摘要:

Microscopic lesions interpreted as representing early atherosclerosis were found in the aortas of most suckling rabbits. This is a period characterized by relatively high plasma lipid levels. In the postweaning period the lesions regressed. Fresh lesions reappeared in a significant number of adult rabbits of both sexes. Correlation with plasma lipid levels in the adult is less conclusive.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Iodide retards or prevents hypercholesterolemia and the development of experimental atherosclerosis in rabbits. "Protection" is estimated from reduction of plasma and/or hepatic cholesterol. Small doses of iodide do not "protect." Iodide in large doses prevents the hypercholesterolemia resulting from exogenous cholesterol and reduces hepatic cholesterol. This effect is independent of the thyroid gland and is not related to "thyroxin-like" plasma iodine. The influence of iodide on cholesterol metabolism seems to be related to the presence of a butanol-insoluble protein-bound iodine compound in the plasma.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

The fecal output of cholesterol and of noncholesterol sterols was determined in hyper- and hypo-thyroid rats, and in a group of control animals. The intestinal excretion of cholesterol and of total digitonin-precipitable sterols was found to be considerably increased in the hyperthyroid, and considerably decreased in the hypothyroid animals. The relationship of these findings to the altered plasmal cholesterol content occurring in deranged thyroid states is discussed.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Intra-arterial histamine was found to increase significantly the walking tolerance of a small series of cases of obliterative peripheral arterial disease with intermittent claudication. Physiologic determinations during injection show tachycardia, increased cardiac output, increased stroke volume and increased homolateral femoral arteriovenous oxygen difference. The similarity of these results to those caused by arteriovenous fistulas is noted.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Endarteriectomy is an operation originally proposed by Dos Santos in which a thrombus and the portion of the arterial wall to which it is attached are removed and the lumen of the artery re-established. The technic of this operation is described. Case histories of several patients illustrating the results which the authors have obtained are presented.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Nine cases of cerebrovascular thromboangiitis obliterans were observed among 1700 cases of peripheral thromboangiitis obliterans. These, with 30 acceptable cases from the literature, are analyzed. Smoking appears to activate the disease, which is characterized by, recurrences and remissions of focal cortical signs due to thrombosis of cerebral arteries and cortical granular atrophy. Of my patients, one died. Eight have been followed for 35 to 3 years, and with one exception all are ambulatory. Cessation of smoking is necessary. No other effective treatment is known.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

A short A-V conduction time, whether present with normal or with abnormal QRS complex, is associated with an increased incidence of paroxysmal rapid heart action. There are a considerable number of patients who have a short P-R interval, normal QRS complex and bouts of tachycardia. They are usually females, in middle life, devoid of organic heart disease and exhibit a snapping apical first heart sound. They do not demonstrate any of the features of anomalous A-V conduction. Evidence is presented suggesting the operation of endocrine and autonomic nervous system factors in the genesis both of the short P-R interval and the tachycardia.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Many physicians find it difficult to decide whether or not a patient sustaining a mild episode of acute myocardial infarction should be treated with anticoagulant drugs. The Committee for the Evaluation of Anticoagulants in the Treatment of Coronary Occlusion with Myocardial Infarction (American Heart Association) has recommended the employment of such therapy in patients with this disease, unless contraindications to anticoagulant therapy exist. Data are presented to show that in "good risk" patients treated conservatively without anticoagulants, the mortality rate and incidence of thromboembolism are strikingly low. Consequently, even the maximum benefit theoretically obtainable from the employment of dicumarol in these cases is not sufficient to justify the hazard entailed in its use. It is therefore recommended that anticoagulants be employed only in the more serious attacks of the disease.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

Reduction of the blood pressure in normal and hypertensive subjects by intravenous pyrogen caused the electrocardiograms to assume a more abnormal configuration as judged by present criteria of electrocardiographic normality. A temporary reduction of the blood pressure by the intravenous administration of tetraethylammonium chloride caused only minor and variable modifications of the electrocardiogram. The results of the experiments as done do not support the concept of strain as applied to certain electrocardiographic abnormalities which occur in the course of hypertension.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID

摘要:

A case of congenital aneurysmal defect of the ventricular septum is reported which appears to be unique in that this lesion was the only significant finding at autopsy. The patient had evidence of auriculoventricular block for a period of 26 years, at first partial and then complete. She succumbed at the age of 47 to a series of Adams-Stokes attacks which were demonstrated to be set off by paroxysmal ventricular flutter followed by ventricular tachycardia and ventricular standstill. Pertinent literature is briefly reviewed.

ISSN:0009-7322    

出版商:OVID    

年代:1952

数据来源: OVID