摘要:

Electrophoretically detected genetic polymorphism of human MHC class III genes, factor B (Bf) and complement C4A and C4B, was studied in the Finnish population. Bf alleles were determined in a panel of sera from 70 unrelated individuals. The common Bf alleles, Bf*S and Bf*F, had frequencies of 73% and 26%, respectively. Only in 1 individual was another allele, Bf*Fl, detected. The frequencies of the C4A and C4B alleles were based on studies of 254 unrelated individuals. In this panel, five different alleles were detected at the C4A locus and four at the C4B locus. At both loci an allele without a gene product, i.e. a ‘null’ allele, was observed with high frequency, 11 % for C4A ‘null’ and 17% for C4B ‘null’. The association of complotypes to HLA haplotypes was analyzed in 70 chromosomes. The most common combination, defined by class I and class III alleles, was HLA-B7-S31 (13%), followed by HLA-B35-F20 (8.4%) and HLA-B8-S03 (7.1%). Some HLA-B specificities, for example B15, B27 and B40, were associated with a variety of complotypes. The importance of complotyping in HLA genetics i

ISSN:0001-5652    

DOI:10.1159/000153642

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Blood genetic markers were investigated in a sample of 111 Bedouin and 412 non-Bedouin male Arabs of Jordan. The frequencies of the ABO alleles were similar in these two groups, with a relatively high frequency of the·gene (0.63; 0.61). The frequencies of Rh genes were slightly different in these two groups, with a higher Ro, and a lower r in the Bedouins. A sub-sample of a smaller size was investigated for the distribution of haptoglobin types, Tf subtypes and red-cell G6PD (glucose 6-phosphate dehydrogenase) phenotypes. There was no significant difference in any of the systems between the two populations. No haemoglobin variant was detected. The study confirms the Arab characteristics of Jordanians with a small degree of African admixture

ISSN:0001-5652    

DOI:10.1159/000153643

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The electrophoretic polymorphism of the PGP locus has been studied in about 1,700 Italians. The sample consisted of individuals from Viareggio (North-Central Italy), Rome (Central Italy) and Cagliari (Sardinia, Southern Italy). Comparison among the three groups showed a high degree of heterogeneity. The Sardinian sample was well differentiated from the other two concerning the frequencies of both the PGP3 and of PGP2 alleles. The frequency of the PGP1 allele varied from 0.900 (Viareggio) to 0.987 (Cagliari). The gene frequencies, together with those available for other European populations were plotted against the latitudes of the different localities sampled and fitted to a North-South cline.

ISSN:0001-5652    

DOI:10.1159/000153644

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

More than 800 blood samples from members of 13 tribal groups in the northwest of Australia have been tested for 18 enzyme systems controlled by 21 loci and for haemoglobin. Two novel alleles, PGM121 and ACPF1, are each restricted to a single tribal population, suggesting relatively recent mutations. Other alleles conform very broadly with their distributions in other Australian Aboriginal populations. In particular, PGM32 maintains its inland distribution whilst PGDE and PEP B6 continue to be restricted to the north of the continent. Comparisons between tribes show the Baada to be distinctive, with high values of PGM21, GPT2, CA42 and ESD2 as well as having the novel allele ACPF1.

ISSN:0001-5652    

DOI:10.1159/000153645

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The group-specific component (Gc) subtypes were determined in 575 adult Finns by immunoblotting after isoelectric focusing in agarose gel. The gene frequencies were Gc1s= 0.661, Gc1F= 0.139 and Gc2=0.200. This material included one rare allele, a more acidically focusing Gc 2 (named Gc 2A18). The phenotypes of 200 mother-child pairs studied were in accordance with the three-allelic mode of inheritance. An apparent mother-child incompatibility observed during routine paternity testing is reported.

ISSN:0001-5652    

DOI:10.1159/000153646

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The inbreeding coefficients (F) were estimated according to marital distance between birthplaces and the opportunity of encounter. As for marital distance, the F-value was the highest for the shortest distance (0.00252), whereas the F-values were similar in the other distance classes (0.00072–0.00097). As for opportunities of encounter, the F-value was 30–37 times higher in the group for friendship from the time of childhood (0.00986) than in those for school, workplace and social gatherings (0.00033) and for chance meetings (0.000

ISSN:0001-5652    

DOI:10.1159/000153647

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Blood from 304 newborn infants of Melbourne, Australia, was examined for 9 polymorphic systems (red cell antigens ABO, MNSs, Rh, Kell, Duffy and Kidd, the red cell enzyme ESD and serum proteins GC and TF) in order to investigate the evolution of the Melbourne gene pool since 1975. Immigration patterns have changed considerably over the past 10 years, especially with an increase in refugees from South-East Asia. Three ethnic categories were identified on the basis of surnames; British Isles, Europe and Middle East, and South-East Asia, with the respective allele/haplotype frequencies of these groups being similar to those found in the source regions. Analysis by an R-matrix indicated that the Asians form a very distinctive subpopulation, but that their influence is minimal to date.

ISSN:0001-5652    

DOI:10.1159/000153648

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Segregation analysis of 99 sibships in 2 samples from Venezuela and Japan indicates that a torus palatinus is inherited in simple dominant fashion. The gene shows variable expressivity and penetrance close to 85%, without significant heterogeneity between the populations considered. No evidence of sporadic cases has been found.

ISSN:0001-5652    

DOI:10.1159/000153649

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A father-child incompatibility only in the Gc system was detected in a paternity case tested at our laboratory. Quantitative determination revealed that the Gc level in the two individuals was less than 50% of the normal mean value. Evaluation of the probability calculation for the putative father using all other markers showed that he was the biological father with a very high probability. Thus it was concluded that a silent allele Gc*QO was transmitted from the father to the child.

ISSN:0001-5652    

DOI:10.1159/000153650

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The C3 and Bf polymorphisms were studied in 1,000 unrelated Italians. The gene frequencies were calculated and compared with other districts of Italy.

ISSN:0001-5652    

DOI:10.1159/000153651

出版商:S. Karger AG    

年代:1986

数据来源: Karger