ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Quantitative studies of ventricular fusion beats were made in 40 patients with Stokes-Adams disease after implantation of electric pacemakers in the left ventricle. The two fusing complexes came from an electric pacemaker and either a second electric pacemaker or a conducted sinoatrial beat. The limit of fusion, that is the maximal time between two fusing complexes, gives a measure of the conduction time and velocity between the two points of initial ventricular depolarization.Conduction between two electric pacemakers and in retrograde direction from an electric pacemaker to the point of entry of a conducted beat was by way of ordinary myocardium; its velocity was about 1 meter per second. Conduction in antegrade direction, on the other hand, was by way of specialized Purkinje tissue; and its velocity was 4.5 to 9 times faster.Variations in conduction times with bundle-branch block support this interpretation: retrograde conduction time did not change; antegrade conduction time was prolonged in left but was usually unchanged in right bundle-branch block.The morphologic similarities of fusion beats in our patients to the features of anomalous AV excitation add strong evidence in man to the previous analogous experimental observations that the WPW complex is a fusion beat. Furthermore, quantitative comparison of WPW and our fusion beats supports the theory that the anomalous excitation in the WPW phenomenon, like the peripherally located artificial stimulus, enters the ventricle peripherally, by way of an accessory AV pathway.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood pressure averaging 48/18 mm. Hg was obtained.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Between 1945 and 1961 50 patients with aortic dissection were seen at the Mayo Clinic. Survival information for prognostic purposes was available in 40 patients and revealed that more than half of the patients were dead within a week. Of 15 patients who survived the acute phase (2 weeks) more than half were dead within a year. The cause of death was determined by necropsy in 24 patients and 22 died of external rupture of the dissecting aneurysm. In 11 patients a site of re-entry in the dissection was found and in all of these patients external aortic rupture had occurred also. The surgical approach to the treatment of aortic dissection is discussed in the light of these findings. The relationship of the location of the primary tear, blood pressure, and the age of the patient to prognosis is reviewed.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

Twelve patients were reverted from atrial fibrillation to sinus rhythm by the technic of “cardioversion.” Brief, light anesthesia was the only drug employed. Under conditions of comparable oxygen consumption cardiac output was measured first in atrial fibrillation and then in sinus rhythm. Eleven patients were studied at rest and five during exercise.Ten of the 11 patients studied at rest showed a reduced arteriovenous oxygen difference with sinus rhythm and seven of the 11 increased cardiac output 0.6 L./min. or greater, an average increase of 34 per cent. All five patients studied at exercise decreased the arteriovenous oxygen difference with sinus rhythm and cardiac output rose 1.1 L./min. or greater in all, an average increase of 17 per cent.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

By in vitro and in vivo bioassay methods, activity of plasma renin was studied in patients with acute tubular necrosis, polyarteritis, systemic lupus erythematosus, or the terminal stage of chronic renal disease.Plasma renin activity was increased during the oliguric phase of acute tubular necrosis, polyarteritis, or systemic lupus erythematosus; it was not increased during the diuretic phase of acute tubular necrosis and in the terminal stage of chronic renal disease.Acute reversible hypertension, observed in some patients during the oliguric phase of acute tubular necrosis, vas associated with a marked increase in plasma renin. A similar association was observed in hypertensive patients with polyarteritis or systemic lupus erythematosus, but not in hypertensive patients with the terminal stage of chronic renal disease. These data suggest that the renin mechanism may participate in the acute hypertension of acute tubular necrosis, polyarteritis, and systemic lupus erythematosus, but not in chronic hypertension in the present study.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID

摘要:

The hemodynamic alterations produced by large cerebral arteriovenous aneurysms are qualitatively similar to those caused by arteriovenousaneurysms elsewhere in the body. Congestive heart failure was not observed in our eight patients; it appears to be unusual in adult cases.By comparing cardiac outputs with a control group the mean aneurysm blood flow in six patients was estimated to be 2,804 ml. per minute at rest. Isoproterenol increased cardiac output relatively more than the estimated aneurysm flow.Implications of the present data with respect to the concept of “central” blood volume are discussed.Progressive mental and neurologic deterioration is the rule with large cerebral arteriovenous aneurysms. Repeated bleeding episodes, which may not be obvious clinically, appear to be partially responsible.

ISSN:0009-7322    

出版商:OVID    

年代:1965

数据来源: OVID