摘要:

The distributions of the phenotype and gene frequencies of nine polymorphic systems in human parotid and whole saliva were studied in the Japanese population of the eastern part of Japan and compared with those of populations in other areas of Japan and other ethnic groups. The gene frequencies were: Pa+ = 0.214; Pb1 = 1.000; Pr1 = 0.753; Db+ = 0.035; PmF+ = 0.394; Ph+ = 0.028; PIF+ = 0.733; Amy1v = 0.011, and s-AcpA = 0.217.

ISSN:0001-5652    

DOI:10.1159/000153836

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Recombination between the marker locus and disease locus introduces a risk of diagnostic error that must be considered when performing indirect diagnosis of monogenic disorders by means of a linked DNA polymorphism or another marker. A method is presented which improves the hitherto used estimates of the magnitude of this error. Principally, it makes use of the fact that recombination between marker and disease locus needs not necessarily increase the error rate; if it occurs twice or several times during the diagnostic process, the final diagnosis may be correct.

ISSN:0001-5652    

DOI:10.1159/000153837

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The genetic polymorphisms of nine biochemical genetic markers were investigated in four populations (Turks, Kurds, Tehranis and Kermanis) living in the north-east and south-east regions of Iran. Only one of the nine loci studied (acid phosphatase) showed significant gene frequency differences and for the C3 system the F allele frequencies in these populations were the lowest ever reported from Iran.

ISSN:0001-5652    

DOI:10.1159/000153838

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

C8 inheritance patterns in 364 mother-child pairs formed the basis for evaluation of the existence of silent alleles (null alleles) in the genes determining the two known polymorphic C8 systems. While evidence for such alleles was not found in C8A (α-γ complex), two observations of null allele segregation in C8B (β chain) indicate a C8BQ*0 allele frequency of about 0.07. Two population samples comprising 150 Lappish and 1,264 non-Lappish Norwegians were examined for phenotype distributions in C8A and C8B. The phenotype distributions were mainly in accordance with the expected Hardy-Weinberg distribution. The results for C8A indicated simple, codominant inheritance of two frequent and several rare alleles. Allele frequencies were similar in the two populations. The C8A B gene frequency in Norwegians was significantly lower than that in FRG and higher than that in Negroes. C8B allele frequencies were also calculated from gene counts in the population material, but with due corrections for the C8BQ*0 frequency observed in the mother-child materi

ISSN:0001-5652    

DOI:10.1159/000153839

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

HLA-A, B and C phenotypes and gene frequencies of Chinese living in Taiwan are presented. Cw1 and Cw3 were frequently found to segregate together on the same haplotype.

ISSN:0001-5652    

DOI:10.1159/000153840

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Five hundred and eighty-five serum samples from six populations in Colombia (Baranoa, Choco, Uitoto Indians, Subachoque, Pasto and Urban Bogotan) were investigated for four genetic markers. For the HP, C3 and BF systems but not for TF there is a wide range of gene frequency variation and these differences are compared with those in the few previous studies.

ISSN:0001-5652    

DOI:10.1159/000153841

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Genetic drift and natural selection were analyzed in a genetically isolated Zapotec-speaking community in the Valley of Oaxaca, southern Mexico. Moderately intense genetic drift and selection potentials were found. Potential for drift was related to (1) the small effective size of the population, and (2) the exceptionally low number of migrants into the population. Potential for selection was due to (1) an unusually high variance in fertility, and (2) a high contribution of prereproductive mortality. Significant potential for genetic evolution was found due to genetic drift and natural selection.

ISSN:0001-5652    

DOI:10.1159/000153842

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Family linkage studies were used to detect two linkage relationships on human chromosome 1. The B subunit of coagulation factor XIII showed significant linkage to renin with a maximum lod score of 5.071 at a distance of 10 cM. Significant linkage was also shown between the Duffy blood group and α-spectrin with linkage results giving a combined lod score of 3.194 at 5 cM

ISSN:0001-5652    

DOI:10.1159/000153843

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Autopsy liver samples from 244 Chinese, 119 Malays and 136 Indians were screened for glutamate-pyruvate transaminase (GPT) subtypes by starch-gel electrophoresis and isoelectric focusing at pH 5–7. Altogether, ten phenotypes controlled by four alleles (GPT1, GPT2A, GPT2B and GPT3) were identified. There was no significant difference in the frequency of GPT alleles between the ethnic groups. The distribution of GPT types was in agreement with the Hardy-Weinberg equilibrium in all the ethnic group

ISSN:0001-5652    

DOI:10.1159/000153844

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Baseline data are presented on phenotype and gene frequency distributions of nine red-cell enyzme systems (ADA, AK, EsD, GLO I, PGM1 AP, GPI, PGM2, SOD) in the Sunni Muslims of Kashmir valley in the northernmost Indian border state of Jammu and Kashmir.

ISSN:0001-5652    

DOI:10.1159/000153845

出版商:S. Karger AG    

年代:1989

数据来源: Karger