ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Forty-four (32.8 per cent) of 134 patients[see figure in the PDF file]treated continuously with guanethidine for a period of at least 12 months developed recognizable fluid retention.Previous edema may be a predisposing factor and fluid retention occurred more commonly in women. Neither of these factors offers a complete explanation of this side effect.No evidence has been found to suggest that fluid retention occurs preferentially in patients with renal or cardiac insufficiency. The findings are compatible with a universal fluidretaining influence of guanethidine presenting as a graded phenomenon.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Total exchangeable sodium and blood volume increased during the first year's treatment of seven hypertensive patients with guanethidine. Creatinine clearance values fell over the same period.A similar change was seen in two patients receiving reserpine. It is suggested that the hemodynamic changes produced by hypotensive drugs are insufficient completely to explain the observations. A direct effect of guanethidine on sodium reabsorption in the kidney may also be involved.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

A study of 537 patients referred to the Cardiac Work Evaluation Unit of Boston during the 5-year period from 1955 to 1960 has been undertaken. The present report concerns the 375 individuals with coronary or hypertensive heart disease evaluated during the period of study.Of the total number, 76 were considered unemployable and 299 (80 per cent) employable. Of the employable, 64 (21 per cent) are known to have died subsequently. Of those for whom some follow-up was obtained, 82 per cent returned to work or continued working after initial evaluation. When last known, 64 per cent of those still alive were still working. The mean duration of follow-up for this series was 4.5 years.Consideration of the factors that may influence the subsequent employment experience indicated that successful employment was significantly more frequent for subjects below the age of 50, with favorable current cardiac classification (IIB or better), with apparently good motivation, or after a period of unemployment less than 1 year, than for patients inwhom any of these factors was unfavorable. Certain specific medical factors, such as heart size, history of previous myocardial infarctions, and blood pressure, had a less constant relation to subsequent employment, though they did have some relation to the medical prognosis.There was no indication in the present study that employment influenced the mortality statistics.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Fifteen cases of severe mitral regurgitation secondary to ruptured chordae tendineae have been reviewed, eight of whom underwent open-heart surgery to correct their lesions. Three patients are living at this time with two being markedly improved. Cardiac catheterization was performed in six prior to surgery.Progressive deterioration within the year following the onset of difficulty or sudden worsening of previous cardiac symptoms characterized the usual clinical course. The apical systolic murmur, always loud, was conspicuously harsh and radiated to the base of the heart, simulating aortic stenosis when the mural cusp was ruptured. Although strongly suggesting the diagnosis, the sudden onset of an apical systolic murmur could be documented in only three instances. The presence of a small left atrium radiographically with tall left atrial “v” waves and marked reflux of contrast material into a paradoxically pulsating left atrium also pointed to the correct diagnosis.Various technics of surgical repair and problems influencing survival of patients in the present series are discussed.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Cardiac output and intravascular pressure were measured before and after large doses of glucocorticosteroids administered intravenously to nine normal subjects and nine patients in shock. Glucocorticoids caused a sustained increase in cardiac output and a decrease in calculated peripheral resistance. No changes in mean arterial and venous pressures were observed. Possible mechanisms underlying these pharmacologic effects and their implications for the treatment of shock are discussed.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

In 535 male hypertensive patients the correlation coefficient between the corrected transverse diameter of the heart and the systolic pressure was +0.301. With diastolic pressure the correlation coefficient was +0.209. Both coefficients were significant (p<0.001), but the association between the variables was quite small in both correlations. The correlation between the corrected transverse diameter and the systolic pressure was significantly better than with the diastolic pressure, (p<0.001). The correlation between the corrected transverse diameter and the systolic pressure was independent of age.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID