ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Background.The Cholestech L·D·X analyzer has the capability of performing a lipid profile in approximately 5 minutes. The purpose of this study was to determine analytical performance capability of the L·D·X to perform lipid profile measurements.Methods.Forty subjects gave two finger capillary samples and one venous serum which were analyzed in duplicate by two technicians, on two different L·D·X analyzers. A local pathology laboratory was used as the standard for accuracy comparisons. Two controls with known values were provided by the manufacturer to assess within-day precision. Day-to-day precision was determined by analyzing high (240 mg/dL−1total cholesterol (TC) and 60 mg/dL−1high-density lipoprotein [HDL]) and low (200 mg/dL−1TC and 35 mg/dL−1HDL) human serum samples on 10 different days.Results.Analysis of variance procedures revealed no significant differences between the two technicians or the two analyzers, nor among the fingerstick, venous serum, or reference measures for any of the analytes. The total error of measurement of TC, triglycerides, and HDL measurements were 6.3 to 16.2%, 14.8 to 30.8%, and 11.5 to 26.8%, respectively. In comparison to the National Cholesterol Education Program (NCEP) desirable, borderline-high, and high classifications obtained from the reference laboratory the L·D·X TC results were correctly classified in 92.5% of the cases. L·D·X triglyceride classifications of desirable, borderline hypertyglyceridemia, and distinct hypertriglyceridemia matched 100% with the classifications obtained from the reference laboratory.Conclusions.Although the Cholestech L·D·X analyzer did not consistently meet NCEP standards for acceptable total measurement error of TC, HDL, and triglyceride analyses, it seems capable of providing reasonable lipid profile measures in both a screening setting and a clinician office where the goal is correct classification of patients' results.

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Background.After myocardial infarction, women have higher rates of recurrent coronary events than men. This is caused, at least in part, by a higher prevalence of obesity-related coronary risk factors such as hyperlipidemia, hypertension, sedentary lifestyle, insulin resistance, and diabetes. We studied the relationship between measures of body fat distribution, body composition, aerobic fitness, and dietary intake and several coronary risk factors including lipids, glucose, and insulin levels.Methods.The study population included 20 women > 60 years of age with recently diagnosed coronary heart disease and a comparison group of 50 healthy women with low-risk coronary risk profiles. Dependent variables included lipid subfractions (fasting, triglycerides, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein [LDL] cholesterol), glucose levels, and serum insulin levels.Results.Waist-to-hip ratio (WHR) was the best predictor of serum triglyceride levels (r = .65, P = .002), HDL cholesterol level (r = .46, P = .05), and fasting serum insulin levels (r = .76, P < .001) whereas peak oxygen consumption (Peak V02) was the best predictor of LDL cholesterol (r = .73, P < .001). In a combined population of the 20 coronary patients and 50 healthy age-matched controls, WHR remained the best predictor of serum triglyceride levels (r = .57, P < .001) and insulin levels (r = .63, P <.001) and Peak V02was the best predictor of HDL (r = .40, P < .001) and LDL cholesterol (r = .57, P = .004).Conclusions.Body fat distribution and peak aerobic fitness, both modifiable factors, are significant predictors of risk factors for second coronary events in older female coronary patients.

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0883-9212    

出版商:OVID    

年代:1997

数据来源: OVID