摘要:

p68 is an interferon-inducible protein kinase which is a key factor in the regulation of both viral and cellular protein synthesis. Since p68 plays a central role in cellular protein synthesis, we hypothesized that it would parallel translational activity, and thereby correlate with cellular differentiation in both normal and neoplastic cell types. Using the anti-p68 monoclonal antibody, TJ4C4, we have previously noted a correlation of p68 expression with the degree of cellular differentiation in the human upper aerodigestive tract and lung. During normal human fetal development, p68 is abundantly expressed in the upper aerodigestive tract and lungs, but considerably less so in the colon. In order to determine if this fetal expression pattern correlated with the pattern seen in adult colon and colonic adenocarcinomas, we analyzed the expression pattern of p68 in 80 patients with adenocarcinoma of the colon. Using light microscopic evaluation of immunoperoxi-dase-stained tissue sections, a spectrum of p68 expression was noted among the tissue samples. Increased p68 levels were noted in the majority of tumors with increased cellular differentiation, and those tissues with decreased p68 were, in general, less differentiated. These data are consistent with the concept that the expression of p68 parallels the degree of cellular differentiation, and are consistent with previously reported studies using this antibody. The limited fetal expression pattern of p68 in the colon and the variable correlation of p68 with differentiation suggests that p68, as well as other translational regulators, can be important in assessing the biological potential of tumors arising in the colon.

ISSN:1010-4283    

DOI:10.1159/000217945

出版商:S. Karger AG    

年代:1995

数据来源: Karger

摘要:

The serum levels of soluble interleukin-2 (sIL-2), sIL-2 receptors (sIL·2R), β2-microglobulin (β2M) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by the ELISA technique in 129 breast cancer patients and 40 controls. The median serum levels of sIL2-R, β2M and sICAM-1 were significantly higher and sIL-2 significantly lower than controls. sIL-2R, sICAM-1 and β2M levels were significantly higher in patients with metastatic disease compared to patients on long-term follow-up with no active disease. Initial study measurements of these markers could not identify patients at high risk for relapse. These findings suggest that the sIL-2R level is indicative of metastatic disease and together with other parameters of immune activation may be of help in monitoring disease activity in breast cancer pati

ISSN:1010-4283    

DOI:10.1159/000217946

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:1010-4283    

DOI:10.1159/000217947

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:1010-4283    

DOI:10.1159/000217948

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:1010-4283    

DOI:10.1159/000322191

出版商:S. Karger AG    

年代:1995

数据来源: Karger

ISSN:1010-4283    

DOI:10.1159/000217949

出版商:S. Karger AG    

年代:1995

数据来源: Karger