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11. |
Persistent Elevation of Plasma Insulin Levels Is Associated With Increased Cardiovascular Risk in Children and Young AdultsThe Bogalusa Heart Study |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 54-59
Weihang PhD Bao,
Sathanur R. PhD Srinivasan,
Gerald S. MD Berenson,
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摘要:
BackgroundHyperinsulinemia has been considered to be a potent cardiovascular risk factor. The present investigation examines persistently elevated fasting insulin levels from childhood to young adulthood and its influence on cardiovascular risk factors.Methods and ResultsA longitudinal cohort was constructed from two cross-sectional surveys in a community-based population over an 8-year period: 1606 individuals (39% were black) aged 5 to 23 years participated in the first survey. Stability in rankings (persistence) of insulin levels was shown by the presence of significant correlations between year 1 and year 8 values (r = .23 to .36, P < .0001), with a greater magnitude in older subjects. Compared with subjects with levels of insulin consistently in the lowest quartile, those with levels always in the highest quartile showed higher (P < .001) levels of body mass index (+9 kg/m2), triglycerides (+58 mg/dL), LDL cholesterol (+11 mg/dL), VLDL cholesterol (+8 mg/dL), glucose (+9 mg/dL), systolic blood pressure (+7 mm Hg), and diastolic blood pressure (+3 mm Hg); lower (P < .001) levels of HDL cholesterol (-4 mg/dL); and higher (P < .05) prevalence of parental history of diabetes (3.3-fold) and hypertension (1.2-fold). There were 739 young adults aged 20 to 31 years at follow-up. As adults, individuals with consistently elevated insulin versus those with consistently decreased insulin had increased (P < .05) prevalence of obesity (36-fold), hypertension (2.5-fold), and dyslipidemia (3-fold), which was attributed to both baseline insulin and change of insulin from baseline to follow-up. In addition, clustering of these risk factors was stronger (P < .05) in adults with persistent insulin elevation.ConclusionsElevated insulin levels persist from childhood through young adulthood, resulting in a clinically relevant adverse cardiovascular risk profile in young adults. (Circulation. 1996;93:54-59.)Key Wordsinsulin, follow-up studies, risk factors.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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12. |
Blood Pressure in Young Blacks and WhitesRelevance of Obesity and Lifestyle Factors in Determining DifferencesThe CARDIA Study |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 60-66
Kiang PhD Liu,
Karen J. MS Ruth,
John M. MD Flack,
Rhonda DrPH Jones-Webb,
Gregory MD Burke,
Peter J. MD Savage,
Stephen B. MD Hulley,
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摘要:
BackgroundMiddle-aged black men and women have higher blood pressure, on average, than whites. However, this pattern is inconsistent in children and adolescents. This study explores how differences in lifestyle factors in young adulthood may influence blood pressure patterns in the two races.Methods and ResultsThe Coronary Artery Risk Development in Young Adults (CARDIA) study is an ongoing collaborative investigation of lifestyle and the evolution of cardiovascular disease risk factors in a random sample of young adults ages 18 to 30 years at baseline (1985 to 1986). Data from four examinations over 7 years were analyzed with the use of a method that simultaneously examined cross-sectional and longitudinal relationships of lifestyle factors and blood pressure. This study included 1154 black women, 853 black men, 1126 white women, and 1013 white men. Blacks had higher systolic blood pressure and diastolic blood pressure than whites at every examination. Racial differences were much greater in women than in men and increased over time. Within each sex-race group, average diastolic blood pressure over four examinations was positively associated with baseline age, body mass index, and alcohol intake and negatively associated with physical activity, cigarette use, and intake of potassium and protein. Longitudinal change in diastolic blood pressure was positively associated with changes in body mass index and alcohol intake. After adjustment for obesity and other lifestyle factors, black-white diastolic blood pressure differences were reduced substantially: 21% to 75% for men and 49% to 129% for women. Results for systolic blood pressure were similar.ConclusionsDifferences in obesity and other lifestyle factors in young adults largely explain the higher baseline blood pressure and greater increase over time of blacks relative to whites. (Circulation. 1996;93:60-66.)Key Wordsblood pressure, lifestyle, obesity, race.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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13. |
