摘要:

Four restriction fragment length polymorphisms, revealed by cloned arbitrary X chromosome segments (L1.28, RC8, pD2, 754) were studied in samples (50 individuals each) of a German and a Turkish population. All previously reported alleles of these polymorphisms were found in both populations, except the infrequent RC8 allele B3 (3.0 kb fragment), which was absent in both groups. The observed minor alleles were found to be rarer in the German series than in the Turkish group, but there was no conclusive evidence of essentially different allele frequencies in either population. However, the frequencies of the RC8 allele B2 (5.3 kb fragment) were differing at the 5% significance level. The allele frequencies of the four polymorphisms are presented and compared with those reported from other European regions.

ISSN:0001-5652    

DOI:10.1159/000153729

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

ABO blood group data from about 78,000 conscripts born 1900–1935 in Southeast Sweden have been analyzed for regional differentiation using a hierarchial subdivison of the area. Heterogeneity was present at all levels of division. Gene diversity among subpopulations has been compared to a corresponding estimate performed on data from the county of Västerbotten in northern Swed

ISSN:0001-5652    

DOI:10.1159/000153730

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

2,000 male individuals randomly selected from three different areas in The Netherlands were phenotyped for apolipoprotein E. The apolipoprotein E gene frequencies and phenotype distribution did not differ significantly from that of previously studied populations, with one exception: the ε4 frequency was significantly lower than that in the Finnish population.

ISSN:0001-5652    

DOI:10.1159/000153731

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Blood samples from 257 hypertensive patients and 180 normotensive controls were analysed for their association with haptoglobin levels and phenotypes. Compared to controls, patients with Hp 2–2 phenotype showed a significantly increased risk for essential hypertension (p < 0.001) and hypertension associated with ischaemic heart disease (p < 0.05). There was a significant decrease in the mean levels of serum haptoglobins in hypertension as compared to controls, suggesting the possibility for intravascular haemolysis due to vascular damage leading to further complication

ISSN:0001-5652    

DOI:10.1159/000153732

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

In 109 subjects from 50 families without major inherited disorders, sweat pore count showed the anticipated reduction with age but also unexpected systematic differences between sides and between fingers. After adjustment for age and sex, significant genetic variation was found for sweat pore count, hair density and tooth size. The three traits were not phenotypically correlated but there was a significant negative genetic correlation between hair density and sweat pore count. The findings suggest that the sames genes influence these two traits in opposite directions and that genetic and environmental influences may act on them through different physiological mechanisms.

ISSN:0001-5652    

DOI:10.1159/000153733

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Serum protein markers (Hp, Pi, Bf, C4, C3 and Tf) were studied in 71 patients with ankylosing spondylitis. Significant associations were found with the α1-antitrypsin (Pi) type MZ and with the BfS and C3FS types in female patients

ISSN:0001-5652    

DOI:10.1159/000153734

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

We compared family distances of homozygotes and heterozygotes for HLA-A and -B. When matched on number of inhabitants per birthplace, no significant differences were found. However, when homozygotes were compared with heterozygotes from larger birthplaces, homozygotes showed significantly smaller family distances in the grandparental generation. We suggest that matching for population size of birthplace and the choice of the geographic study area are important factors in studies of family distances.

ISSN:0001-5652    

DOI:10.1159/000153735

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A series of 171 blacks from Trinidad, West Indies, was studied with respect to haemoglobin types, serum protein systems (Tf and Gc subtypes) and red cell enzyme types (AcPh, 6-PGD, AK, EsD, GLO and PGM1). The average Caucasian admixture was estimated at 25 %.

ISSN:0001-5652    

DOI:10.1159/000153736

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Three new alleles of human red cell acid phosphatase (ACP1) have been identified by comparison with previously reported variants using three different electrophoretic techniques. Family data are available on all the variants and show genetic transmission of the rare alleles ACP1*N, ACP1*P and ACP1*S. Further evidence of a rare allele demonstrating reversed ‘A’ activity is also described. The report documents the need to use several electrophoretic techniques to characterize new or rare varia

ISSN:0001-5652    

DOI:10.1159/000153737

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Haptoglobin (Hp) subtypes have been determined in the Japanese population by polyacrylamide gel isoelectric focusing followed by immunoblotting and by two-dimensional polyacrylamide gel electrophoresis. In the present study, neuraminidase-treated plasma samples were used for subtyping of Hp, without prior purification. These samples were obtained from 372 unrelated healthy donors. Allelic frequencies were: Hp*1F = 0.0014; Hp*1S = 0.2688; Hp*2FF = 0.0000; Hp*2FS = 0.7284, and Hp*2SS = 0.0014. The phenotypic distribution was in good accordance with the Hardy-Weinberg equilibrium.

ISSN:0001-5652    

DOI:10.1159/000153738

出版商:S. Karger AG    

年代:1987

数据来源: Karger