ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Key WordsEditorials, insulin, diabetes mellitus.

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Key WordsEditorials, risk factors, angina.

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Key Wordsangioplasty, coronary disease, revascularization, balloon.

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

BackgroundThe ACE insertion/deletion (I/D) polymorphism is reported to be associated with myocardial infarction in both whites and Japanese. However, there have been no reports on the association of this polymorphism with stroke in each race. Furthermore, there are some racial differences in the demographics of cardiovascular diseases. In Japanese, stroke (especially that which occurs in preexisting hypertension) is more common and coronary artery disease much less common than in whites. We propose that the ACE I/D polymorphism might be associated with hypertensive cerebrovascular disease in Japanese.Methods and ResultsTo study the association between the ACE I/D polymorphism and hypertensive cerebrovascular disease, we identified the ACE I/D genotype in 228 hypertensive and 104 normotensive Japanese subjects. Compared with its frequency (0.31) in the 90 hypertensives without lacunae detected by magnetic resonance imaging, the ACE*D allele frequency was significantly higher (0.47; P < .001) in the 138 hypertensives with silent or clinically overt ischemic stroke, whereas there was no significant difference between its frequency in hypertensives without lacunae and in 104 normotensive control subjects (0.34). The positive association between the ACE I/D genotype and ischemic stroke in hypertensive patients was independent of other risk factors.ConclusionsWe found a positive association between the ACE*D allele and ischemic stroke in Japanese hypertensives in our study. The ACE*D allele may be an independent risk factor for the development of cerebrovascular disease in hypertensive patients. (Circulation. 1996;93:1630-1633.)Key Wordscerebrovascular disorders, enzymes, genes, hypertension.

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

BackgroundThe blood coagulation system is frequently activated in the acute phase of unstable angina, but it is unknown whether the augmented function of the hemostatic mechanism may serve as a marker of increased risk for an early unfavorable outcome.Methods and ResultsPlasma concentrations and 24-hour urinary excretion of fibrinopeptide A were prospectively determined in 150 patients with unstable angina. All patients underwent 24-hour Holter monitoring, during which time urine was collected; at the end of this period, a blood sample was taken and coronary arteriography was performed. The patients were followed up for the occurrence of cardiac events (death and myocardial infarction) until they underwent coronary revascularization or until they were discharged from the hospital. Fibrinopeptide A plasma levels and 24-hour urinary excretion were found to be abnormally elevated in 50% and 45% of the study population, respectively. During hospitalization, 11 patients developed myocardial infarction and 2 patients died. Kaplan-Meier analysis demonstrated a significantly higher probability of developing cardiac events in patients with abnormal rather than normal plasma levels of fibrinopeptide A (P < .01), whereas no difference in outcome was observed between patients with normal and those with abnormal 24-hour urinary excretion. Cox regression analysis showed that the only variables independently related to an early unfavorable outcome were the presence of persistent ischemia during 24-hour Holter monitoring (P < .0001), the presence of intracoronary thrombosis at angiography (P = .016), and abnormal fibrinopeptide A plasma levels (P = .038).ConclusionsPatients with unstable angina pectoris and abnormal fibrinopeptide A plasma levels are at increased risk for an early unfavorable outcome. (Circulation. 1996;93:1634-1639.)Key Wordsangina, thrombosis, prognosis.

ISSN:0009-7322    

出版商:OVID    

年代:1996

数据来源: OVID