摘要:

It has been suggested that genetic counselling and therapeutic abortion can lead to increases in the frequencies of autosomal genes determining recessive diseases. Algebra for calculating the consequences of such practices is presented, together with numerical results for one generation where the effects are seen to be very slight. It is concluded that genetic counselling poses no real threat to the human gene-pool in the short term.

ISSN:0001-5652    

DOI:10.1159/000152332

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Ecclesiastical dispensations from the impediment of consanguinity were studied in relation to 190,557 marriages between two Catholics in all Ireland for the ten-year period 1959–1968. The data, based on approximately 71% of all marriages in this period, indicate a first cousin marriage rate of about 1 in 720 for all Ireland. Figures for the Republic of Ireland, based on approximately 91% of all marriages, indicate a first cousin marriage rate of about 1 in 625 for this section of the country. Various aspects of the data, including ‘isolate’ effects and the influence of itinerancy, are disc

ISSN:0001-5652    

DOI:10.1159/000152333

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

An analysis of the rate of celibacy, under 2 criteria (at the ages of 30 and 40) among the offspring of consanguineous and non-consanguineous marriages did not show significant differences both among whites and non-whites (mulattoes and negroes), in a Central Brazilian region. There is, therefore, no evidence that rare recessive genes play an important role in determining in individuals of the investigated area some disturbance of behavioral pattern that would create a resistance or difficulty to marriage. Since the population which has been studied is subdivided into a number of relatively small and ‘simple’ isolates, it is suggested that a different situation may prevail in the large and ‘complex’ isolates of the large cities. The higher prevalence of female celibates older than 40 years, as compared to males, is probably due to the preferential emigration of males, a fact that characterizes the

ISSN:0001-5652    

DOI:10.1159/000152334

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Dermatoglyphic patterns were analyzed in 141 patients with congenital heart malformations not associated with a major non-cardiac malformation, and 100 control children. The results were compared and, where possible, combined with those of other series. In the combined series, the aortic stenosis group had an increase in whorls and arches, and a decrease in ulnar loops. Patent ductus arteriosus cases showed a decrease in whorls and an increase in arches. The pulmonic stenosis group had an increase in arches. However these differences are so small that they are not diagnostically useful, and may represent nothing more than inadequate matching with controls. There were no significant differences in finger patterns in cases with tetralogy of Fallot, transposition of the great vessels, ventricular septal defect, atrial septal defect and coarctation of the aorta. There was no significant difference in frequency of bilateral simian crease in congenital heart disease. A probable increase in height of the axial palmar triradius was found in cases of tetralogy of Fallot, and there was a highly significant increase in hypothenar patterns in cases of pulmonic stenosis, aortic stenosis and transposition of the great vessels.

ISSN:0001-5652    

DOI:10.1159/000152335

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Hereditary nature of the measure of asymmetry (A2) is demonstrated by using the square root of this measure. The relationship between heritability and correlation is discussed. Heritability in all children, although low (5%), is 23% in female children and 35% in male children. The heritabilities estimated from parent-child correlations range from 20 % to 44%.

ISSN:0001-5652    

DOI:10.1159/000152336

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The distribution of electrophoretic variants in 8 red cell enzyme systems, representing 10 independent gene loci, has been examined in a large series of Marathi and Gujarati blood samples from Bombay. In the acid phosphatase system no PHsc genes were detected in Marathis and the frequency of PHsc in Gujaratis was only 0.004. The PHsB frequencies were 0.72 and 0.71 respectively. For 6-phosphogluconate dehydrogenase the PGDA frequencies were 0.97 and 0.98: a single case of the ‘Richmond’ variant was found in Gujaratis. The AK2 gene in the adenylate kinase system has a relatively high frequency, as in other Indian populations: the respective frequencies were 0.09 and 0.11. No variants were found at the PGM2 locus in the phosphoglucomutase system. For the PGMX locus PGM]1 frequencies were 0.65 and 0.69 for Marathis and Gujaratis. A single PGM 6–1 individual was found in the Marathis and a PGM 3–1 individual in the Gujaratis. No electrophoretic variant was found for the peptidase A, malate dehydrogenase or ‘oxidase’ systems. A single Pep B 2–1 person was found among the Marathis in the peptidase B system. Fourteen cases of the ‘Calcutta-1’ variant were found among 1,005 persons tested for lactate dehydrogenase. The LDH ‘Cal-1’ gene frequency was 0.0089 for Marathis and 0.005 for Gujaratis. The ‘Cal-1’ variant is widespread in India and has the highest world freq

ISSN:0001-5652    

DOI:10.1159/000152337

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Problems in regard to age-specific fertility and spontaneous abortion rates have been mentioned. Until they have been settled, interpretations of attempts to fit curves to the probability of a mongol birth at varying maternal ages must remain suspect.

ISSN:0001-5652    

DOI:10.1159/000152338

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

By means of starch gel electrophoresis the developmental changes of alkaline phosphatase isozymes have been studied in samples from small intestine, kidney, liver, gonads, heart, skin, muscle, spleen and pancreas of foetuses and adults.

ISSN:0001-5652    

DOI:10.1159/000152339

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The association between alkaline serum phosphatase phenotypes and ABO blood groups is confirmed on a sample of n = 1145 males and females from NE-Hungary (Bodrogköz). The distribution of Pp phenotypes revealed sex independence, but marked age dependence was observed. Regional heterogeneity in the distribution of Pp phenotypes found in this area therefore seems to be more likely due to different age structure of the various village samples than due to probable genetic differences. Hence population comparisons concerning the distribution of Pp phenotypes should absolutely consider the age structure of the compared populations

ISSN:0001-5652    

DOI:10.1159/000152340

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The distributions of haptoglobin and transferrin phenotypes were examined in a population sample of Africans belonging to the Basakata and Nkundu tribes in Congo. The transferrin variants Bx and Dj were observed. The frequency of the haptoglobin gene Hpl was 0.54 and a significant inbreeding effect was found with respect to the distribution of haptoglobin phenotypes.

ISSN:0001-5652    

DOI:10.1159/000152341

出版商:S. Karger AG    

年代:1970

数据来源: Karger