摘要:

The serum Gc, Hp and α2HS phenotypes were examined in 64 subjects known to have the human T-lymphotropic leukemia virus type I (HTLV-I) infection and in 60 uninfected subjects. There were no significant differences in the distributions of Gc, Hp and α2HS phenotype and allele frequencies between any grouping of HTLV-I-infected subjects and the controls. No association between the Gc, Hp and α2HS genotypes and susceptibility to adult T-cell leukemia was fou

ISSN:0001-5652    

DOI:10.1159/000153940

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Two sisters in a Hei//om family of the southern African Khoisan race in Namibia were found to have Wd(a+) red blood cells. Wda is a low-frequency antigen identified so far only in a European family in Canada and a family in Holland. The Wda gene may have had an independent origin in the Khoisan. Alternatively, the Hei//om population may have acquired it through miscegenation.

ISSN:0001-5652    

DOI:10.1159/000153941

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The phenotypes and gene frequencies of 3 blood groups, 7 red-cell enzymes and a serum protein were studied in 4 caste population groups of Haryana, North India. The results indicate that the distribution of these blood markers is rather homogeneous in the 4 groups and generally resembles that observed in various populations from neighbouring North Indian states.

ISSN:0001-5652    

DOI:10.1159/000153942

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

A new separator isoelectric focusing method for typing of orosomucoid (ORM) was developed. This method provided a superior resolution of ORM patterns: two close bands of ORM1*5.2 products were clearly separated. A total of 364 subjects from Okinawa (Japan) were classified into 21 ORM phenotypes determined by 6 ORM1 and 7 ORM2 alleles including a polymorphic silent allele, ORM2*QO, and 2 new rare variants, ORM2*18 and ORM2*19. These phenotypes were also explained by 12 ORM haplotypes, half of which were polymorphic.

ISSN:0001-5652    

DOI:10.1159/000153943

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

A mutant variant of the serum protein transthyretin (TTR-met30) appears to be a necessary but not sufficient condition for the development of familial amyloidotic polyneuropathy (FAP). We have studied a number of serum protein markers (α1-antitrypsin, properdin factor B, C3, C4A, C4B, haptoglobin, transferrin and group-specific component) in FAP patients and healthy controls in an attempt to identify additional pathogenic factors which may influence the risk for developing FAP in male and female patients as well as the age of onset of the disease. Statistically significant associations were found in the complement systems C3 and C4A. The C3F variant was significantly increased in all FAP patients with a relative risk (RR) of 2.0, more pronounced in female patients (RR = 2.6) and patients with an early onset of the disease (RR = 4.5). In the FAP patients only the variants A3 and A4 were found in the C4A system. C4A3 was found in all patients, which was significantly higher than in the controls. The remaining serum protein systems showed no statistically significant associations with FAP. The results suggest that genetic variants of complement factors C3 and C4A may interact with the mutant TTR-met30 by modifying the expression and onset of FAP

ISSN:0001-5652    

DOI:10.1159/000153944

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

A large inbred Italian kindred with 10 members homozygous for the rare Rh gene complex –D–is described. The propositus has immune antibody to a high-incidence Rh antigen: her baby required exchange transfusion. None of the other 9–D–/–D– individuals has made antibody even though 2 were women with children. This kindred supports previous observations of the excess of consanguinity among the parents of –D–homozygotes. 40.9% (instead of the 25% expected) of the offspring of –D– heterozygous parents are

ISSN:0001-5652    

DOI:10.1159/000153945

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

β-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical Hindlll restriction fragment length polymorphism detected with pRK29, a 3’ β-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the β-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in or

ISSN:0001-5652    

DOI:10.1159/000153946

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

No difference in HLA-A, B or DR gene frequencies could be observed between 172 control subjects and 180 HIV-1-seropositive subjects of European ancestry diagnosed through the systematic screening of blood donations. In contrast, progression to acquired immune deficiency syndrome (AIDS; 21 patients) or CD4 lymphocyte loss equal or more than 20% over a 6-month period (37 subjects) was found to be associated with the B8DR3 haplotype (relative risk = 10.64, p < 0.003, and 2.23, p < 0.092, respectively). Other independently significant associations assessed through the multivariate Cox proportional-hazards model were B16, BW21 and B35 alleles as factors of bad prognosis. Conversely, A1 and DR4 alleles were factors favouring longer survival.

ISSN:0001-5652    

DOI:10.1159/000153947

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Five Italian samples were examined for an EcoRI restriction fragment length polymorphism associated with a DNA sequence of unknown function, located on chromosome 5. No significant difference was observed between the samples. The allele frequencies in Italy were D5S4 ES = 0.697, D5S4 EF = 0.303.

ISSN:0001-5652    

DOI:10.1159/000153948

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Orosomucoid (ORM) of plasma from 287 Japanese was typed by polyacryl-amide gel isoelectric focusing followed by immunoprinting with specific antiserum to ORM. Two new variants were observed and they were designated ORM2 16 and ORM2 17.

ISSN:0001-5652    

DOI:10.1159/000153949

出版商:S. Karger AG    

年代:1990

数据来源: Karger