摘要:

The expected frequency among relatives of ascertained individuals for a threshold trait with multifactorial inheritance is presen ted for the upper range of population frequency. Expected values of various measures of concordance in twins are also derived.

ISSN:0001-5652    

DOI:10.1159/000152476

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Sources of variation in blood clotting factors I, II, V, VII, VIII, IX, X, XI and XII have been investigated in a series of adult male twin pairs. Estimates of components of variation are presented, together with other sample statistics. The study emphasizes the importance of technical and experimental vari ation in the determination of the levels of most factors, and the relative unimportance of genetical and other familial factors in the variation of factors I, II and XI. The difficulties of interpretation of the genetical component of variation of the other factors are discussed.

ISSN:0001-5652    

DOI:10.1159/000152477

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The study of 1,785 persons of different racial groups in Malaysia revealed that the haemoglobin X com ponent (earlier reported as leading to Hb H disease when combined with α-thalassaemia) is present in the general population in appreciable frequencies: 2.24% in 536 Malays; 0.66% in 607 Chinese; and 0.16% in 642 Indians. The gene responsible for the haemoglobin abnormality is inherited as an autosomal codominant gene. This slow-moving component may be the same or similar to those described in α-thalassaemia from Greece and Thailand and in Chinese from Jamaica and the U

ISSN:0001-5652    

DOI:10.1159/000152478

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Hypothetical immunogenetic universes containing only three different classes of fundamental immunogenetic units (aggs, ants and antis) are given. An obligatory one one relation exists between these units, whereby definable many-many relations are obtained between genes, antigens and antibodies consisting of combinations of these fundamental units. Different serological universes (S-Y) are defined and found to require only a very small number of different fundamental units to account for most immunogenetic systems even at a fairly sophisticated level of knowledge. The article represents a first attempt towards a unifying concept of immunogenetic systems and serological reactions in general.

ISSN:0001-5652    

DOI:10.1159/000152479

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

A serological model, a mathematical analysis of this model as well as experimental serological evidence, have all made it highly probable that serological relatedness between antibodies defining basic antigens (at least within the same genetic system) is a very common phenomenon. The consequences of this antibody ‘relatedness’ to conventional genetic theory formation based on the assumption of unrelated antibodies is briefly discussed. It is shown that a relation between antibodies could falsely be interpreted as being instead a relation between antigens on a genetic, biochemical and/or serological le

ISSN:0001-5652    

DOI:10.1159/000152480

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The distributions of Gm(a, x, f, b, c, g, and t) and Inv(l) allotypic markers have been examined in 512 Chinese classified as to province of origin. The results indi cate a south to north cline, extending from southernmost to northern China in which Gmag changes from 0.12 to 0.55, Gmaxg from 0.04 to 0.15, Gmabst from 0.04 to 0.12 and Gmafb from 0.80 to 0.22. In contrast to the Gm system, there does not appear to be any significant regional variation in the frequency of Inv1 among Chinese.

ISSN:0001-5652    

DOI:10.1159/000152481

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The distribution of the Gm(axgfb1b3,c3c5 and t) and Inv(l) allotypic markers have been examined in 211 Koreans. The results indicate that the Korean Gm allogroup frequencies are intermediate between the Japanese and northern Chinese. However, there do not appear to be significant differences in the frequencies of Inv1 between Chinese, Japanese and Koreans.

ISSN:0001-5652    

DOI:10.1159/000152482

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Dermatoglyphic patterns of the Bush-Bantu hybrids of Pandamatenga, Botswana, reveal affinities of the group to Bushmen and, perhaps by virtue of this relationship, Pygmies, thus confirming the serogenetical findings on this group. In certain respects these hybrids take an intermediate position between Northern Bushmen on the one hand, and Southern plus Central Bushmen on the other. Pattern frequency in the thenar/first interdigital space of the palm is distinctly different to that in Bushmen, a finding which is compatible with a simple mode of inheritance for this trait. Affinity with the Mongoloid race is suggested by some of the pattern traits. Finger ridge counts reveal certain differences between the Pandamatenga hybrids and Caucasoids. The mean total count is lower in the African group than in the British sample with which it is compared. The difference is most marked in males. The sexual dimorphism which characterises the British sample (in which the mean total ridge count is significantly higher in males than in females) is not present in the hybrids. This may be related to a general trend to feminization and paedomorphism in the Bushmen. The possibility of sex chromosomal uniqueness to account for this trend warrants consideration.

ISSN:0001-5652    

DOI:10.1159/000152483

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The red cell adenylatekinase (AK) phenotype has been determined in a sample of about 600 subjects from southern India. An abnormal electrophoretic pattern has been described. Family data support the hypothesis of the existance of a new variant allele, AK5 at the AK locus.

ISSN:0001-5652    

DOI:10.1159/000152484

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Serum haptoglobin and transferrin polymorphisms were studied at birth and at one year of age in a cohort of infants born in Puerto Rico, and also in their mothers. The frequency of hypohaptoglobinemia in the newborn was found to be 86%. Quantitative studies confirmed that hypohaptoglobinemia rather than complete absence of haptoglobin activity existed in the newborns. Our observations on the effect of parity on this condition did not support the hypothesis that fetalmaternal incompatibility, for haptoglobin types, accounts for hypohaptoglobinemia of the newborn. Phenotype and gene frequencies for these serum polymorphisms are presented for these samples. Variation in the transferrin system was contributed by TfD alleles, probably TfD1. The data presented here represent the first observations of the serum transferrin and haptoglobin polymorphisms for the island of Puerto Rico.

ISSN:0001-5652    

DOI:10.1159/000152485

出版商:S. Karger AG    

年代:1972

数据来源: Karger