ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

The use of heparin and dicumarol has provided important information regarding the effectiveness and the difficulties of anticoagulant therapy. Neither, however, is an ideal anticoagulant; therefore a search for new substances with advantages over them must be continued. Tromexan, which is administered orally, appears to have the advantages of more rapid utilization and more rapid cessation of action than dicumarol, although the mode of action is similar in that it produces a hypoprothrombinemia. It does require accurate prothrombin tests for satisfactory clinical use. It appears to be less prone to producing hemorrhagic complications. Animal and clinical experiences with Tromexan are herewith presented.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

The common use of dicumarinyl derivatives for the treatment of thromboembolic diseases justifies further clinical evaluation of dicumarol and 4,4'-dihydroxydicumarinyl ethyl acetate [Pelentan, Tromexan, 3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester.]The need for a more thorough understanding of the pharmacodynamic action of dicumarinyl anticoagulants has prompted a study of their gross metabolism in animals, using C14-labeled materials.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

The application of a spatial vector method of interpretation to the S-T and T deflections in the conventional electrocardiogram is described, and the vector abnormalities responsible for the more commonly encountered deformities are discussed. In addition, the isolated T-negativity syndrome is described, a rare type of precordial T-wave inversion which may be encountered in normal subjects and is often indistinguishable from the ST-T deformity of recent myocardial infarction. The spatial vector method of interpretation is found to provide a simple yet rational basis for the interpretation of these often bizarre wave forms.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Simultaneous catheterization of the left and right ventricles was performed in a case of right bundle branch block. It was thought that in right bundle branch block the polarity of the initial deflection of the potentials obtained in the left ventricular cavity could be studied without interference of those contributed by the right ventricular cavity. A description of the technic employed is given. The results confirm those obtained in dogs. There is initial negativity of the potentials obtained within the left ventricular cavity.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

A search of the literature has revealed the reports of only 14 cases of situs inversus of the abdominal viscera with levocardia. Eight additional cases are presented in this paper. Angiocardiography and/or heart catheterization was carried out on 6 of these and a Blalock-Taussig operation was performed subsequently on each patient. The autopsy findings in 2 instances, together with the results of special investigations in surviving patients, indicate that the malformations are of a bizarre nature. Anomalies of the venous return to the heart are particularly common and variable degrees of transposition of the great vessels are postulated.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Four patients with acute rheumatic carditis of moderate to severe degree were treated with cortisone. After a latent period of 5 to 15 days, there was fairly rapid subsidence in temperature, erytlhrocyte sedimentation rate and some other signs of inflammation. After cessation of the course of cortisone therapy, there was evidence of recrudescence of rheumatic activity in all four patients. In three of these the therapy was resumed, with quite unusually rapid decline in the fever and sedimentation rate. The cardiologic signs showed no improvement throughout the entire period of observation.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Observations of cardiac work were made in normal persons and in patients with coronary heart disease after ascending an ordinary staircase at various rates of speed. Cardiac output was calculated from records obtained with the low frequency, critically-damped ballistocardiograph. The results were compared, for statistical significance, with those noted following descent and after walking for an equivalent distance on the level. It appears that the compensated coronary patient can mount a flight of stairs leisurely without imposing a greatly increased burden of work on the heart. The optimal rate of ascent usually is the one chosen by the individual.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Two cases of mitral insufficiency are reported. In 1 case the lesion was produced by rupture of the chordae tendineae of the posterior leaflet of the mitral valve. In the other case it was produced by fibrous adhesion of the posterior leaflet of the mitral valve to the underlying left ventricular wall, which occurred during healing of subacute bacterial endocarditis. Changes occurred in the pulmonary vascular bed which are essentially identical with those found in mitral stenosis.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID

摘要:

Following a review of experimental methods used for the production of necrosis or inactivation of the myocardium, a new method employing low temperatures is described. Lesions, with complete necrosis of muscle cells, can be controlled as to size and can be selectively placed to involve any of the four cardiac chambers and the interventricular septum. This facilitates attempts to study chronic myocardial insufficiency in terms of quantity and location of damaged muscle. Also, it has been possible to produce disturbances in conduction by production of small interventricular septal lesions. Refined electrocardiographic analysis of the magnitude and location of ventricular lesions has not been possible.

ISSN:0009-7322    

出版商:OVID    

年代:1951

数据来源: OVID