摘要:

Associations have been found between self-reported cold symptoms and Pi type in 84 pairs of identical twins. The risk of cold symptoms relative to MM phenotypes was 1.2 times greater in MS and 2.5 times greater in MZ individuals. Up to 9% of variance in cold symptoms could be attributed to Pi type, representing at least 20% of the total genetical variance.

ISSN:0001-5652    

DOI:10.1159/000153389

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Blood specimens were studied from 213 persons aged 3–51 years, in Olkusz, a town between Krakow and Katowice in south Poland. The data show general similarity in blood groups and red cell enzymes to those from other central European populations, but in several systems there are suggestions that Polish frequencies are somewhat peripheral, for example phosphoglucomutase, acid phosphatase, esterase D, while in others where clines exist the results fit well into those expected from the geographical position of the sampl

ISSN:0001-5652    

DOI:10.1159/000153390

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Familial correlations are available for individuals reared by biological and foster parents, with and without indices of relevant environment. Five data sets give estimates of genetic heritability which range from 0.194 to 0.360 for systolic pressure and from 0.147 to 0.346 for diastolic pressure. Concomitant estimates of cultural heritability due to common family environment range from 0.042 to 0.183 for systolic pressure and from 0.008 to 0.310 for diastolic pressure. There is good resolution of genetic and environmental determinants. Most of the variance is due to random environment and errors of measurement. Although estimates of variance components are spatiotemporally limited to particular populations, there is good agreement among data sets.

ISSN:0001-5652    

DOI:10.1159/000153391

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The paper presents a survey of arterial blood pressures measured in 193 adult males and females of Relli community, selected at random from Visakhapatnam City, Andhra Pradesh. Age shows more influence on the rise of systolic than diastolic blood pressure. Females show a higher rate of rise in both pressures with advancing age. The incidence of hypertension is also found to be higher in females than in males.

ISSN:0001-5652    

DOI:10.1159/000153392

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Mendelian likelihoods are computed from human pedigree data for purposes of gene mapping, risk prediction in genetic counseling, and hypothesis testing in genetic epidemiology. The Mendelian likelihood of an extended pedigree can be written as a sum of products, the sum ranging over all possible genotypic combinations for the individuals in the pedigree. Exclusion of genotypes incompatible with the phenotypic information and pedigree structure reduces the ranges of summation and simplifies the likelihood calculation. To evaluate the likelihood with the fewest possible arithmetic operations requires carrying out the summations over one individual at a time and the intervening multiplications in some appropriate order. Each such removal of an individual reduces the likelihood evaluation to another evaluation of the same numerical form. Greedy-type algorithms are suggested for determining an order in which the summations and multiplications may be carried out. The greedy methods are fast and appear to generate good removal sequences. They are shown to work well when applied to a large, complex pedigree.

ISSN:0001-5652    

DOI:10.1159/000153393

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Hp typing and Tf, Gc and Pi subtypings were performed on 144 serum samples from a Nepalese population in the Katmandu Valley, Nepal. The obtained allele frequencies are as follows: Hp1 = 0.1771, Hp2 = 0.8229; TfC1 = 0.7222, TfC2 = 0.2500, TfC3 = 0.0174, TfCnepal(TfC9) = 0.0104; Gc1F= 0.2448, Gc1S = 0.4825, Gc2 = 0.2727; PiM1 = 0.6076, PiM2 = 0.2118, PiM3 = 0.1806. The relationship between this sample population and the Indian population is discussed.

ISSN:0001-5652    

DOI:10.1159/000153394

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In the Bengali-speaking population of Calcutta (India) the genotype frequencies of the Hbβ-A/E/T system are given. The fitness of the genotypes has been calculated. It is found that this system is not in stable or semistable equilibrium in this population

ISSN:0001-5652    

DOI:10.1159/000153395

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Red blood cell zinc levels vary linearly with age within each sex. Age- and sex-adjusted zinc levels generated 6 familial correlations in nuclear families and twins. A simple additive polygenic model, with genetic heritability of zinc (h2) as the only unknown parameter, gave an excellent fit (χ25 = 0.96), with the corresponding estimate of h2 = 0.790 ± 0.032. Commingling analysis supported the hypothesis that the logarithmic zinc values are approximately distributed according to a mixture of three normal distributions. Some support was found for a major gene hypothesis by complex segregation analysis under the mixed model. However, all the evidence came just from one family in which one of the 3 children’s zinc value was over 3 standard deviations above the mean. When that family was excluded, there was no more evidence for a major gene. Under the most parsimonious mutlifactorial model that assumes equal heritabilities in children and adults, the heritability was estimated as 0.748 + 0.079, in good agreement with the outcome of path analysis. Biological interpretations are put forward and discus

ISSN:0001-5652    

DOI:10.1159/000153396

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The polymorphism of red cell glutamic-pyruvic transaminase (GPT) was studied in 277 unrelated voluntary blood donors from the population of Serbia (Yugoslavia). The following phenotype frequencies were observed: GPT 1 0.309, GPT 2–1 0.454 and GPT 2 0.206, while gene frequencies were: GPT10.556 and GPT20.45

ISSN:0001-5652    

DOI:10.1159/000153397

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A dermatoglyphic study was made of two high-altitude populations inhabiting the same ecozone in extreme northwest Nepal. Despite cultural and linguistic differences there appears to be a significant amount of dermatoglyphic homology between the Buddhist-Tibetan villages and their Hindu-Caucasian neighbors.

ISSN:0001-5652    

DOI:10.1159/000153398

出版商:S. Karger AG    

年代:1983

数据来源: Karger