摘要:

In 153 male schizophrenic probands born in 1881–1900 the age range of onset ran from 9 to 77 years, the mean and standard deviation were 35.6^12.6 years. By securing probands from a sufficiently distant birth period one avoids the bias caused by dilution of the material with index patients with early manifestation, who get a disproportionally high chance of ascertainment by sequential admission sampling. By calendar year of birth 748 full sibs of probands ranged from 1865 to 1919, with an age corrected incidence of schizophrenia with hospital care of 11.6%. A mean number of 3 sibs per proband were still alive when 50 years old. The birth period approach reduced losses of sib material through curtailing the observation period to less than 0.2%. Together with varieties within sibships the extended risk period for schizophrenia adduces suggestive evidence against autosomal recessive inheritance as a major cause of this psychosi

ISSN:0001-5652    

DOI:10.1159/000152316

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Data obtained in 29 villages of the Leiria region, Portugal, as regards precocious mortality (abortions, miscarriages, stillbirths and infant-juvenile mortality) and consanguineous marriages, using 3 different types of control (neighbours, cousins and sibs), revealed a load of about 2 lethal equivalents per gamete (lethons). The series with sib control led to an estimate of 2.31 ± 0.42 lethons with all the kinds of consanguineous marriages and of 1.48 ± 0.33 with only first cousin

ISSN:0001-5652    

DOI:10.1159/000152317

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

In a female with mental retardation, degenerative features, heart defect and congenital luxation of the left hip joint there was found an abnormal karyotype, revealing an acrocentric chromosome no. 2 and a metacentric chromosome in the C-group. The morphological patterns of the chromosomes and the phenotypical abnormalities in the patient lead to the assumption that the two chromosomal aberrations arose separately, rather than that it was a case of reciprocal translocation.

ISSN:0001-5652    

DOI:10.1159/000152318

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Cytogenetic investigation of a phenotypically normal female with male social attitudes revealed that while most of the cells had a karyotype of 46 XX, a minority were 47 XXY. The origin of the mosaicism has not been established.

ISSN:0001-5652    

DOI:10.1159/000152319

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The rare phenotype Gm(a–x+b + ) was studied in 3 Danish families. The Gm type determinations comprised the factors Gm(z), (a), (x), (f), (g), (b°), (b1), and (b3). In family No. 1 and 3 and in some members of family No. 2 also the Gm(n), (s), (t), (c) and (b4) types were established. The gene complex giving rise to the phenotype Gm(a–x+) probably is GmP Gmí, c. The origin of this gene complex is discussed, and its frequency in the Danish population is esti

ISSN:0001-5652    

DOI:10.1159/000152320

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The phenotypes of the Gm, Inv, and ISf system were studied in 106 subjects of Danish origin. The frequencies of the factors Gm [(1, 2, 4, 5, 8, 10, 11, 14, 17, and 21)], Inv [(1 and 2)], and ISf (1) are given. Rare phenotypes Gm (1, 17, –21), Gm (–1, –17, 21), and Gm (–1, 17, –21) were observed. Two reagents considered as anti-Gm (21) appear in this population to recognize two different spec

ISSN:0001-5652    

DOI:10.1159/000152321

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Data on four polymorphic serum proteins: group specific, haptoglobin, albumin and transferrin, are reported for the Zuni and Papago Indian tribes. The data were collected using a rapid acrylamide gel electrophoresis method. The relationship between tribes of the southwestern part of North America suggested by these data are discussed briefly.

ISSN:0001-5652    

DOI:10.1159/000152322

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0001-5652    

DOI:10.1159/000152323

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0001-5652    

DOI:10.1159/000152324

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Studies on PGMj and PGM3 isozymes in leucocytes from 110 matings with 383 children and 138 mother-child combinations support the hypothesis that these characters are determined by codominant alleles at two separate loci. The two characters were found to be fully developed in leucocytes at birth. The frequency in Denmark of the least common allele at the two loci is 0.19 for PGMJ and 0.25 for PGM∣. The two loci PGM]^ and PGM3 showed no indication of linkage or association and may therefore be regarded as independent markers. A pedigree of a family with the rare PGM* allele is presente

ISSN:0001-5652    

DOI:10.1159/000152325

出版商:S. Karger AG    

年代:1970

数据来源: Karger