摘要:

Lead acetate (PbAc) was tested for its effects on the production and release of erythrocytes‐that is, erythropoiesis‐in ICR mice. Dose‐survival data indicate that a dosage of 20 mg PbAc/100 g body weight represents the maximum tolerable treatment level. No differences in survival at the various levels of the salt were observed with regard to sex or age. For erythropoietic effects of PbAc, mice were injected on day 0, and radioiron (59Fe) incorporation percentages were determined at daily intervals through day 8 for both erythrocytes and splenic tissue. Control mice received isotonic saline as the injectate. On day 3, the percentages obtained from Pb Ac‐treated mice showed a decline, reaching their minimum value by day 4. Recovery from erythropoietic suppression appeared to be complete by day 6 or 7; no positive overshoots in59Fe percentages were found following recovery. These trends were typical for both peripheral red blood cells and spleen. Testosterone was administered to mice receiving saline or PbAc on two consecutive days (days —1 and 0). Radioiron uptake percentages for females receiving testosterone and saline showed an abrupt increase on day 4. No accelerative effect due to testosterone was found in recipient moles. For females treated with testosterone and PbAc, the radioiron percentages for erythrocytes and spleen paralleled those for females receiving saline only. Male mice treated with both androgen and PbAc demonstrated59Fe percentages typical of males treated with PbAc alone.

ISSN:0098-4108    

DOI:10.1080/15287397709529590

出版商:Taylor & Francis Group    

年代:1977

数据来源: Taylor

摘要:

BALB/c StCrlfC3Hf/Nctr, CS7BL/6J, C57BL/6 X BALB/c F1hybrid (B6CF1), and monohybrid‐cross offspring from the breeding of B6CF1mice were examined with respect to uterine, vaginal, and thymus responses to diethylstilbestrol (DES). About 400 mice of each genetic population were used. Weanling mice were fed DES at dietary concentrations of 2.5 to 1,000 ppb (μg/kg feed) for 6 days and were killed by cervical dislocation about 20 hr after removal of the feed. C57BL/6, B6CF1, and the monohybrid‐cross offspring did not differ in the uterine‐weight response to DES, but the slope of the dose‐response line was shallower for the BALB/c than for the other strains. Dietary DES concentrations of 250 ppb or more inhibited the uterotrophic response in all populations. Vaginal cornification occurred at lower concentrations of DES in the C57BL/6 strain than in the B6CF1animals. BALB/c and monohybrid‐cross offspring were indistinguishable from each other in their vaginal response to DES and were less sensitive to DES than the other mouse populations. The use of ethanol or corn oil as the solvent for mixing DES into the diet had no apparent effect on the uterine weight or vaginal response in any of the mice. DES depressed thymus weight in a dose‐related fashion at dietary concentrations of 100 ppb and above in all genetic populations.

ISSN:0098-4108    

DOI:10.1080/15287397709529591

出版商:Taylor & Francis Group    

年代:1977

数据来源: Taylor

摘要:

The intestinal absorption, distribution, and excretion of the major component of Firemaster BP‐6, 2,4,5,2’,4’,5'‐hexabromobiphenyl, has been studied in the male rat. This polybrominated biphenyl was readily absorbed from the intestine, initially distributed throughout the body, and eventually stored primarily in the adipose tissue, was not subject to appreciable metabolism, and was excreted almost exclusively in the feces and at a very stow rate. Approximately 90% of an oral dose was absorbed from the intestine, and extrapolation of the rate of excretion to infinity indicates that less than 10% of the total dose would ever be excreted.

ISSN:0098-4108    

DOI:10.1080/15287397709529592

出版商:Taylor & Francis Group    

年代:1977

数据来源: Taylor

ISSN:0098-4108    

DOI:10.1080/15287397709529593

出版商:Taylor & Francis Group    

年代:1977

数据来源: Taylor

ISSN:0098-4108    

DOI:10.1080/15287397709529569

出版商:Taylor & Francis Group    

年代:1977

数据来源: Taylor