摘要:

The effects of parental consanguinity, age, and sex on defects of the eye and ear, accomodation, mean visual acuity, and mean decibels of hearing loss at four frequencies have been investigated in a series of Middle School children and their parents on Hirado Island, Japan. In the children the effect of paternal and maternal inbreeding on these same indicators has also been investigated. The numbers available for the various analyses after eliminations for incompleteness of records, and confining the analysis to children where socioeconomic data are complete, are given in table III. Age and sex effects are encountered at high levels of statistical significance, but, unlike the results on Hirado with respect to a variety of other indicators [Schull et al., 1970; Neel et al., 1970], socioeconomic effects are negligible. None of the regressions on consanguinity or inbreeding is individually significant, nor is there any consistent pattern to the totality of the regressions. On the other hand, the sampling errors are such that the data cannot be said to conflict with the significant positive findings regarding consanguinity effects in a previous study in Hiroshima and Nagasaki [Schull and Neel, 1965].

ISSN:0001-5652    

DOI:10.1159/000152303

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The clinical and haematological data of nine patients with haemoglobin H disease, as well as of 16 members of their families, are reported. Pedigree study and haematological data permit the assumption that in an individual four genes could be responsible for α-chain synthesis. Based on this hypothesis, four variants of α-thalassaemia are expected to exist. The first, in which only one gene is affected has no, or only minor, red cell changes and an increase in Hb Bart’s at birth, the second with two genes affected has in addition Hb H inclusion bodies in a few red cells, the third, with three genes affected represents haemoglobin H disease, and the fourth, with all four genes affected, represents homozygous α-thalassaemia, which is incompatible with life and results in a stillborn child with hydrops foet

ISSN:0001-5652    

DOI:10.1159/000152304

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

This note presents revised model derivations for pigmentation distributions in the Negro-American. Instead of the formerly accepted estimate of 30% Caucasian alleles the recent estimate of 20% has been used. Best agreement with observations is obtained from 3 and 4 pair models. The uncertainties of the treatment are emphasized.

ISSN:0001-5652    

DOI:10.1159/000152305

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The theory of Malecot about the decrease of kinship with distance was tested with a big material of ABO blood groups distributed all over Belgium. The kinship, calculated from the frequency of random pairs of blood groups decreases exponentially with a good fit to the theory. Subdivisions of Belgium are also studied in the same way and differences between regions according to inbreeding and distances between mates are discussed.

ISSN:0001-5652    

DOI:10.1159/000152306

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The ADA types of human red cells are reported for a material of 1321 unrelated adults in Denmark. The gene frequencies observed are: ADA1 = 0.9391 and ADA2 = 0.0609. The study of 754 mother-child pairs provides further evidence for a simple Mendelian codominant way of inheritance.

ISSN:0001-5652    

DOI:10.1159/000152307

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Evidence is presented suggesting that the heat-stable alkaline phosphatase of HeLa cells is identical with a specific genetic variant (Sx) of placental alkaline phosphatase.

ISSN:0001-5652    

DOI:10.1159/000152308

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The relation between the ABO blood groups and the serum level of the heat-stable placental alkaline phosphatase was studied in a series of about 400 pregnant women. The claim by other investigators that significantly lower enzyme levels are found in mothers of blood group 0 could not be confirmed in this investigation. No association was found between the ABO blood groups and the heat-sensitive (liver) alkaline phosphatase. Thus conclusive evidence for a blood group association has so far been established for intestinal alkaline phosphatase only.

ISSN:0001-5652    

DOI:10.1159/000152309

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The placental alkaline phosphatase types have been determined in a series of 374 Japanese placentae. Nine different phenotypes were observed, and the gene frequencies for the common phenotypes are calculated Pls1 = 0.721, Pli1 = 0.225 and Plf1 = 0.043. In contrast to reports on Caucasians, the high Pli1 and the low Plf1 are characteristic of the present study. Rare alleles probably corresponding to Pls2 and Pls3 are also present and a new phenotype tentatively designated S1SJ is described.

ISSN:0001-5652    

DOI:10.1159/000152310

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Phenotype- and gene-frequencies of red cell acid phosphatase in the Polish population have been determined. Analysis of a family material supports the genetic hypothesis that the acid phophatase is controlled by three codominant allelic genes. The utility of determination of acid phosphatase types in twin studies, paternity testing and in anthropological investigations is discussed.

ISSN:0001-5652    

DOI:10.1159/000152311

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

A series of 456 serum samples obtained from blood donors in Central Blood Bank, Calcutta, were examined by starch gel electrophoresis for haptoglobin types, and 424 samples out of them were examined for transferrin types. Hp1 gene-frequency was 0.16, and the HpO frequency just under 1%. The first case of Hp ‘Johnson’ in India was detected in a Bengali Hindu. No transferrin variants were detected, all being of the common CC t

ISSN:0001-5652    

DOI:10.1159/000152312

出版商:S. Karger AG    

年代:1970

数据来源: Karger