From the American Heart Association |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 65-66
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ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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14. |
Energetically Optimal Left Ventricular Pressure for the Failing Human Heart |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 67-73
Hidetsugu MD Asanoi,
Tomoki MD Kameyama,
Shinji MD Ishizaka,
Takashi MD Nozawa,
Hiroshi MD Inoue,
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摘要:
BackgroundAn energy-starved failing heart would benefit from more effective transfer of the mechanical energy of ventricular contraction to blood propulsion. However, the energetically optimal loading conditions for the failing heart are difficult to establish. In the present study, we analyzed the optimal left ventricular pressure to achieve maximal mechanical efficiency of the failing heart in humans.Methods and ResultsWe determined the relation between left ventricular pressure-volume area and myocardial oxygen consumption per beat (VO2), stroke work, and mechanical efficiency (stroke work/VO sub 2) in 13 patients with different contractile states. We also calculated the optimal end-systolic pressure that would theoretically maximize mechanical efficiency for a given end-diastolic volume and contractility. Left ventricular pressure-volume loops were constructed by plotting the instantaneous left ventricular pressure against the left ventricular volume at baseline and during pressure loading. The contractile properties of the ventricle were defined by the slope of the end-systolic pressure-volume relation. In patients with less compromised ventricular function, the operating end-systolic pressure was close to the optimal pressure, achieving nearly maximal mechanical efficiency. As the heart deteriorated, however, the optimal end-systolic pressure became significantly lower than normal, whereas the actual pressure remained within the normal range. This discrepancy resulted in worsening of ventriculoarterial coupling and decreased mechanical efficiency compared with theoretically maximal efficiency.ConclusionsHomeostatic mechanisms to maintain arterial blood pressure within the normal range cause the failing heart to deviate from energetically optimal conditions. (Circulation. 1996;93:67-73.)Key Wordsblood pressure, contractility, heart failure, mechanics, autonomic nervous system.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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15. |
Prospective 12-Year Follow-up Study of Clinical and Hemodynamic Sequelae After Deep Vein Thrombosis in Low-Risk Patients (Zurich Study) |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 74-79
Ulrich K. MD Franzeck,
Ilse RVT Schalch,
Kurt A. MD Jager,
Ernst MD Schneider,
Jorg PhD Grimm,
Alfred MD Bollinger,
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摘要:
BackgroundNo prospective study of the long-term sequelae of more than 10 years after acute deep vein thrombosis exists so far. Therefore, 58 low-risk patients with DVT were included in a prospective study to evaluate the natural history of postthrombotic syndrome.Methods and ResultsClinical and hemodynamic examinations were performed at the time of admission; after 3, 6, and 12 months; after the 2nd, 3rd, 4th, 5th years; and finally after the 12th year. All patients received heparin initially and oral anticoagulants subsequently. After 12 years, 64% of the patients exhibited normal findings. Mild skin changes were found in 28%, marked trophic changes in 5%, and only one venous ulcer occurred. Regular use of compression stockings was reported by 54% of the patients with multilevel thrombosis. Although mean maximum venous outflow was significantly reduced from the acute event to 12 years later (P < .003) compared with the contralateral leg, a significant (P < .05) improvement was observed 6 months later. Recanalization of calf vein thrombosis was detected by Doppler sonography after 3 months. Sixty-four percent of the multilevel thromboses were recanalized completely or in part after 1 year; in 69%, valvular incompetence was found.ConclusionsIn contrast to earlier reports, this prospective study up to 12 years after deep vein thrombosis demonstrates a low incidence of postthrombotic syndrome by administration of oral anticoagulants and regular compression therapy. However, the adverse clinical event rate (mortality 14%) and a recurrence rate of 24% show that the prognosis after deep vein thrombosis does not appear favorable even in low-risk patients. (Circulation. 1996;93:74-79.)Key Wordsthrombosis, veins.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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16. |
Low-Molecular-Weight Heparinoid Orgaran Is More Effective Than Aspirin in the Prevention of Venous Thromboembolism After Surgery for Hip Fracture |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 80-84
M. DSc Gent,
J. MD Hirsh,
J.S. MD Ginsberg,
P.J. MD Powers,
M.N. MD Levine,
W.H. MD Geerts,
R.M. MD Jay,
J. MD Leclerc,
FRCP(C) Neemeh J.A. MD,
A.G.G. MBChB Turpie,
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摘要:
BackgroundThe study objective was to determine the relative efficacy and safety of a low-molecular-weight heparinoid (Orgaran) compared with aspirin for the prevention of postoperative venous thromboembolism in patients undergoing surgery for fractured hips. A double-blind, randomized, controlled trial was used to study 251 consecutive eligible and consenting patients undergoing surgery for hip fracture in seven participating hospitals.Methods and ResultsPatients received either fixed-dose Orgaran by subcutaneous injection every 12 hours in a dose of 750 anti-Factor Xa units or aspirin 100 mg orally twice daily; both regimens were started 12 to 24 hours after surgery and continued for 14 days or until discharge, if sooner. All patients had postoperative125I-fibrinogen leg scanning and impedance plethysmography. If the results of one or both tests were positive, then venography was performed. Otherwise, venography was done at day 14, or sooner if the patient was ready for discharge. Pulmonary embolism in symptomatic patients was diagnosed on the basis of a high probability perfusion/ventilation lung scan, a positive angiogram, or a clinically significant embolism detected at autopsy. Evaluable venograms were obtained in 90 of the 125 patients randomly assigned to receive Orgaran and in 87 of the 126 patients assigned to receive aspirin. Venous thromboembolism was detected in 25 (27.8%) patients in the Orgaran group and in 39 (44.3%) patients in the aspirin group. Thus, there was a relative risk reduction of 37% with Orgaran (P = .028; 95% confidence interval, 3.7% to 59.7%). Six (6.8%) of 88 patients in the Orgaran group and 12 (14.3%) of 84 patients in the aspirin group developed proximal deep vein thrombosis or pulmonary embolism, a relative risk reduction of 52% with Orgaran (P = .137; 95% confidence interval, -30.7% to 84.6%). Hemorrhagic complications occurred in 2 (1.6%) patients given Orgaran and 8 (6.4%) patients given aspirin (P = .10). There was one major bleed in the Orgaran group compared with four in the aspirin group.ConclusionsThis study demonstrates that Orgaran is significantly more efficacious than aspirin in preventing postoperative venous thromboembolism in patients undergoing surgery for fractured hips, with no evidence of any increase in hemorrhagic complications. (Circulation. 1996;93:80-84.)Key Wordsaspirin, thrombosis, surgery, heparin.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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17. |
L-Arginine Induces Nitric Oxide--Dependent Vasodilation in Patients With Critical Limb IschemiaA Randomized, Controlled Study |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 85-90
Stefanie M. MD Bode-Boger,
Rainer H. MD Boger,
Heiko MD Alfke,
Doris MD Heinzel,
Dimitrios PhD Tsikas,
Andreas MD Creutzig,
Klaus MD Alexander,
Jurgen C. MD Frolich,
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摘要:
