摘要:

Haptoglobin and transferrin types were studied in schizophrenic patients and controls. In the haptoglobin system a significant departure from the Hardy-Wein-berg equilibrium with an excess of heterozygotes was found among the patients (p& < 0.01). The distribution of haptoglobin types in the schizophrenic patients was significantly different from that in the controls. The distribution of transferrin types showed a good agreement with the Hardy-Weinberg equilibrium. There was no significant difference between patients and controls with respect to transferrin types.

ISSN:0001-5652    

DOI:10.1159/000153519

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

By high-voltage agarose gel electrophoresis, seven phenotypes of C3 were found in Japanese. The allele frequencies for C3*S, C3*S025, C3*S02, C3*F, C3*F06, C3*F065, and C3*F08 were 0.9943, 0.0003, 0.0003, 0.0006, 0.0003, 0.0021, and 0.0021, respectively. CH50, C3/C3c protein concentrations, and C3 hemolytic activities in fresh sera with variant C3 phenotypes were within the normal ranges.

ISSN:0001-5652    

DOI:10.1159/000153520

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The utility of incompletely linked, selectively neutral, multiallelic markers for tracing the transmission of associated genes is examined theoretically for all genetic counseling situations in which the diagnosis of deleterious progeny is in question. The analysis focuses on the fraction of progeny from each two locus mating which can be diagnosed with minimal accuracy A solely on the basis of the marker alleles transmitted, as a function of A, the recombination fraction between the loci, and the gametic frequency distribution in the population. Together the results allow a quantitative assessment of the diagnostic value of a given marker-target locus association to the total population of at-risk individuals.

ISSN:0001-5652    

DOI:10.1159/000153521

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In a factory in northern Sweden where 120 workers were uniformly exposed to photoactive substances 73 developed occupational facial eczema while 47 showed no reaction. The workers were examined with respect to 16 genetic marker systems: HLA, blood groups (ABO, Rh, MNSs, P, K, Le and Fy) and serum groups (Hp, Tf, Gc, Pi, Bf, C3, C4 and C6). Between reactors and nonreactors the following differences were found: (1) a significant decrease (p& < 0.05) of HLA A11 among the reactors; (2) a significant increase (&p< 0.05) of the C3 FS type among the reactors; (3) a highly significant increase (&p<0.001) of the transferrin C2 gene and of the C2 variant among the reactors. The association with Tf C2 remained significant also after correction for number of significance tests. Since transferrin (iron) is known to catalyze the formation of hydroxyl radicals we hypothesize that the Tf C2 variant is more efficient in promoting radical formation and thereby cell damage. Other results supporting the notion that transferrin C2 may be associated with an increased susceptibility to toxic damage are discussed.

ISSN:0001-5652    

DOI:10.1159/000153522

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The red cell enzyme phosphoglucomutase first locus (PGM1)phenotypes of 639 adult Finns were determined by isoelectric focusing in agarose gel. All the ten commonly occurring phenotypes were detected and the frequencies of the four alleles at the PGM1 locus were as follows: PGM1a1 = 0.5313, PGM1a2= 0.1800, PGM1a3 = 0.2199 and PGM1a4= 0.0689. The PGM1 phenotypes of 221 mothers with 228 offspring were in accordance with autosomal codominant inheritance.

ISSN:0001-5652    

DOI:10.1159/000153523

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The distribution of the three previously reported alleles, with normal products at the factor XIII A subunit structural locus, FXIIIA*1FXIIIA*2 and FXIIIA*4 has been studied in populations from the region extending from the Indonesian archipelago through Papua New Guinea, Australia and New Zealand to the Pacific Islands of Micronesia, Melanesia and Polynesia. In addition a population from the Caspian Littoral of Iran and a population of South American Indians were studied. The FXIIIA *1 and FXIIIA *2 alleles were polymorphic in all populations studied. The distribution of the FXIIIA* 4 allele suggests that it may be a Melanesian marker.

ISSN:0001-5652    

DOI:10.1159/000153524

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

We studied the frequencies of red cell enzyme types, AcP, PGM1 and EsD in 213 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), rheumatic heart disease (RHD), scleroderma (Scl) and psoriatic arthropathy (PsA). The differences in frequency of AcP phenotypes between RA, Scl, and PsA and the Moscow population were significant. In PsA the PGM1 phenotype 1-1 frequency was significantly decreased, while the phenotype 2-1 frequency was significantly increased.

ISSN:0001-5652    

DOI:10.1159/000153525

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In contrast to the data published by Payne and Huntsman in 1982, no association between GLO I and Hp phenotypes could be found in a sample of 973 unrelated Austrians.

ISSN:0001-5652    

DOI:10.1159/000153526

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Sneezing in response to bright light has been found in 25 % of a sample of the British population, and pedigrees are compatible with an autosomal dominant mode of inheritance. The mechanism of the response is discussed.

ISSN:0001-5652    

DOI:10.1159/000153527

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Haptoglobin and transferrin types were examined in Eti-Turks. The Hp1 frequency was 0.26. With the exception of two individuals with transferrin D, only the transferrin C was observed. The gene frequencies were in the range of most of the Asiatic populations including Turks.

ISSN:0001-5652    

DOI:10.1159/000153528

出版商:S. Karger AG    

年代:1985

数据来源: Karger