摘要:

We report here the reaction pattern of a local serum (C2487) with antigens B7 and Bw73, and data from an intercross family in which B7 and Bw73 antigens segregate as alleles.

ISSN:0001-5652    

DOI:10.1159/000153703

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Transferrin and group-specific component subtypes were studied by isoelectric focusing of sera from 253 Parsis in India. The frequencies of TfC1, TfC2, TfC3 and TfC4 were found to be 0.8083, 0.1719, 0.019 and 0.0020, respectively. TfB was present in a frequency of 0.0059. The frequencies of Gc alleles were found to be 0.4478 for Gc1F, 0.3875 for Gc1S and 0.1647 for Gc2. The gene frequency of Gc1F was rather high in comparison with Iranian and Indian populations.

ISSN:0001-5652    

DOI:10.1159/000153704

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

During an extensive investigation to determine the frequency of sickle cell and thalassaemia genes in the Saudi population, 22 cases with S/β°-thalassaemia were identified and the haematological, biochemical and clinical findings were compared with those in patients with sickle cell anaemia. The values of mean cell volume, mean cell haemoglobin and packed cell volume were found to be lower while all other haematological parameters including Hb A2 were higher in the S/β°-thalassaemia group. No statistically significant difference in the Hb F level was found between the two groups. Biochemical parameters were grouped according to organ function tests. Only slight differences were seen in the values of some parameters. The clinical data showed that, in general, patients with sickle cell anaemia had a more severe condition than the S/β°-thalass

ISSN:0001-5652    

DOI:10.1159/000153705

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A sample of healthy unrelated individuals was typed for properdin factor B (Bf) polymorphism in four Sardinian villages. Two villages, Desulo and Tonara, are located in the highlands; the other two, Orosei and Galtelli, are located in the lowlands. No heterogeneity was found between the highland and the lowland villages, whereas a significant difference was found between the Sardinian villages and continental Italy. The allele Bf-F1 shows the highest gene frequency so far observed. Typically Sardinian is the gametic association (haplotype) HLA-A30, Cw5, B18, BfF1, DR3.

ISSN:0001-5652    

DOI:10.1159/000153706

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

In elucidating the etiology of complex diseases through various epidemiologic and genetic analyses, it is necessary to define the expected risks for each member of a pedigree collected through an affected individual. It is shown that several factors are to be considered without which such expected risk estimates may be biased. The presence of secular trends in disease incidence introduces a bias in familial relative risk estimates, the magnitude and direction of which may be judged from the nature of the secular trends and the age and cohort composition of the individuals included in the study. Nonrandom follow-up time of the relatives, on the contrary, produces a bias in relative risk estimates, the magnitude and direction of which cannot be ascertained without any prior assumption about the distribution of follow-up time. In addition, competing causes of diseases and risk heterogeneity among different relatives and among families are also sources of indeterminate biases, which must be removed in order to interprete the results of relative risk studies and segregation analysis of discrete disease traits.

ISSN:0001-5652    

DOI:10.1159/000153707

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The genetic polymorphism of red cell delta aminolevulinate dehydrase (ALADH) has been investigated in several population groups in Israel: Ashkenazi Jews, non-Ashkenazi Jews from North Africa, Egypt, Turkey, Iraq, Iran, Yemen and the Balkans, and Arabs. The distribution of the ALADH genes was not homogeneous (χ2 = 36.83; d.f. = 8; p < 0.0005). A significantly higher frequency of the ALADH2 gene was observed among the Ashkenazi Jews (0.2021) than among the non-Ashkenazi Jews and Arabs (gene frequencies 0.0825–0.1290) or all the other population samples so far studied (Liberia, Japan, Italy, Germany and Spai

ISSN:0001-5652    

DOI:10.1159/000153708

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Alpha-1-antitrypsin subtypes were studied in resident (644) and native (222) individuals from the Spanish Basque Country. The gene frequencies were similar to those in other Spanish populations but the isolated valley of Arratia deviated significantly with increased frequencies of the M2 and M3 alleles and a decrease of the M1 allele.

ISSN:0001-5652    

DOI:10.1159/000153709

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

To investigate β-globin gene polymorphism in the Saudi population, samples from 436 individuals from the eastern and north-western provinces of Saudi Arabia were studied using restriction endonucleases Mst II and Hpa I. Three individuals with haemoglobin genotypes AA, AS and SS were identified to each have a 5.6-kilobase (kb) Hpa I fragment in addition to a 13.0-kb fragment. This paper reports for the first time in Saudis a linkage of both the βAand βBgenes to a 5.6-kb Hpa I fragme

ISSN:0001-5652    

DOI:10.1159/000153710

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Human HLA-linked complement C4 gene products, C4A and C4B, show extensive genetic polymorphism. In both loci, an allele without a gene product, C4 null, is also observed. We have performed a restriction enzyme analysis of genomic DNA samples from individuals having all common (frequency over 1 %) C4 protein allotypes observed in the Finnish population. Only one allotype-specific RFLP marker was observed. With some enzymes a DNA polymorphism was observed, which was not detectable by C4 protein typing. Analysis of 10 different C4B null haplotypes and 4 C4A null haplotypes suggested that only one haplotype, HLA-B8 C4A0 B1, carried a C4A gene deletion. This was observed in all 4 unrelated individuals homozygous for this haplotype.

ISSN:0001-5652    

DOI:10.1159/000153711

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

From populations of the Indian subcontinent Gc subtypes were investigated in 14 socioculturally diverse groups. The tribal populations showed a greater differentiation at this locus than the caste and Muslim groups. This marked difference between tribal populations is likely to be due to their breeding structure and historical affiliation, although a possible effect of natural selection cannot be ruled out.

ISSN:0001-5652    

DOI:10.1159/000153712

出版商:S. Karger AG    

年代:1987

数据来源: Karger