BackgroundL-Arginine is the precursor of endogenous nitric oxide (NO), which is a potent vasodilator acting via the intracellular second-messenger cGMP. In healthy humans, L-arginine induces peripheral vasodilation and inhibits platelet aggregation due to an increased NO production. Prostaglandin E1(PGE1) induces peripheral vasodilation via stimulating prostacyclin receptors.Methods and ResultsWe investigated the effects of one intravenous infusion of L-arginine (30 g, 60 minutes) or PGE1(40 micro gram, 60 minutes) versus those of placebo (150 mL 0.9% saline, 60 minutes) on blood pressure, peripheral hemodynamics, and urinary NO3sup - and cGMP excretion rates in patients with critical limb ischemia (peripheral arterial occlusive disease stages Fontaine III or IV). Blood flow in the femoral artery was significantly increased by L-arginine (+42.3 plus/minus 7.9%, P < .05) and by PGE1(+31.0 plus/minus 10.2%, P < .05) but not by placebo (+4.3 plus/minus 13.0%, P = NS). Urinary NO3sup -1 excretion increased by 131.8 plus/minus 39.5% after L-arginine (P < .05) but only by 32.3 plus/minus 17.2% after PGE1(P = NS). Urinary cGMP excretion increased by 198.7 plus/minus 84.9% after L-arginine (P < .05) and by 94.2 plus/minus 58.8% after PGE1(P = NS). Both urinary index metabolites were unchanged by placebo.ConclusionsWe conclude that intravenous L-arginine induces NO-dependent peripheral vasodilation in patients with critical limb ischemia. These effects are paralleled by increased urinary NO3sup - and cGMP excretion, indicating an enhanced systemic NO production. Increased urinary NO3sup - excretion may be a sum effect of NO synthase substrate provision (L-arginine) and increased shear stress (PGE sub 1 and L-arginine). (Circulation. 1996;93:85-90.)Key WordsL-arginine, prostaglandins, peripheral vascular disease, nitric oxide.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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18. |
Undetected Ventricular Fibrillation in Transvenous Implantable Cardioverter-DefibrillatorsProspective Comparison of Different Lead System-Device Combinations |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 91-98
Andrea MD Natale,
Jasbir MD Sra,
Kathi RN Axtell,
Masood MD Akhtar,
Keith MD Newby,
Virginia RN Kent,
Mary J. MD Geiger,
M. Joan RT Brandon,
Margaret M. RN Kearney,
Antonio MD Pacifico,
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摘要:
BackgroundThe purpose of this study was to prospectively analyze redetection problems after unsuccessful shock with different lead systems and devices.Methods and Results6-mm electrode separation. After antitachycardia pacing in 1 patient and a 2-J shock in 1 patient, ventricular tachycardia turned into VF, which was undetected. Both patients used the Endotak 60 series-Cadence combination. None of the patients showing VF undersensing had sudden death at follow-up. Only 3 of the 12 patients with sensing malfunction were on antiarrhythmia drugs at the time of testing. Analysis of endocardial electrograms showed that failure to redetect VF is not associated with a uniform reduction but with a rapid and repetitive change of electrogram amplitude.ConclusionsStandard bipolar sensing redetects VF more effectively than integrated bipolar sensing. Endocardial electrogram analysis provides insights into the understanding of the mechanism of undersensing, and certain lead-device combinations result in a higher occurrence of VF undersensing. The clinical relevance of this phenomenon remains unknown. (Circulation. 1996;93:91-98.)Key Wordsdefibrillation, fibrillation, death, sudden.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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19. |
Induction of DNA Synthesis by a Single Transient Mechanical Stimulus of Human Vascular Smooth Muscle CellsRole of Fibroblast Growth Factor-2 |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 99-105
George C. MS Cheng,
Peter MD Libby,
Alan J. PhD Grodzinsky,
Richard T. MD Lee,
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摘要:
