摘要:

The relations between serum lipids, ABO and Lewis blood groups and alkaline phosphatase isozymes were studied in a series of 291 Swedish military conscripts. The level of esterified cholesterol was significantly higher in individuals of blood group A compared to those of blood groups AB and O. The correlation between blood groups and esterified cholesterol was most likely not mediated through intestinal alkaline phosphatase, since no significant correlations were found between the levels of serum lipids and that of the intestinal alkaline phosphatase isozyme. The levels of all serum lipids examined and particularly that of the triglycerides showed a significant negative correlation with the level of the liver alkaline phosphatase isozyme.

ISSN:0001-5652    

DOI:10.1159/000152362

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

(1) Incidence. Through the analysis of 35,868 children born to white couples (W), in urban and rural zones of the States of Minas Gerais, Parana and Santa Catarina, the incidence of cleft lip with or without cleft palate (CL ± CP) was found to be 0.84 ± 0.15°/00. Among 33,263 non-whites (mulattoes and negroes: NW) surveyed in the same regions, this frequency was 0.69 ± 0.14°/00. These data show a general agreement to those obtained in other W and NW populations. The frequency of isolate cleft palate (CP) was found to be 0.06 ± 0.04°/00 both among W and NW. (2) Etiology. Our data on CL ± CP agree with the hypothesis of a multifactorial inheritance but they do not support the view of a sex modified inheritance. The fact that the incidence and the recurrence risks have the same order of magnitude in Brazilian populations characterized by low socio-economic level as those verified in developed countries may be accepted as an indication that exogeneous factors (such as those prevalent in our underdeveloped populations) are not important as etiologic factors.(3) Recurrence. The risk of recurrence of CL ± CP for sibs with normal parents is 3–4% in the Caucasian fraction. Among 79 NW sibs, no CL ± CP cases were verified. In 5 sibships (3 W and 2 NW) with 1 affected parent, no recurrence was verified in a total of 20 children. In two W families, with a total of 5 sibships, where CL ± CP had a familial character, the recurrence among sibs was 7%. This value however does not differ statistically from the general risk (around 4%).(4) Inbreeding. The incidence of consanguineous marriages is larger among the parents of CL ± CP children than in the general population, although the difference is not statistically significant. No recurrence has been verified among inbred individuals. (5) Genetic load. An estimate of the mean number of abnormal (CL ± CP) equivalents per gamete (B) among Caucasians revealed 0.01 ± 0.01 and among NW 0.01 ± 0.02. These values are not significantly different from zero; B/A∼16. (6) Maternal age and parity. Our data do not show any effect in relation to these parameters. (7) Sex-ratio. Our data show a statistically non-significant excess of affected

ISSN:0001-5652    

DOI:10.1159/000152363

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Two pedigrees from Kerala and data on 274 families from 4 states in India have been reported here along with some population data on tongue pigmentation. Analysis of the pedigrees and sibships reported here and previously, revealed that neither an autosomal dominant, nor a sex-linked, a sex-limited, or a non-genetic chance hypothesis could interpret the data. Tests for segregations in the families support the genetic hypothesis that tongue pigmentation is an autosomal recessive character in human populations governed by 2 allelic genes, the ‘normal’ allele (A) being dominant over the ‘pigmented’ allele (a). There are certain indications which suggest occasional failures of penetrance of the tongue pigmentation

ISSN:0001-5652    

DOI:10.1159/000152364

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

As previous studies have given support to the assumption that tongue pigmentation in man is inherited as a simple autosomal recessive character [Rao, 1970], an attempt has been made in this study to (1) test for sex-differences in the trait, and (2) investigate whether there is any association between this trait and mental ability. The present study reveals that there are no sex-differences nor any relation between this trait and mental ability as determined here.

ISSN:0001-5652    

DOI:10.1159/000152365

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Palmar prints of 528 individuals (336 males and 192 females) have been studied for intertriradial intervals a–b, b–c, c–d and a–d to investigate the differences between the main groups among the Newars of Nepal, viz. Shrestha, Gubhaju and Jyapu. The mean values for the ridge-counts of all the 4 areas have been observed to be highest in Jyapu males and low in Gubhaju males. The intergroup differences were, however, statistically non-sign

ISSN:0001-5652    

DOI:10.1159/000152366

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

A genetic survey of some 700 Habbanite Jews from South-Arabia, who emigrated to Israel about 20 years ago, included a wide range of tests of red-cell antigens, serum groups, red-cell enzymes and secretion of ABH antigens. Among the remarkable results are high frequencies of B and M red cell antigens and acid phosphatase B type. Their haptoglobin 1 and phosphoglucomutase 1 gene frequencies are among the lowest yet recorded. A negroid component is suggested by the presence of genes such as V, cDe, Fy (a-b-) and Jsa, whereas their red-cell enzyme frequencies show little resemblance to those of negroid populations.

ISSN:0001-5652    

DOI:10.1159/000152367

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Using serial dilutions in the sorting test the taste thresholds for phenylthiocarbamide (PTC) were determined in Lapp populations in the region of Inari (Enare) in NE Finland and in unrelated Finns whose parents mainly came from the two northernmost Finnish counties, Lapland and Oulu (Uleåborg). A high frequency of non-tasters was noted among the highly related Skolt Lapp populations both at Sevettijärvi and Nellim, 28.3 and 29.7% respectively. The frequency of non-tasters among the Nellim Fisher Lapps was low, 10.5%, which is in good agreement with earlier measurements of taste sensitivity to PTC among Lapps.The frequency of non-tasters among the Finns was 22.1%. The frequency of PTC non-tasters among the Finns in North Finland seems to be lower than the figures reported by other authors for the Finns in South Finland. In all the populations studied a higher frequency of non-tasters and a lower average taste sensitivity for PTC were observed among males than among females. The Skolt males showed a marked reduction of the PTC taste sensitivity with ag

ISSN:0001-5652    

DOI:10.1159/000152368

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Three new variants in the C 3 system were discovered by high voltage electrophoresis in agarose gel. All 3 protein bands migrate slower than the most common allele product, the S band. The bands have, in order of decreasing electro-phoretic mobility, been named So.4, So.8, and So.9, respectively. The present studies indicate that at least So.4 and So.8 are genetically determined. The C 3 concentration of 4 adult sera containing the new variants were found to be normal.

ISSN:0001-5652    

DOI:10.1159/000152369

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Phosphoglucomutase phenotypes 8 1 and 8–2 have been found in members of a Jewish family in Israel. The PGMX8 allele stemmed from the father of the propositus, a non-Ashkenazi Jew from Morocco (PGM phenotype 8–1). The mother of the propositus (phenotype 2–2) was born in T

ISSN:0001-5652    

DOI:10.1159/000152370

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Palm prints of 166 Peruvian Cashinahua Indians from 3 villages were analysed for main line terminations and palmar patterns. Bilateral differences but no sex differences were observed with regard to main line terminations. Patterns in thenar/first and interdigitallV areas show bilateral variation, but none shows sex differences. The Cashinahua differ from other Amerindian groups in palmar patterns, but are similar to the Pewenche Indians of Chili with regard to the main line index. Considerable intervillage variation exists which may be explained in terms of micro-evolutionary processes acting on a small, isolated population.

ISSN:0001-5652    

DOI:10.1159/000152371

出版商:S. Karger AG    

年代:1970

数据来源: Karger