摘要:

Eryhtrocyte glutathione peroxidase (GSH-Px) was assayed in subjects of Mediterranean origin and the distribution of the data obtained seems to confirm the existence of two alleles coding for low and high enzyme activity. In order to define the limits of expected genotypes less arbitrarily we studied families where parents’ genotypes could allow us to define that of the children. Gene frequencies were calculated from genotype frequencies of an unrelated population and from crossings distribution by the Hardy-Weinberg equation. We observed a good agreement between gene frequencies obtained by these two different method

ISSN:0001-5652    

DOI:10.1159/000153450

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Finger and palm prints were collected from 306 Nepalese males belonging to the Kiranti, Gurung and Mangar tribes of Nepal. The dermatoglyphic characteristics show affinities with other Asiatic Mongoloid populations especially those residing in the southern Himalayas.

ISSN:0001-5652    

DOI:10.1159/000153451

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Red cell esterase D (EsD) phenotypes were determined in a Danish population sample of 3,116 unrelated adults by starch-gel electrophoresis. A new phenotype was discovered, which appeared to be determined by the EsD1 allele and a new allele EsDcPh. The gene frequencies observed were EsD1 = 0.9007, EsD2 = 0.0992, EsDCPh = 0.0001. Investigation of 1,111 mother-child pairs and 59 families with 157 offspring added further support to the genetic model of two common alleles at an autosomal locus. The applicability of the EsD polymorphism to paternity testing was investigated on 960 cases of disputed paternity. An estimate of the EsD null allele frequency (0.001) in European populations was made on the basis of observations made on 5,864 mother/ child combinations and 762 matings with 1,882 offspring. The influence of this allele on the reliability of exclusions of paternity was determined.

ISSN:0001-5652    

DOI:10.1159/000153452

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Hexokinase-1 (HKl) activity was determined in red cells of 5 patients with partial duplications of chromosome 10, all of which involved the lOp region. In 4 patients the levels of HKl activity were higher than the mean activity of controls, strongly indicating a triplex dosage effect. The most likely regional assignment for HKl would appear to be 1 Op 11.2.

ISSN:0001-5652    

DOI:10.1159/000153453

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A procedure for estimating HLA phenotype frequencies from two- and three-locus haplotype frequencies is described. Formulae for this procedure are derived, and examples are presented to illustrate the application. The procedure is useful when multiple-locus phenotype frequencies from a laboratory control series are not available, or when a sufficiently large number of laboratory controls have not yet been typed for recently defined antigens or loci to yield stable multiple-locus rates for comparative purposes.

ISSN:0001-5652    

DOI:10.1159/000153454

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Six different serum group systems (Bf, C3, Gc, Hp, Pi and Tf) were studied in a series of patients from northern Sweden with abdominal aortic aneurysms. In the haptoglobin system an increased frequency of the Hp 2–1 type was observed among the patients. No association was found between abdominal aortic aneurysms and the other five serum group system

ISSN:0001-5652    

DOI:10.1159/000153455

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Differential mortality as a function of birth weight was studied in newborns up to the 1st week of life in Visakhapatnam, Andhra Pradesh (India). It was found that both selection intensity and selective deaths were higher than in other studies. Furthermore, in the present study the values obtained were higher for female than for male newborns.

ISSN:0001-5652    

DOI:10.1159/000153456

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Gc types were examined in a total of 1,000 unrelated Japanese individuals from Western Japan. By isoelectric focusing the six common subtypes and several rare types were observed. In addition, a new variant with a mobility between the Gc 1S and 1C2 was identified in 2 individuals. A family investigation confirmed the inheritance of the corresponding allele Gc*1C35.

ISSN:0001-5652    

DOI:10.1159/000153457

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Chromosomal aberrations were studied in lymphocytes of 15 workers exposed to styrene and 13 controls. The average styrene concentration in the work room air was 24 ppm, and the levels of urinary mandelic acid were below 2 mmol/l. No significant increase in the rates of gaps and breaks was found. However, the rate of micro-nuclei was significantly increased, which indicates that the mitotic spindle mechanism may be more sensitive to styrene and its metabolites than DNA.

ISSN:0001-5652    

DOI:10.1159/000153458

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Four different populations of China were studied regarding aldehyde dehydrogenase isozyme variation and incidence of alcohol sensitivity. While Korean and Mongolian minorities in the north showed an isozyme I deficiency with a frequency of about 25 and 30%, 45–50% of Zhuang and Han were deficient, respectively. Adverse reactions after alcohol drinking were mainly reported by those subjects who showed the lack of aldehyde dehydrogenase isozyme

ISSN:0001-5652    

DOI:10.1159/000153459

出版商:S. Karger AG    

年代:1984

数据来源: Karger