摘要:

Heterogeneity in the source of familial resemblance for high-density lipoprotein (HDL) cholesterol in 5 different Lipid Research Clinics (Cincinnati, Iowa, Minnesota, Oklahoma and Stanford) was assessed using a general linear model for cultural and biological inheritance. No evidence of heterogeneity was found in any of the parameters of the model. Under the most parsimonious hypothesis, using data pooled over all clinics, genetic and cultural heritability were both significant and were estimated to be 0.52 ± 0.04 and 0.09 ± 0.02, respectively; there was cultural transmission but no maternal effects; marital and nontransmitted sibship environmental resemblance were significan

ISSN:0001-5652    

DOI:10.1159/000153868

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Plasma specimens from 2,010 blood donors resident throughout the island State of Tasmania, Australia, were examined for group-specific component (GC) subtypes using polyacrylamide gel iso-electric focusing. Subdivision of the island into 8 geographic regions revealed no significant heterogeneity. Comparison of GC allele frequencies with those reported in mainland Australian populations indicated that Tasmanian values lie well within the ranges previously reported.

ISSN:0001-5652    

DOI:10.1159/000153869

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Two population groups in South Korea, one from Kwangju and one from Kangreung, were studied in regard to the erythrocyte enzyme polymorphisms GPT, ACP, GLO, ESD, 6PGD, ADA, AK, PGP and subtypes of PGM1 as well as regarding the serum protein variants of C3, HP, BF, PLG, AMY and the subtypes of GC, TF and PI. The results were compared with data of the population groups from the area of Cheju Island, Taejon and Seoul. The Korean population showed a rather high degree of genetic homogeneity.

ISSN:0001-5652    

DOI:10.1159/000153870

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

This study investigated the consanguinity rate of 233 families with severely disturbed reproductive health, and compared it to that of 227 families with normal (moderate) levels of reproductive wastage and to that of 155 families with no reproductive disturbance. The results showed that the inbreeding coefficients of the three groups of families were 0.0358, 0.0241 and 0.0208, respectively. Furthermore, the rate of congenital malformations was found to be highly correlated with the consanguinity rate of these families.

ISSN:0001-5652    

DOI:10.1159/000153871

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

To study the evolutionary relationships of the three major groups of humans, Europeans, Asians and Africans, the genetic distances between them were computed by using 4 different sets of genetic loci (84 protein loci, 33 blood group loci, 8 HLA and immunoglobulin loci, and 61 DNA markers). The results obtained indicate that the overall genetic distance between Europeans and Asians is significantly lower than that between Europeans and Africans or that between Asians and Africans and support the hypothesis of an African origin of modern humans. This seems to be the first study to establish the evolutionary relationships of the three major groups of humans at a statistically significant level.

ISSN:0001-5652    

DOI:10.1159/000153872

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Four polymorphic sites of the short arm of the X chromosome were studied in two racial groups from India, the Assamese and the Malayalee. Since the allelic frequencies of the two groups did not differ markedly from each other, the data from the two populations were pooled. The frequency of the A2 allele was 0.57 for the L1.28 probe, 0.20 for the RC8 probe, 0.28 for the pD2 probe and 0.11 for the L754 probe. The A3 allelic fragment of the RC8 probe was not found among 67 Indians, and in one Assamese woman an additional 7.0-kilobase fragment was found. The differences between the Indian population and other ethnic groups were analyzed.

ISSN:0001-5652    

DOI:10.1159/000153873

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

A new rare mutant of the red-cell acid phosphatase (ACP1) is described using conventional gel electrophoresis and isoelectric focusing migration. According to the electrophoretic patterns obtained, the new mutant ACP1 * KUK is different from the ACP* H and ACP1* A’ variants already described. The enzyme activities and the thermostability curves definitively confirm the existence of a new variant. The transmission of this mutant was followed through a pedigree of three generations. The family originated from Czechoslovakia. The frequency of the variant is probably less than 0.00

ISSN:0001-5652    

DOI:10.1159/000153874

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

In order to investigate the interzeta-globin gene hypervariable regions (IZHVR) in Chinese, DNA samples from 114 unrelated normal individuals were analyzed using the restriction endonuclease BglII and hybridized with a 32P-labeled ζ-globin probe. Four polymorphic fragments containing IZHVR with different frequencies were found: 11.3 kb, 0.24; 10.8 kb, 0.50; 10.4 kb, 0.05, and 10.0 kb, 0.21. Using these polymorphic fragments as linkage markers, we were able to trace the affected siblings in a three-generation Chinese family with a history of adult polycystic kidney disease

ISSN:0001-5652    

DOI:10.1159/000153875

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Most patients with Zellweger syndrome, neonatal adrenoleukodystrophy, infantile Refsum disease and hyperpipecolic acidemia are characterized by a deficiency of peroxisomes. We have developed a simple cytological method for the in situ detection of genetic complementation among and between these patients who are clinically and biochemically defined as having generalized peroxisomal dysfunction. This technique should facilitate both complementation studies in these disorders and investigations into the biogenesis of peroxisomes.

ISSN:0001-5652    

DOI:10.1159/000153876

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Genetic variants of human apolipoprotein A-IV (ApoA-IV) were investigated in 614 healthy Japanese individuals. The allele frequencies were estimated as ApoA-IV*1 = 0.9984 and ApoA-IV*2 = 0.0016. In addition, a new variant ApoA-IV*To-kyo was observed in a paternity material.

ISSN:0001-5652    

DOI:10.1159/000153877

出版商:S. Karger AG    

年代:1989

数据来源: Karger