ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

The therapy for thromboangiitis obliterans advised by George E. Brown and his collaborators in 1928 is taken as a starting point for a discussion of modern conservative measures now properly used in the treatment of peripheral vascular disease of the obstructive type.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

The role of the liver in the excretion and destruction of digitoxin was studied in the rat, rabbit, dog and man (in part). It was found that no more than 10 per cent of a given dose of digitoxin is excreted in the bile of the animals tested and none could be detected in the bile of two human subjects. Evidence was obtained which suggested that in the rat and rabbit, the liver was able to destroy a large amount of injected digitoxin.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

The functional changes in respiration, circulation, blood composition and blood temperature were investigated in anesthetized dogs that were subjected to the inhalation of steam. The pathogenesis of the accompanying pulmonary congestion and edema was analyzed by measurements of: (a) pulmonary blood flow, (b) pressures in pulmonary artery and vein, (c) pulmonary blood (P32) volume, (d) electrical (AC) resistance of the lungs, and (e) edema fluid of the excised lung. The peculiarities of the pulmonary circulation that were demonstrated by bleeding and blood infusion explain the difficulties of correcting the congestion that regularly preceded thermal edema.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

An attempt has been made to elicit atherosclerosis in rats by duplicating as far as possible those conditions which in other animals are atherogenic. By making the rats hypothyroid and feeding cholic acid and cholesterol, severe hypercholesterolemia and abnormal beta-lipoproteins appeared along with heavy lipid infiltration of the kidneys, liver, heart and aorta. Aortic and coronary atherosclerosis might have been expected in rats exposed to so much atherogenic material in the blood, but it was not found. Despite lipid infiltration in the intima of the vessels, no appreciable tissue reaction to it occurred; we believe the lack of tissue response is one of the chief causes for the failure of atherosclerosis to develop. Thus tissue response and receptivity to lipid deposition seem to be important mechanisms in atherogenesis.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Hemodynamic studies were made in 42 patients with rheumatic heart disease with various valvular lesions and in different stages of cardiac function. These studies include observations not only at rest, but also during exercise, following the acute administration of Digoxin, and after recovery from failure. The relationship between symptomatology and hemodynamic findings were considered and the importance of differentiating between mechanical block and left ventricular myocardial failure as causes for pulmonary artery hypertension is stressed.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Although abundant evidence of concomitant cardiovascular disease is scattered throughout the literature on osteitis deformans, appreciation of the etiologic relationship between the two diseases has been lacking. This paper shows that cardiovascular disease accompanying extensive osteitis deformans may result from: (1) excessive demand on the heart from increased vascularity of affected bones; (2) the influence of concomitant arteriosclerosis apparently exceeding the normal for the age concerned; (3) characteristic thoracic spine deformities which compromise cardiorespiratory function, and (4) hypertension. Fifty-four cases are presented. The incidence of cardiovascular disease exceeds that in the general population of the same age and corresponds with the extent of skeletal involvement.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

In cases of aortic coarctation determinations of the wall-to-lumen ratio were made for the arterioles of the thyroid, pancreas, kidney and periadrenal tissue and compared with those for arterioles from the same organs in control cases. As in primary hypertension, there was, on the average, an increase in the wall-to-lumen ratio in each of the regions studied in the cases of coarctation as compared with the same tissues of the control group. This means that for arterioles of the same wall size the lumen was narrower in the cases of coarctation than in the control cases.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

The recent tendency to accept the syndromes of coronary artery disease as an indication of the presence or relative absence of coronary atherosclerosis in the living patient is open to serious objection. The production of these syndromes would appear to depend, not so much on the degree of coronary atherosclerosis, as on the presence of extraneous factors which precipitate occlusion. Of these factors, hemorrhage into atherosclerotic plaques is of major importance. The etiology of this lesion, and the manner in which it precipitates occlusion, are reviewed.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

An oximeter has been used to measure the arterial oxygen saturation of patients with a variety of congenital heart anomalies. The effects of exercise and oxygen administration have been of value in ascertaining the presence of a venous-arterial shunt. The rise in arterial oxygen saturation during a vigorously performed voluntary hyperventilation appears to offer a means of gaging the extent to which the pulmonary circulation may be increased; a less than normal increase has only been found in the presence of pulmonic stenosis or in some instances of pulmonary hypertension and a relatively fixed pulmonary resistance. The results of hyperventilation are sufficiently distinctive to be of diagnostic value in cases of Fallot's tetralogy, Eisenmenger's complex, isolated pulmonic stenosis, pulmonic stenosis with intact ventricular septum and patent foramen ovale, and Ebstein's anomaly of the tricuspid valve with patent foramen ovale.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID