the normal function of the immune system.

ISSN:0098-4108    

DOI:10.1080/15287398609530927

出版商:Taylor & Francis Group    

年代:1986

数据来源: Taylor

摘要:

CHEMICAL INDUCTION OF CANCER‐STRUCTURAL BASES AND BIOLOGICAL MECHANISMS, VOL. IIIB, ALIPHATIC AND POLYHALOGENATED CARCINOGENS. Edited byT.‐T. Woo, D. Y. Lai, J. C. Arcos, and M. F. Argus, Academic Press, New York, 1985, 598 pp., $138.00.

ISSN:0098-4108    

DOI:10.1080/15287398609530928

出版商:Taylor & Francis Group    

年代:1986

数据来源: Taylor

ISSN:0098-4108    

DOI:10.1080/15287398609530915

出版商:Taylor & Francis Group    

年代:1986

数据来源: Taylor