摘要:

The epidemiology of congenital heart disease is briefly reviewed; the main findings as well as their implications have been discussed.

ISSN:0001-5652    

DOI:10.1159/000152405

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The coefficients of kinship were computed from the migration matrix for Narata, Kumamoto prefecture, and the whole of Japan. The dimensionality of the migration is isotropic one dimension at the small and the intermediate populations except Uto city. The value of c from the whole of Japan has taken similar values from the analysis of the migration matrix and ABO blood groups bioassay, and their dimensionality of migration is one dimension. However, the value of c from pedigree analysis is between one and two dimensions.

ISSN:0001-5652    

DOI:10.1159/000152406

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Cytological and clinical observations have been presented from an abnormal human female who exhibited two chromosomally distinguishable cell lines in composition. One of her cell lines conformed with 46, XX chromosome types. On the other hand, the second cell line consisting of 47 chromosomes per cell had two unequal aberrant meta-centric chromosomes that had replaced a regular C-group autosomes. It is interpreted that these aberrant chromosomes are the isochromosomes that arose from the missing C-autosome. Since, the isochromosomes for both arms of this autosome were retained by the patient, this has produced the phenotypic features of a trisomy.

ISSN:0001-5652    

DOI:10.1159/000152407

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The G-6-PD, PGM1 and PGM3 phenotypes were examined in 16 different continuous human tumor cell lines (glioma and sarcoma) established in the Uppsala laboratory. The enzyme pattern did not deviate from that expected in a randomly drawn sample of tumors. There was no evidence of any cross-contamination between the lines or by HeLa cells.

ISSN:0001-5652    

DOI:10.1159/000152408

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Serum protein types were determined for Canadian Indians belonging to three separate linguistic groups. The Hp1 frequencies were within the range predicted on the basis of the known geographic distribution of haptoglobin types, being less than 0.50 in all but the Siouan group. Transferrin D Chinese was found in approximately 6% of Plains Crees (Algonkians) but was infrequent Canadian Indians or absent in the other groups studied. The Gc2 frequency was low in the Athabascan and Siouan groups and intermediate in Algonkians. The presence of a polymorphism for normal and a fast variant of serum albumin (albumin Naskapi) was confirmed in Algonkians and Athabascans. C5 + variants of serum cholinesterase were found an all three groups. Three pedigrees that provided information on the Gc/albumin linkage were analysed and their lod scores were combined with those from reported pedigrees. Based on the combined data, assuming allelism of different variants, the best estimate of the map distance is 2.5 centimorgans with 95% probability limits 0.9–5.0 centimorgan

ISSN:0001-5652    

DOI:10.1159/000152409

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Phosphoglucomutase types have been determined in homogenates of 660 placentas. The gene frequencies were: PGM11 0.797 and PGM21 0.203, PGM13 0.734 and PGM23 0.266. A new PGM2 phenotype was discovered during the study. There was no association between PGM1 or PGM3 phenotypes and gestational age, placenta weight, child weight orchild length.

ISSN:0001-5652    

DOI:10.1159/000152410

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The C 3 polymorphism has been studied in a population sample of 213 individuals from northern Sweden. The distribution of phenotypes was in agreement with the expectancy from a Hardy-Weinberg equilibrium.The frequencies of the genes C 31 and C 32 were estimated to be 0.2300 and 0.7700, respectively. The C 31 gene frequency was significantly different from that found among Norwegians but did not differ from that of Caucasian populations in the USA.

ISSN:0001-5652    

DOI:10.1159/000152411

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The C 3 polymorphism was studied by agarose gel electrophoresis in a series of serum samples from 148 Swedish Lapps. The frequencies of the genes C31 and C32 were estimated to be 0.027 and 0.973, respectively. The distribution of C 3 phenotypes in Swedish Lapps was significantly different from that among Swedes. Reexaminations of certain sera indicated that the previously described phenotype 2–4 may be a storage artefac

ISSN:0001-5652    

DOI:10.1159/000152412

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The C’3 types of human serum are reported for a material of 406 unrelated adults in Denmark, determined by means of horizontal high-voltage starch-gel electrophoresis. No difference in the distribution according to sex was observed. The gene frequencies found are C’31 = 0.18, C’32 = 0.82, C’33 ∼ 0.001, which are in accordance with the allele frequencies reported for other Caucasian po

ISSN:0001-5652    

DOI:10.1159/000152413

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

From a random northern German sample, gene frequencies of five red cell enzyme polymorphisms are calculated. For acid phosphatase (n = 7,059) the gene frequencies are estimated to be: pa = 0.353, pb = 0.582, pc = 0.065; for phosphoglucomutase (n = 4,403): PGM21 = 0.217, PGM11 = 0.783; for adenylate kinase (n = 2,370): AK1 = 0.966, AK2 = 0.034; for adenosine deaminase (n = 1,070): ADA1 = 0.945, ADA2 = 0.055, and for 6-phosρho-gluconate dehydrogenase (n = 1,162): PGDA = 0.9798, PGDB = 0.0202. A good agreement between observed and expected numbers has been found except in the acid phosphatase system. Comparative population genetic studies reveal certain north to south differences for three polymorphisms. The frequencies of the genes pb, pc, PGM21 and ADA2 seem to be significantly higher in southern European populations than in northern and middle Europeans which seem to be rather similar

ISSN:0001-5652    

DOI:10.1159/000152414

出版商:S. Karger AG    

年代:1971

数据来源: Karger