摘要:

Protein polymorphism is studied in more than 900 serum samples during different investigations conducted in a Bi Aka Pygmy group. The Gc, Tf and α1-antitrypsin subtype polymorphisms were determined after isoelectric focusing while the haptoglobin α and α2-peptides were studied on PAGE. A high frequency of the Hp2 gene is noted while Hp1F and Hp1S gene frequencies are similar. According to the Gc1S and Gc2 gene frequencies this group falls within the cluster of the melanoderm populations such as the Sara, Bantu and Peulhs. The two subtypes TfC1 and TfC2 are present in this sample. TfC3 is absent. The TfD1 variant frequency is one of the highest observed in African groups. The α1-antitrypsin polymorphism corresponds to the presence of the three PiM subtypes. No other variants are observed, neither PiS nor PiZ. For the first time a highly significant association is described between the TfD1 and Gc1A1 (GcAb) genes. Family pedigrees do not permit the ascertainment of the linkage between the two l

ISSN:0001-5652    

DOI:10.1159/000153195

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Caucasian and Afro-American schoolchildren participating in a community-based cardiovascular screening program in Bogalusa, Louisiana are characterized with respect to phenotypic and allelic frequencies at 10 enzymatic and 3 nonenzymatic polymorphic loci. Biracial gene frequencies in Bogalusa are compared with those reported for other populations of similar ethnic composition. Intra- and interracial genetic distances within and between the racial subpopulations of Bogalusa and Seattle, Washington are compared. While the comparisons do not support the concept that northern, urban blacks have more Caucasian admixture than blacks residing in the rural South, they do suggest microdifferentiation of the two white populations.

ISSN:0001-5652    

DOI:10.1159/000153196

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Transferrin subtypings have been performed on three population samples originating from Himachal Pradesh, North India (Pangwala, Gaddi-Bharmour valley, Gaddi-Kangra district) and on three samples from Andhra Pradesh, South India (Koya, Konda Kammara, Lambadi). Among these six populations, marked differences in the distribution of Tf phenotype and allele frequencies are present. All Indian samples differ clearly from the hitherto reported TfC1 and TfC2 allele frequencies. In one of our Indian samples, the Pangwala, the most likely existence of a new Tf subtype variant (Tf Pangwala) could be demonstrated.

ISSN:0001-5652    

DOI:10.1159/000153197

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Leukocyte lysates obtained from blood specimens of individuals from Central and Western Pyrenean groups (Barèges and Basques) and from the population of Toulouse city have been typed for PGMa1 isozymes using isoelectric focusing (pH range: 3–9.5) in polyacrylamide gels. The determination of usual PGM1 phenotypes was simultaneously performed on red cells by starch gel electrophoresis. Significant differences were found between the three communities. In Barèges samples only 6 of the 10 phenotypes known at PGMa1 locus have been observed. In the same group, 36 mating types were studied in distinct families. The segregation on the phenotypes is in agreement with the codominant inheritance of the alleles. In Basques the gene frequencies showed intermediate values between Toulouse and Barèges. PGMa21 reaches a higher frequency in the latter community (0.306). In the Toulouse population sample the results are comparable with those previously published in western Europ

ISSN:0001-5652    

DOI:10.1159/000153198

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The aim of this work is to examine the validity of several χ2 criteria, when used to test the fit of genotypic frequencies to the Hardy-Weinberg law. The exact type I error probabilities were compared to the nominal significance levels for two genetic models. The Pearson’s χ2 test usually provided the best approximations. This test was found to be remarkably robust, even in situations involving very small expected frequenc

ISSN:0001-5652    

DOI:10.1159/000153199

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A random sample of more than 500 subjects collected in the district of I’Aquila (Italy) has been studied for the following genetic markers: ADA, EsD, G-6-PD, 6-PGD, SOD-A, Hp, C3. The gene frequencies of all the systems examined were similar to those observed in Rome. Rare variants have been found for 6-PGD, C3 and SOD-A. The last one showed an electrophoretic pattern different from the only other variant so far observed in the Italian populatio

ISSN:0001-5652    

DOI:10.1159/000153200

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The relative viability of heterozygotes is investigated for two groups of loci. Group A includes serum antigen systems and polymorphisms demonstrated after electrophoresis by general stains or histochemical methods. Group B includes dominantly inherited traits and enzyme deficiencies. The two types of offspring of the mating of a heterozygote and a homozygote are expected to occur in the segregation ratio of 1:1. For loci where there is complete penetrance and complete ascertainment of sibs, significant deviations from this ratio can be ascribed to selection at the locus or at a locus in linkage disequilibrium. The complication of linkage disequilibrium is eliminated by analysis of a large number of traits and the tentative conclusion is reached that there is a prevalence of loci with heterozygote advantage. The estimates of viability differentials would be improved by the analysis of more pedrigrees from a disparate sample of traits.

ISSN:0001-5652    

DOI:10.1159/000153201

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Sera from 150 individuals from Southern Italy were screened for α1-antitrypsin (α1AT) types. The frequencies of the Pi alleles were compared with those found in Northern Italy and Central/Southern Italy. The PiS frequency in our sample (0.02667) was lower than that found in Central/Southern Italy (0.0670) but matched with the result obtained in Northern Italy (0.0297). The gene frequencies for subtypes of M in Northern and Southern Italy are presente

ISSN:0001-5652    

DOI:10.1159/000153202

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The C3 phenotypes were examined in 391 pregnant women classified according to the level of ‘immune’, ‘natural’ and ‘irregular’ antibodytitres. No significant association between the C3 types and antibody levels was found. The sera were also typed for C3 with a non-barb

ISSN:0001-5652    

DOI:10.1159/000153203

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Gene frequencies of PGM1 phenotypes as obtained by isoelectric focusing on polyacrylamide gel in the pH range from 4 to 8 were determined in 501 samples of Swiss blood donors. Results were in good agreement with the expected distribution according to the Hardy-Weinberg law. Frequencies were PGM1a1 = 0.6278, PGM1a2 = 0.1936, PGM1a3 = 0.1297, PGM1a4 = 0.0489. Comparison with other data of the white population showed no significant differences. Isoelectric points of regular and rare gene products were determined. Application of the method in routine paternity testing is discussed.

ISSN:0001-5652    

DOI:10.1159/000153204

出版商:S. Karger AG    

年代:1981

数据来源: Karger