摘要:

G1m(a) and G1m(x) allotype distribution is analyzed in a sample population from Calabria (South Italy). The paper presents data showing an unusually high frequency of the G1m(x) marker. Furthermore, results concerning a rare Gm(x) phenotype are also shown. The findings suggest the important contribution yielded to the Calabrian genetic pool by the Albanian population that immigrated to this region in the 15th century.

ISSN:0001-5652    

DOI:10.1159/000153378

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Two recent methods for detecting major genes under continuous variation are investigated, by analysis of both simulated and real data. The major gene index of Karlin is shown to be sensitive to the distribution of gene effects in such a way that it may not detect major genes in certain cases. The intrafamily correlations of Matthysse et al. are shown to yield values difficult to reconcile with established patterns of inheritance for certain traits.

ISSN:0001-5652    

DOI:10.1159/000153379

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In an anthropological investigation of 114 Bengalee families of the Sodepur industrial suburb of Calcutta, the average haemoglobin level is found to be significantly lower in males with A1 blood group than those with other blood groups, and this is more marked in young age. A depression of the haemoglobin level is also apparent in women of reproductive age who have blood group O, conforming to the suggestion of greater bleeding tendencies in individuals with·blood group than in others.

ISSN:0001-5652    

DOI:10.1159/000153380

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Human phosphoglucomutase activity has been determined in red blood cells obtained from 348 unrelated subjects. The mean activities attributed to the four common PGM1 alleles, expressed as micromoles of G6P produced per gram of Hb per hour were 53 for PGMa13, 60 for PGMa11, 61 for PGMa14 and 72 for PGMa12. The relative amount of variation associated with the electrophoretic polymorphism was estimated as 24%.

ISSN:0001-5652    

DOI:10.1159/000153381

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Commingling in the distributions of five lipids and lipoproteins was investigated in a sample of 567 Caucasians. Significant commingling was found for high density lipoprotein, low density lipoprotein, and very low density lipoprotein, but not for cholesterol and triglyceride. The differences between the present results and those reported earlier on a sample of Japanese-Americans are described and found to be partly attributable to differences in the sample sizes of the two studies.

ISSN:0001-5652    

DOI:10.1159/000153382

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The incidence of hepatitis B surface antigen (HBs Ag, Australia antigen) has been determined in three communities residing in an endemic malarial region in Western Maharashtra. A high incidence (5.92%) is found in the Marathas, a socially well-placed community, as compared to Nava-Buddhas (2.62%) and scheduled castes (1.63%) which are socially low-placed communities. A higher incidence (8.91 %) among the Maratha females is a surprising observation as the males have been shown to be predominant among HBs Ag carriers in most world populations. A positive association of HBs Ag and the anthropometric traits, skinfold thickness of biceps and triceps, has been observed in the present study. The results demonstrate that other factor(s) (e.g. immunological) besides malarial infection may be involved in the maintenance of a high HBs Ag frequency in Western Maharashtra.

ISSN:0001-5652    

DOI:10.1159/000153383

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Transferrin subtypes have been determined by isoelectric focussing of sera from 3,787 individuals in selected populations in the Asian, Pacific and Australian area. TfC1and TfC2were present in all populations studied. TfC3 was found to be polymorphic in a few populations only. The highest frequency of TfC2was found in the Soliga (34%), an Indian tribal population, and the lowest TfC2 safrequency was in Australian Aborigines (3%). In Pacific island populations TfC2was found to be variable between 4 and 22%. A new subtype allele, TfC6, was observed at polymorphic frequency in Australian Aborigines.

ISSN:0001-5652    

DOI:10.1159/000153384

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A test of linkage that is exact even in small samples is developed for multiple case families, together with large-sample theory for estimation and supplementary tests. Hemochromatosis, insulin-dependent diabetes, and celiac disease are compatible with an intermediate model biased toward recessivity on the penetrance scale, whereas multiple sclerosis favors dominance and unlinked modifiers. Alternatives to the model are complex, and comparison of affected sib pairs with larger sets of relatives provides no critical evidence of epistasis. Problems of sampling and inference are discussed.

ISSN:0001-5652    

DOI:10.1159/000153385

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Haemolysate samples from two caste populations, namely Brahmin and Kamma from coastal Andhra Pradesh, India, were typed for acid phosphatase by using starch gel electrophoresis with the discontinuous buffer system. The sample includes 225 Brahmins and 221 Kammas. Only A, B and AB phenotypes were observed and a statistically significant difference was found between the two caste groups in their acid phosphatase distribution. An association of higher B gene frequency with non-vegetarian diet is also suggested.

ISSN:0001-5652    

DOI:10.1159/000153386

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The hypothesis of linkage between HLA and a disease susceptibility (DS) locus (or loci) for type 1 diabetes was tested. HLA segregation was random among 57 non-diabetic sibs but not among 39 diabetic sibs, suggesting that susceptibility to type 1 diabetes may be due to an HLA-linked gene(s). The data did not fit a genetic model involving either a single recessive or dominant gene. The excess of HLA-identical diabetic sibs and the reduced number who were HLA-discordant compared to expected numbers indicated that factors from both paternal and maternal haplotypes were necessary for DS. In 1 of the 3 families with a diabetic parent and more than one diabetic sib, the diabetic sibs inherited different haplotypes from the affected parent, suggesting that either of these haplotypes conferred DS. HLAB 8, B 18 and B 40 were increased in frequency among 97 unrelated type 1 diabetics compared with 238 controls, especially among those with onset age less than 10 years. This early onset group may represent a subtype of type 1 diabetes.

ISSN:0001-5652    

DOI:10.1159/000153387

出版商:S. Karger AG    

年代:1983

数据来源: Karger