摘要:

555 individuals were examined in relation to the ABO (with A1 and A2 subtypes), MNSs, P, Rh, Lutheran, Kell and Duffy systems. Less individuals were studied for the Kidd and Diego systems as well as for transferrins, haptoglobins and red cell enzymes, i.e. PGM1, 6-PGD, AK, and AcP. Besides, several Gm and Km (1) factors were also studied.

ISSN:0001-5652    

DOI:10.1159/000152973

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

In this work, we present new data on the Hp1α- and Hp2α-chains polymorphism in different populations. We confirm the singularity of the geographical distribution of the Hp2 alleles in our samples. The analysis of the results shows that a significant correlation exists in the population between the Hp1S and Hp2 gene frequencies. An additional Hp1α-chain variant is described in a Pyrenean samp

ISSN:0001-5652    

DOI:10.1159/000152974

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The F-bodies of two-headed human spermatozoa offer a unique potential for estimating non-disjunction rate of the Y chromosome. But there is an unexplained quantitative discrepancy: a gross deficiency of two-headed spermatozoa with no F-bodies, relative to the numbers with one F-body in each head. Any estimation of non-disjunction rate would be overshadowed by this and other major factors. Two-headed spermatozoa cannot be regarded as a random aggregation of haploid heads in pairs. DNA measurements confirmed that each head of 25 normal-sized two-headed spermatozoa was haploid. The distribution of F-body classes is independent of whether sperm tails are single or double. Donors with an exceptionally high incidence of two-headed spermatozoa exist.

ISSN:0001-5652    

DOI:10.1159/000152975

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Three genetic markers – group-specific component (Gc), α1-antitrypsin, and esterase D – were examined in a population of Eskimos from Igloohk in the eastern Canadian Arctic. Gc and esterase D were found to be polymorphic. In addition to the common Gc types, an anodal variant called Gc Igloolik was found, probably identical to previously reported Gc Eskimo. Gene frequencies were Gc1: 0.6524, Gc2: 0.3373, GcIgl: 0.0104, for 338 Eskimos. Genetic types of α1-antitrypsin (Pi types) were mostly M, with two MS sibs who were half Caucasian, in 170 Eskimos. Frequencies of the esterase D allele in 336 Eskimos were EsD1: 0.7083, EsD2: 0.2917. The frequencies of Gc2 and EsD2 are both higher than are found in Caucasian popula

ISSN:0001-5652    

DOI:10.1159/000152976

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Factor analysis was employed using the ulnar ridge count, radial ridge count, ridge count (the larger of the radial or ulnar count as generally used for calculating total ridge count), and pattern type for each finger in 720 twins. Pattern type and ulnar count displayed parallel factor loadings while loadings for radial and ridge count also paralleled each other. This relationship did not hold for the index finger, indicating the importance of pattern direction and greater pattern diversity for this digit. Total ridge count was most closely associated with a factor of ring and little finger radial and ridge count and only secondarily with an index finger factor. When radial and ulnar counts were deleted to make comparisons with earlier studies, the result was factors having groupings of variables identical with previous reports. It appears that factor analysis results in consistent extraction of identical or very similar factors from different populations, and the use of radial and ulnar counts adds more information than when only the larger of the two counts is considered.

ISSN:0001-5652    

DOI:10.1159/000152977

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The increase of parental consanguinity in multifactorial inheritance is evaluated by calculating the expected incidence of affected children whose parents are first cousins, using several values, namely for condition frequency and heritability of liability. This increase is compared to the expected increase in recessive inheritance, when one or more loci are involved. The method is illustrated by examples of recessive and multifactorial conditions and applied, as a test of discrimination between different modes of inheritance, to data on congenital glaucoma.

ISSN:0001-5652    

DOI:10.1159/000152978

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Inherited genetic markers on the immunoglobulins and three other serum proteins were investigated in members of an isolated Newfoundland community. The frequencies found were compared with those from Europe. Whilst the incidence of the commonest variant forms were typically ‘European’, the occurrence of rare phenotypes pointed towards specific admixture from American Indians and Scandinavia. A possible contribution of these rare alleles, and of others, to pathogenesis in a familial aggregate of Hodgkin’s disease within this community is disc

ISSN:0001-5652    

DOI:10.1159/000152979

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The genetic distances between the American Indians and the three major races of man, Caucasoids, Negroids and Mongoloids, were determined by using gene frequency data on 14 blood group and 12 protein loci. The results support the general view that the ancestry of the American Indian is predominantly Mongoloid. Using 30,000 years as the separation time between the American Indian and Mongoloid, the divergence time between the three major races of man was estimated to be 33,000–92,000 year

ISSN:0001-5652    

DOI:10.1159/000152980

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A Brazilian island with a total population of 307 inhabitants (sex ratio 89.5) was found to have a breeding population of 104 and an effective number of 94. Its total migration rate is 0.25 and the migration rate of its breeding population is 0.33. The corresponding effective migration rates are 0.18 and 0.29, respectively. Short-range migrants are 0.17–0.26, long-range ones 0.07–0.14. The whole population presents a marital distance of 88 km and a migrational distance of 68 km. Among consanguineous parties, these distances are lower than 1 km. The observed (estimated from pedigrees) inbreeding coefficient equals 0.0015, a value 5–9 times lower than theoretically expected (from 0.0077 to 0.0133, say roughly 0.01). It is also lower than those of other (inland) populations with about the same migrational rate. The inbreeding coefficient of the offspring of the consanguineous couples is also very low (0.0071). It is possible that the prevailing mating pattern on the island may be responsible for such avoidance of inbreeding. The value 0.01 is an estimate of the coefficient of kinship of the population. Prenatal mortality equals 8%; infant mortality 10%; mortality from birth up to the age of 20 is 18%. The average number of live-born children per woman at least 40 years old is 7.80. The frequency of twin births is

ISSN:0001-5652    

DOI:10.1159/000152981

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Family studies in Newfoundland confirm linkage between the glyoxalase I locus and HLA. The combined data gives a map distance of 4.54 centimorgans between the HLA B locus and glyoxalase I.

ISSN:0001-5652    

DOI:10.1159/000152982

出版商:S. Karger AG    

年代:1978

数据来源: Karger