摘要:

One hundred and six patients in malignant stages of hypertension were treated with continuous oral hexamethonium chloride and 1-hydrazinophthalazine. The courses of ten uremic individuals were unaffected. Twenty-eight discontinued therapy, three of whom survived two months. Sixty-eight nonuremic patients continued treatment and 54 are alive 15 to 36 months later; 17 who were azotemic have lived two to three years. Of the 14 who died, only three succumbed to hypertensive complications. Forty-six of the living patients have returned to full activity. Apparently the malignant stage of hypertension is reversible by drugs properly used to lower blood pressure and no longer need be the rapidly fatal disease that it has been in the past.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

Studies were carried out regarding the effect of intravenous trypsin on rabbits. These included investigations into the toxicity and the tendency for the production of intravascular coagulation. The effect on artificial preformed thrombi was also observed. It was found that in the doses used, the intravenous administration of trypsin was not efficacious in the treatment of intravascular thrombosis. These studies failed to provide evidence to justify its use as a therapeutic agent in man.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

The intravenous injection of trypsin into rabbits resulted in marked changes in the rhythm and alteration in the P, QRS, S-T and T deflections of the electrocardiogram.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

A long-term experiment will be described which has shown that repeated injections of minute autogenous blood clots in rabbits caused pulmonary arteriosclerosis and cor pulmonale. Pulmonary arterial lesions were of two main kinds with respect to circumference of the intimal coat: eccentric, ascribable to intimal incorporation of clot, and circumferential, probably ascribable to hypertension and vasospasm. A counterpart to this animal experiment is probably to be found in human pathology, as suggested by certain case reports, by the pathology of lymphangitis carcinomatosa and by evidence that circulating blood is not clot free.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

In normal subjects hyperventilation causes a drop in arterial blood pressure, apparently because of the direct effect of hypocapnia on the peripheral vessels. In persons with disease of the autonomic nervous system, the drop in blood pressure is much greater because it is not effectively opposed by reflex vasoconstriction. Consequently, hyperventilation caused by anxiety may greatly intensify postural hypotension in such patients and contribute significantly to their disability. A pertinent case is reported.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

Adrenergic blocking with Dibenzyline measurably enhances the healing of ischemic ulcers. Eleven cases of obliterative arterial disease and two cases of Raynaud's disease were closely observed and are reported in detail. In six of the individuals suffering from obliterative arterial disease, changes in blood flow were documented by plethysmography. Dibenzyline measurably influenced intermittent claudication only after prolonged administration (three to four months) in four out of eight closely observed patients without ulcers. The results of the physiologic tests suggest that during the early phases of adrenergic blocking the increase in blood flow is mostly in the skin, while in the later phases increase in blood flow through the muscle predominates.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

Ilidar, a new adrenergic blocking drug, has been administered to 116 patients; follow-up was adequate on 86. The drug was highly effective in patients with predominantly vasospastic disorders and in patients with postphlebetic syndrome, and moderately effective in patients with thromboangiitis and arteriosclerosis. Most patients could tolerate 50 to 75 mg. three to four times a day. Side effects were principally those to be expected from the moderate postural hypotension associated with effective sympathetic blockade, namely, weakness, dizziness, nausea.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

Ninety-six per cent of the original subjects were traced after a period of 10 to 12 years; 202 were dead, and data obtained on re-examination were complete for 639. Except in one case of myocardial infarction, subjects with "borderline" or frank electrocardiographic abnormalities showed no symptoms of the development of heart disease. It is argued that the borderline abnormalities, considered as a group, must have little pathologic significance; otherwise, out of the relatively large number of subjects in this group, some would have exhibited symptoms. Although heart disease did not develop in any of the subjects with frank electrocardiographic abnormalities, such as bundle-branch block, the same argument does not hold with equal force because of the small number of cases in that group.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

The electrocardiograms of 5000 healthy adult male applicants for aircrew training have been reviewed. Abnormalities were observed in the tracings of 158 subjects and these were further investigated. T-wave abnormalities occurred in 95 applicants, prolongation of the QRS (including the Wolff-Parkinson-White syndrome) in 28, prolongation of the P-R interval in 23, and miscellaneous changes in a group of 12 men. In many instances the apparent abnormality could be explained as a variation of normal on repeat study (including multiple lead electrocardiograms). In 27 men (0.54 per cent), 15 of whom revealed some associated clinical cardiovascular findings, a significant abnormality persisted and these were considered as unfit for pilot training.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID

摘要:

Previous tests on the use of large doses of atropine for the treatment of anticholinesterase poisoning have revealed postural hypotension following the administration of 2 mg. of this drug. In this study on 78 normal adult males, the cardiovascular responses to positional change after 2 mg. atropine have been measured and the mechanisms elucidated. Blood pressure response to tilting was normal during control and placebo phases, but showed a profound alteration after atropine.

ISSN:0009-7322    

出版商:OVID    

年代:1954

数据来源: OVID