BackgroundAlthough mechanical vascular injury leads to smooth muscle cell proliferation that contributes to restenosis after balloon angioplasty, the role of the single transient mechanical stimulation of smooth muscle cells in this process is unknown.Methods and ResultsTo test the hypothesis that a single transient mechanical stimulus can increase DNA synthesis, human vascular smooth muscle cells cultured in a three-dimensional collagen gel system were subjected to transient compression. Transient compression (5-minute duration) of smooth muscle cell-collagen gel cultures in defined serum-free conditions led to delayed increases in [sup 3H]thymidine incorporation. At 12 to 24 hours after compression, there was a 3.3 plus/minus 0.5-fold (P < .001 versus control) and 3.0 plus/minus 0.6-fold (P < .002 versus control) increase for 60% and 80% strain, respectively; at 24 to 36 hours after compression, there was a 1.8 plus/minus 0.5-fold (P < .05 versus control) and 4.3 plus/minus 0.8-fold (P < .001 versus control) increase. Also, serum-free media conditioned by transiently compressed gel cultures induced DNA synthesis in control, unstimulated smooth muscle cell cultures, suggesting the release of growth factors by transient compression. Although neutralizing antibodies against platelet-derived growth factor did not affect the mechanical induction of DNA synthesis, a neutralizing monoclonal antibody against fibroblast growth factor-2 (FGF-2) decreased this induction by 89% and completely blocked the increase in DNA synthesis caused by media conditioned by transiently compressed gels. Media conditioned by transient compression contained elevated levels of FGF-2 (17 plus/minus 5 versus 2 plus/minus 2 pg/mL for control, P < .005) with no increase in lactate dehydrogenase activity, suggesting release of FGF-2 with sublethal cellular injury.ConclusionsA single transient mechanical stimulus increases DNA synthesis in human vascular smooth muscle cells, in part by autocrine or paracrine FGF-2 release. (Circulation. 1996;93:99-105.)Key Wordsarteriosclerosis, stress, growth substances.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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20. |
Elaboration of Type-1 Plasminogen Activator Inhibitor From AdipocytesA Potential Pathogenetic Link Between Obesity and Cardiovascular Disease |
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Circulation,
Volume 93,
Issue 1,
1996,
Page 106-110
Craig H. MD Lundgren,
Steven L. MD Brown,
Thomas K. MD Nordt,
Burton E. MD Sobel,
Satoshi MD Fujii,
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摘要:
BackgroundObesity is known to predispose to attenuated fibrinolysis attributable to increased concentrations in plasma of type-1 plasminogen activator inhibitor (PAI-1), the primary physiological inhibitor of endogenous fibrinolysis. PAI-1 is present in neointimal vascular smooth muscle cells and lipid-laden macrophages.Methods and ResultsThe present study was designed to determine whether PAI-1 expression occurs in adipose tissue as well, thereby potentially contributing to increased cardiovascular risk associated with obesity. 3T3-L1 preadipocytes were differentiated into adipocytes by exposing them to isobutylxanthine (0.5 mmol/L) and dexamethasone (0.25 micro mol/L) over 7 days and incubated for 24 hours with transforming growth factor-beta (TGF-beta), known to augment PAI-1 synthesis in several cell types and to be released from platelets when they are activated. TGF-beta increased PAI-1 activity in the conditioned media of the 3T3-L1-derived cells in a concentration-dependent fashion without significantly affecting cell proliferation. Western blotting and immunoprecipitation of35S-labeled PAI-1 showed that the increased PAI-1 activity paralleled increased PAI-1 protein. Northern blotting showed that increased PAI-1 mRNA preceded increased accumulation of PAI-1 activity and protein in the conditioned media. Furthermore, TGF-beta (10 ng/g body wt) administered in vivo increased PAI-1 activity in mouse plasma and PAI-1 mRNA expression in mouse adipose tissue.ConclusionsIncreased plasma PAI-1 activity in obese human subjects may result from PAI-1 release from an increased mass of adipose tissue, particularly in association with thrombosis and elaboration of TGF-beta from platelet alpha-granules into the circulation. The increased PAI-1 may exacerbate vascular disease by shifting the balance between thrombosis and thrombolysis toward thrombosis and consequently exposing luminal surfaces of vessels to mitogens associated with microthrombi over protracted intervals. (Circulation. 1996;93:106-110.)Key Wordsplasminogen activator inhibitor, adipocyte, obesity, risks.
ISSN:0009-7322
出版商:OVID
年代:1996
数据来源: OVID
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