摘要:

AbstractThe preparation of a hydroxymethylstyrene‐2%‐divinylbenzene polymer is described.The optimal method for the esterification of this polymer withN‐t‐butoxy‐carbonyl amino acids was found by usingN,N′‐carbonyldiimidazole, the remaining hydroxyl groups being protected by formation of their acetates.On this polymer the nonapeptide sequence of the hormone oxytocin was synthesized and then split off in two ways. Tertiary base‐catalysed methanolysis (found in this Laboratory) gave the nonapeptide methyl ester: Z‐Cys(BZL)‐Tyr‐Ile‐Gln‐Asn‐Cys(BZL)‐Pro‐Leu‐Gly‐OMea.L‐Amino acids are meant. b. Abbreviations used here and later: IUPAC, Information Bulletin25, February 1966, 32‐40;26, August 1966, 11‐19;27, December 1966, 16‐18;30, October 1967, 27‐32., and ammoniacal methanol gave the carboxy‐terminal amide: Cys(BZL)‐Tyr‐Ile‐Gln‐Asn‐Cys(BZL)‐Pro‐Leu‐Gly‐NH2(H2O · HBr).The usual debenzylat

ISSN:0165-0513    

DOI:10.1002/recl.19690880902

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

AbstractMixtures of 2,6‐ and 2,7‐di‐t‐butylnaphthalene, obtained by thet‐butylation of naphthalene, can be conveniently separated making use of the fact that only the 2,6‐isomer gives an inclusion compound with thiourea.1,4‐ and 1,5‐di‐t‐butylnaphthalene as well as 1,4‐ and 1,5‐diisopropylnaphthalene have been prepared starting from 1,4‐ and 1,5‐naphthalene‐dicarboxylic acid, respectively. The NMR spectra of these compounds reveal downfield shifts for theperiprotons.1,8‐Diisopropylnaphthalene was synthesized by an eight step synthesis starting from 1,8‐

ISSN:0165-0513    

DOI:10.1002/recl.19690880903

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

AbstractProton magnetic resonance spectra of a number of simple alkenesulfonic acids and related hydroxyalkanesulfonic acids have been measured. The compound described in the literature as 2‐methylpropene‐1,3‐disulfonic acid (I) has been found to be 2‐methylenepropane‐1,3‐disulfonic acid (II). Interconversion of I and II and of the 1‐ and 2‐propene‐1‐sulfonic acids can be effected at 100° in 1N‐sodium hydroxide as well as concentrated sulfuric acid. The equilibration of 2‐propene‐1‐sulfonic acid and the hydrogen sulfate of 2‐propanol‐1‐sulfonic acid in sulfuric acid is much faster than the equilibration of these two compounds with 1‐propene‐1‐sulfonic acid and is thought to involve intramolecular catalysis. Double‐bond isomerization of 2‐methyl‐2‐propene‐1‐sulfonic acid can only be effected under alkaline conditions since this compound reacts rapidly with sulfuric acid to give eventually the disulfonic acids.Equilibrium constants for isomeric α,β‐ and β,γ‐unsaturated sulfonic acids are reported. The base‐catalysed isomerizations are much slower than the hydrogen‐deuterium exchange of the α‐hydrogens; the rate of acid‐catalysed exchange of both types of h

ISSN:0165-0513    

DOI:10.1002/recl.19690880904

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19690880905

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

Abstract17α‐Alkylated derivatives of 5‐estren‐17β‐ol and their 7α‐methyl homologues have been prepared (Chart I). The key step in these syntheses is the reduction of the 3β‐chloro‐5‐estrenes (IV) with lithium in liquid ammonia.Similar derivatives of the 5(10)‐estrenes have been synthesised (Chart II). The preparation and the reduction of the dithio‐acetals VIII are discussed. 5(10)‐Estren‐17‐one has been obtained together with other double bond isomers by iso

ISSN:0165-0513    

DOI:10.1002/recl.19690880906

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

AbstractOptical rotatory dispersion and circular dichroism data are given for eight prostaglandins. An interpretation of the data is given in terms of the conformation of the cyclopentanone ring.

ISSN:0165-0513    

DOI:10.1002/recl.19690880907

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19690880908

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

AbstractNMR spectroscopy reveals that the reaction between hepta‐1,3,5‐triene and potassium amide yields theall‐transheptatrienyl anion, which readily isomerizes to the cycloheptadienyl

ISSN:0165-0513    

DOI:10.1002/recl.19690880909

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19690880910

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY

摘要:

AbstractUnsuccessful attempts to prepare ethylenediiminobisacetylacetonezinc led to the isolation of a novel compound ethylenediiminobisacetylacetonezinc dichloride following a procedure similar to that introduced byRamaiahandMartinK. RamaiahandD. F. Martin, J. Inorg. Nucl. Chem.27, 1663 (1965).. A tentative structure of ethylenediiminobisacetylacetonezinc dichloride is proposed from UV, IR, NMR, and conductance data.

ISSN:0165-0513    

DOI:10.1002/recl.19690880911

出版商:WILEY‐VCH Verlag    

年代:1969

数据来源: WILEY