摘要:

Differential mortality as a function of birth weight was studied in Japan in the years 1969, 1974 and 1984. During the 15-year interval of observation a progressive equalization of mortality in the birth weight classes near the mean was found both for perinatal mortality as a whole and for its two components, stillbirth and mortality within the 1st week of life. The relaxation of selection on this metric trait is confirmed by the analysis of the variation over time of intensity of selection. A comparison of the Japanese population with other populations so far studied is also presented.

ISSN:0001-5652    

DOI:10.1159/000153773

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Using a simple and rapid one-dimensional isoelectric focusing technique followed by immunoblotting, we have detected genetic polymorphism of human apolipoprotein C-II (APO C-II) in normal unfractionated plasma samples of individuals of black ancestry. Two common autosomal codominantly expressed alleles, designated APO C-1I*1 and APO C-II*2, at the APO C-II structural locus have been observed with frequencies of 0.975 and 0.025 in US blacks and 0.943 and 0.049 in Nigerian blacks. In addition, the gene product of a rare allele designated APO C-II*3 was observed in a single Nigerian black. Apart from a single example of an APO C-II 2–1 phenotype in plasma samples from 187 whites, which was electrophoretically identical to the 2–1 phenotype observed in blacks, it appears that APO C-II*2 is a unique black marker of potential importance in anthropogenetic and atherosclerosis stud

ISSN:0001-5652    

DOI:10.1159/000153774

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Haptoglobin and transferrin (TF) types were determined for 134 patients with leukaemia of the four most common types: acute lymphocytic (ALL), chronic lymphocytic (CLL), acute myelocytic (AML) and chronic myelocytic leukaemia (CML). The phenotype HPl was found to have an increased incidence in the total patient group due to an increased incidence in those with AML, ALL and CML compared with controls, but not in those with CLL. Although tests of association applied to each of the samples of the four common types of leukaemia produced no significant χ2 values, they did indicate that the relative incidence (RI) was just under 2 for the groupings of the acute forms ALL and AML, the myelocytic forms AML and CML and for the combination of ALL, AML and CML, respectively. All these associations were statistically significant (p < 0.05). Analysis of TF subtypes and leukaemia indicated a significantly increased frequency of TF C1C1 among leukaemia patients compared with controls (p < 0.005). Analysis of the samples of each of the four common types suggested that while the RI was raised in all but ALL patients, the association was significant only in AML patients (p < 0.05). However, when the two myelocytic types were combined the RI was 2.3 and the association was highly significant (p < 0.005). No such association could be detected in the lymphocytic forms

ISSN:0001-5652    

DOI:10.1159/000153775

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Three Italian populations were examined for a multiple restriction fragment length polymorphism tightly linked to the human somatostatin gene. No difference was observed between the three samples. The haplotype frequencies in Italy were found to be: SST ESBS = 0.836, SST ESBF = 0.072, SST EFBS = 0.091 and SST EFBF = 0.001.

ISSN:0001-5652    

DOI:10.1159/000153776

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Starting from a chromosome-specific DNA library, we have isolated a human chromosome-specific satellite DNA sequence. This sequence of 635 base pairs (bp) consists of 3.7 alpha DNA monomers of 170–171 bp. Under high stringency it hybridizes to the centromere of chromosome 3 in a region composed of 2,750 bp tandem repeats characterized by the regular spacing of Hind III and TaqI restriction enzyme recognition sites. It has diverged and undergone amplification after the human speciation. The amplification allows an easy monitoring of the chromosome 3 centromere by in situ hybridization with a nonradioactive prob

ISSN:0001-5652    

DOI:10.1159/000153777

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Frequencies of the 6-phosphogluconate dehydrogenase (6-PGD) genes were studied in a series of 314 Finns from northern Finland and in a material of 4,348 conscripts and blood donors from the counties of Norrbotten and Västerbotten in northern Sweden. The Swedish individuals were distributed into 23 subpopulations according to place of birth. The frequency of the PGDC gene was comparatively high in Finns (5.3%) and showed significant variations between subpopulations (from 5.3 to 0.0%). The frequency of the PGDC gene showed a cline, with a decreasing gene frequency in the north-south direction. This geographical pattern could be explained in terms of Lappish and Finnish influence

ISSN:0001-5652    

DOI:10.1159/000153779

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A French population was investigated for genetic polymorphism of α2HS-glycoprotein (A2HS; nomenclature according to Human Gene Mapping 7, Los Angeles, 1983) using isoelectric focusing and immunoblotting. Three variants were observed together with two common alleles A2HS*1 and A2HS*2, whose frequencies were significantly different from the data in Canadians and Egyptians. An anodal variant to A2HS 1 was identical to a variant with two different nomenclatures reported by three different groups, indicating that there is a confusion in the A2HS nomenclature. The others were new variants with cathodal isoelectric points to A2HS 2 in the native state

ISSN:0001-5652    

DOI:10.1159/000153780

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The distribution of phenotypes and gene frequencies of the group-specific component (Gc) and C3 complement were studied in Central Sardinian sample. The gene frequencies were: Gc1 = 0.733; C3F = 0.237.

ISSN:0001-5652    

DOI:10.1159/000153781

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Haptoglobin groups were determined in 182 patients with primary ovarian carcinoma. Previously reported associations could not be confirmed. A significant excess of HP2–1 was observed among patients with a family history of cance

ISSN:0001-5652    

DOI:10.1159/000153782

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

By isoelectric fucusing, Gc and PGM subtypes were examined in a sample of over 450 Greeks from Thessaloniki and surrounding areas. The gene frequencies are compared with those from other Greek and European samples.

ISSN:0001-5652    

DOI:10.1159/000153783

出版商:S. Karger AG    

年代:1988

数据来源: Karger