摘要:

Six enzyme polymorphisms have been studied in European and Asian populations, using kinship as an index of genetic differentiation. Four clusters of populations are apparent, corresponding to four geographical regions. The differences between such groups account for a large fraction of genetic diversity, while minor differences are apparent between populations belonging to the same continent or subcontinent. The kinship as bioassayed from three loci (GLO, ESD, 6-PGD) correlates significantly with space, showing an exponential decline with the increase of distance between populations.

ISSN:0001-5652    

DOI:10.1159/000153716

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A sample of 102 individuals from the Korkus tribe, an Australoid race inhabiting Central India, was studied for the distribution of haemoglobin and ten red cell enzyme types. Polymorphism was observed in G6P dehydrogenase, acid phosphatase, adenylate kinase and glyoxalase I types and in phosphoglucomutase subtypes. The lactate and malate dehydrogenases, glucose phosphate isomerase and superoxide dismutase systems were monomorphic. A single case of Hb AS was observed. The Korkus were found to have GdA+; lower frequencies of pa, AK2, GLO1and PGM2+ were observed in the Korkus in comparison to other related tribes and caste Hindus of the same region.

ISSN:0001-5652    

DOI:10.1159/000153717

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A number of parameters were evaluated in order to determine the level of isolation of a small Brazilian community existing in partial geographic isolation and thereby evaluate the random genetic drift potential in the population. On a theoretical basis, it is concluded that the probability of genetic drift is low but cannot be excluded. The relatively small proportion of migrants (26%), the limited individual mobility, as given by marital distance (29 ± 7 km), the mean migrational distance (46 ± 11 km), the small effective size (122), and the value of the product Neme (26) agree with the possibility of genetic drift in this population. The observed coefficient of inbreeding (0.00239) is lower than that expected (0.0066) for random mating, suggesting some pressures against consanguineous marriag

ISSN:0001-5652    

DOI:10.1159/000153718

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The present study is to determine the effects of centromeric heterochromatin on centromere separation. Amniotic cell cultures in which the centromeric heterochromatin of one chromosome was at least twice as large (qh+) as the heterochromatin (qh) in the homologous chromosome were selected. Fifteen amniotic cell samples with 1qh+, 9qh+ or 16qh+ were studied. The size of the centromeric heterochromatin was directly correlated with the delay in centromere separation. The chromosome with the smaller centromeric heterochromatin tended to show earlier centromere separation than the homologue with the larger heterochromatin. Our results suggest that the quantity of centromeric heterochromatin may influence the genetic control of centromere separation.

ISSN:0001-5652    

DOI:10.1159/000153719

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Frequencies of the α1-antitrypsin (Pi) alleles and haptoglobin phenotypes have been determined in a series of 264 North-German patients with bladder cancer. Compared to a healthy control population, we found a statistically significant decrease of Hp 2-2 phenotype in the patient series. A significant increase of the serum Pi Z allele, as previously shown for patient groups with certain other tumours, could also be confirmed for bladder cancer. Furthermore, a distinct association between a lowered M 3 allele and bladder carcinoma was observed

ISSN:0001-5652    

DOI:10.1159/000153720

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The sensitivity and specificity of isoelectric focusing (IEF) and immunoblotting have been combined for the routine typing of the plasma protein alpha-1 acid glycoprotein (Orosomucoid, ORM). Optimized conditions have been determined for a reliable classification of different ORM phenotypes. Phenotypic patterns of ORM in simple IEF gels correspond to those observed by other techniques. Addition of 6 Murea in a thin-layer IEF gel revealed additional, informative microheterogeneity in the ORM system, which cannot be detected in simple IEF gels. Applying the improved method, 239 White and 181 Black Americans have been screened to determine the distribution of ORM allele frequencies. Two common alleles, ORM*1 and ORM*2, have been observed and their frequencies are 0.5592 and 0.4408, and 0.6160 and 0.3840 in Whites and Blacks, respectively. Family studies confirm the genetic basis of this variation which is compatible with autosomal, codominant inheritance.

ISSN:0001-5652    

DOI:10.1159/000153721

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The results of a population survey on blood group distribution in Somalia, East Africa, are presented. Over 1,000 subjects were tested for most blood groups included in the survey. The sampling covered the whole country and was well in accordance with the population density as estimated by the recorded birth places of the subjects. Altogether, 46 blood group antigens were tested, partly common antigens within 11 of the major blood group systems, but also infrequent and very frequent antigens, some not tested before in Africa, were included. The results were compared with the available data for other related peoples and for populations from the same geographical area. The standard genetic distances were also applied in the comparison. The results suggest that only a minor component in the genetic constitution of the Somali population can be ascribed to Caucasian admixture. They are markedly in contrast with some earlier findings. During the survey we observed a previously unknown Rh gene complex occurring with a polymorphic frequency in Somalis.

ISSN:0001-5652    

DOI:10.1159/000153722

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Using restriction endonucleases Bam HI, Bg 1 II, Hpa I, Hind III and Xba I, the αααanti 3·7/ haplotype was studied in the Saudi population. This paper presents the frequency of the alpha gene haplotype αααanti 3·7/ in different regions of Saudi Arabia, where thalassaemia occurs at a high fr

ISSN:0001-5652    

DOI:10.1159/000153723

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

In previous investigations transferrin C2 has been found to be associated with spontaneous abortion and premature birth. In a study of newborn infants from northern Sweden, no significant correlation was found between birth weight and transferrin C2 of the infants. Thus transferrin C2 appears to be associated with reproductive disturbances and with premature birth, but not with birth weight in mature infants.

ISSN:0001-5652    

DOI:10.1159/000153724

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Human red cell delta-aminolevulinic acid dehydratase (ALADH; EC 4.2.1.24) polymorphism was studied in three population samples of the Basque Country. The frequency of the ALADH2 was around 0.08 and similar to that in other European countries.

ISSN:0001-5652    

DOI:10.1159/000153725

出版商:S. Karger AG    

年代:1987

数据来源: Karger