摘要:

Phenotyping of plasma plasminogen (PLG) was carried out by the method of agarose gel isoelectric focusing followed by immunofixation or immunoblotting. The allele frequencies calculated from healthy Japanese individuals (n = 795) were as follows: PLG*1 = 0.9440, PLG*2 = 0.0189, PLG*A = 0.0076, PLG*A2 = 0.0006, PLG*B = 0.0138, PLG*B2 = 0.0013, and PLG*C = 0.0138. The PLG phenotype distribution in a group of patients with cerebral infarction (n = 125) was also studied. The allele frequencies were PLG*1 = 0.960, PLG*2 = 0.016, PLG*A = 0.012, and PLG*B = 0.012. No statistically significant association was found between PLG types and cerebral infarction.

ISSN:0001-5652    

DOI:10.1159/000153617

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

We have previously described a general pattern of homogeneity in genetic and cultural determinants of blood lipids and lipoproteins among the major origin groups in the Israeli population. This paper reports on these determinants of total plasma cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), and of the HDL-C/TC ratio, estimated from the total sample of 4,000 families whose members were examined in the Jerusalem Lipid Research Clinic. Both genetic (h2) and cultural (c2) components of inheritance were significant for all lipid variables. Under the most parsimonious model genetic heritability (h2) ranges from 0.45 for LDL-C, 0.47 for HDL-C to 0.64 for HDL-C/TC ratio. Cultural heritability (c2) was 0.03 for LDL-C, 0.04 for TC, 0.05 for TG and 0.07 for HDL-C and HDL-C/TC ratio. Within this population, as in others, genetic factors appear to be the major determinants of lipid variation, suggesting relative homogeneity of environmental correlates of plasma lipids.

ISSN:0001-5652    

DOI:10.1159/000153618

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A total of 461 individuals, belonging to some Subsaharan populations (Beti, Bateke and Babenga Pygmies of Congo; Goun and Nago of Benin; Mbugu and Sango of the Central African Republic), and a sample of 231 individuals of the population of Rome (Italy) have been typed for red cell esterase D using conventional electrophoresis and isoelectric focusing. The Subsaharan populations showed a high variability of the frequency of the EsD2 allele (0.018–0.138) and the absence of the EsD5 allele which, on the contrary, reached a polymorphic frequency (0.017) in the Italian sample. These results suggest that the EsD5 allele has a Caucasian origin.

ISSN:0001-5652    

DOI:10.1159/000153619

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The rate change of gene frequency in a population subject to emigration obviously depends on differences in the effective reproductive size (and resulting random genetic drift effects) between emigrants and natives. An important additional force may be the different selection pressures of the original and the new environment into which the population penetrates. Discrete traits and monolocus systems have been studied in many natural populations of various species. However, knowledge about the migration influence on quantitative, i.e. polygenic, characters is very limited. The present study set out to answer the following biological questions: (1) Does migration induce changes in sets of phenotypic, genetic and environmental correlations? (2) If so, are these changes expressed in levels and/or structure of the correlation matrices? Data on 20 anthropometric traits in 305 Mexican families [129 families from Mexico (sedentary population) and 176 families living in Texas (migrant population)] were used for analysis. The curves of distribution and average values of phenotypic, genetic and environmental correlations remained unchanged between the two populations. However, qualitatively (i.e., as far as the agreement between matrix compositions is concerned), all three matrices changed significantly. The phenotypic correlations appear to be the most highly canalized, the correspondence between the two matrices being 62.1 %. The environmental matrices had the highest variation, and although 26.3 % of the correlations were in agreement, this was statistically nonsignificant. The most important finding in the present study was the relatively low correspondence between the two genetic matrices (35.6%). We suggest that these changes were provoked by preselection (i.e., by a nonrandom sample) of migraiting individuals.

ISSN:0001-5652    

DOI:10.1159/000153620

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Genetic polymorphism of 16 red-cell antigens, enzymes, serum proteins and Hb variants was investigated in 214 male and female individuals belonging to the Meiteis and a Brahmin caste group living in Imphal (Manipur, Northeast India). Ethno-historical records suggest that the Meiteis are of Mongoloid origin, while the original Brahmin settlers represent the easternmost part of the so-called Caucasoids. The markers studied are: A1A2BO, MNSs, Rh-system, Duffy, Diego; Gm, Km, Gc, Hp, Tf, Cp; Hb; aP, AK, EsD and LDH. The comparison between the two groups on the basis of the markers studied showed that the Meiteis and Brahmins are very close to each other with respect to most of the loci except Gm, EsD and Hb, where significant statistical differences were found.

ISSN:0001-5652    

DOI:10.1159/000153621

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

In a sample of 4,472 boys, aged 17–18 years, resident in Jerusalem, those with blood groups B or AB tended to be slightly shorter than groups·and A (p = 0.011). Participants were classified into 8 groups according to father’s country of origin: Israel, Southern Europe/Balkans, rest of Europe, North Africa, Iraq, Iran, Yemen and the rest of Asia. The association of ABO blood group, classified according to the presence of the B antigen (groups B and AB) or its absence (O and A), with height differed in the 8 origin groups (p ≈ 0.026 for interaction). In 7 of the 8 groups, subjects with the B allele were either shorter or of equal height to groups·and A and in only one instance were they taller. These findings do not support the generalizability of a positive association of the presence of the B antigen with height suggested by Borecki et al.

ISSN:0001-5652    

DOI:10.1159/000153622

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Frequencies of the three common subtypes of PI M were studied in a Jordanian population. In comparison with other populations, PI*M3 was found to be low (0.038) and PI*M2 rather high (0.155).

ISSN:0001-5652    

DOI:10.1159/000153623

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Genetic polymorphism of I(C3b/C4b inactivator) was studied by the method of agarose gel isoelectric focusing followed by an immunoblotting technique. Serum or plasma samples were pretreated with neuraminidase. The method is rapid, and gives the simple and reliable patterns of I. The allele frequencies calculated from healthy Japanese individuals living in the western part of Japan were: IF*A = 0.126 and IF*B = 0.874.

ISSN:0001-5652    

DOI:10.1159/000153624

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A sample of the South Sardinia population was studied with respect to acid phosphatase (AcP) and esterase D (EsD) enzymes. The gene frequencies were: AcPA = 0.326, AcPB = 0.607, AcPC = 0.067 and EsD1 = 0.883. The results were compared with those of other Italian populations.

ISSN:0001-5652    

DOI:10.1159/000153625

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0001-5652    

DOI:10.1159/000153626

出版商:S. Karger AG    

年代:1986

数据来源: Karger