摘要:

AbstractThe reaction ofp‐cymene withtert.amyl alcohol or methylbutenes in the presence of sulphuric acid or withtert.amyl alcohol ortert.amyl chloride in the presence of aluminium chloride according to the Friedel Crafts method, has been found to yield a polymethylindan mixture consisting of41%of 1,1,2,3,3,5‐hexamethylindan (XXI),23%of 3‐ethyl‐1,1,3,5‐tetramethylindan (XX), and12%of 1,1,3,3,5‐pentamethylindan (III). In addition, 1,2,3,3,5‐pentamethylindan (II) and 1,1,2,3,5‐pentamethylindan (I) have been synthesized.Introduction of an acetyl group into the aromatic nucleus of the first four indans results in indanyl methyl ketones having a musk odour, acetyl‐1,1,2,3,3,5‐hexamethylindan (XXVIII) being the most

ISSN:0165-0513    

DOI:10.1002/recl.19550741001

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractLaurie, linolenic, and linoleic acids have been shown to cause a considerable growth response in theWehneltbean test. The action of these acids is enhanced in the presence of coenzyme A, cytochrome C, and ascorbic acid. The growth response to lemon peel infusion and pressed orange oil is attributed in part to the presence of these substances.

ISSN:0165-0513    

DOI:10.1002/recl.19550741002

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractThe plant pigments (“chromogens”) in extracts of fresh grass and feces from cows in 85 per cent (by volume) acetone, applied as digestion trial markers, have been separated and determined chromatographically. In the extracts of fresh grass chlorophyll (converted into pheophytin by oxalic acid), carotene, xanthophyll, and a small amount of porphyrins could be determined. In feces pheophytin, carotene, xanthophyll, phylloerythrin, and other porphyrins not yet defined could be detected.The application of naturally occurring plant pigments as Indicators in the determination of the digestibility of feed by ruminants has been discus

ISSN:0165-0513    

DOI:10.1002/recl.19550741003

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractDiazotetronic anhydride, which contains the (N2)CHCO.O.CH2‐grouping ‐ characteristic for the antibiotic azaserine ‐ in a cyclic structure was assayed for inhibitory activity in a number of tests, together with a series of its γ‐substituted derivatives and some related compounds. The properties of diazotetronic anhydride parallel those of azaserine to a large extent. In some cases its antibacterial activity is higher than that of the antibiotic. The activity of the structurally related 3‐chlorobenzene‐6‐diazo oxide againstEbert. typhipractically equals that of chloramphenicol(in vitro).The blastocoline activity (inhibition of seed‐germination) of diazotetronic anhydride is comparable with that of coumarine, while rootgrowth inhibition is of the same order as in the case of azaserine. Oxygen consumption by rat liver homogenate is reduced by addition of the compound.At low concentrations filament formation inE. coli(inhibition of cell division) is observed.Structural similarities between diazotetronic anhydride, benzenediazo oxides, diazouracil, the antibiotics azaserine and cycloserine (oxamycine) and the internal salt of 2,5‐bis‐ethylenimino‐hydroquinone (highly active against a number of transplantable tumors) are pointed out, also in connection

ISSN:0165-0513    

DOI:10.1002/recl.19550741004

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractSolutions of about equal amounts of 7‐dehydrocholesterol‐3‐C14and (inactive) lumisterol3were irradiated with ultra‐violet light (265‐280 mμ) for short periods of time, resulting in approximately 10% conversion of the provitamin. Similar experiments were performed with labelled ergosterol (obtained by growing yeast in a medium containing acetate‐1‐C14), admixed with inactive lumisterol2and tachysterol2. Isolation of the compounds present in the irradiated solutions was effected by precipitating the pro‐vitamin D with digitonin and separating the remaining components according to their different rates of reaction with maleic anhydride (tachysterol>vitamin D>lumisterol). The specific radio‐activities of the products isolated gave clear‐cut evidence that lumisterol does not play any part as an intermediate in the main route of the reaction provitamin D → tachysterol nor in the conversion provitamin D → vitamin D. Besides, lumisterol seems to be formed at a relatively low rate under the conditions employed, which are comparable with those generally used in vitamin D synthesis. As to tachysterol, here conclusions were somewhat less definite because this compound has rather a high rate of photochemical formation and decomposition and is difficult to purify. The specific activity measurements, however, strongly supported the conclusion that also tachysterol is not a necessary intermediate in the vitamin D formation. Thus the results are contradictory to the traditional scheme provitamin Dlumisteroltachysterolprevitamin D ⇄ vitamin D, and are strongly in favour of a reaction pat

ISSN:0165-0513    

DOI:10.1002/recl.19550741005

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractMeasurements of absorption spectra in the ultra‐violet as well as in the visible (red) region were used to study the tautomeric equilibria in the case of p‐benzoquinone monoxime, 3‐chlorobenzoquinone‐4‐monoxime, naphthoquinone monoxime, and anthraquinone monoxime.In die case of the benzoquinone monoxime ‐ and less easily also with the chloroquinone monoxime ‐ the presence of the nitrosophenol form could be traced and its amount could be estimated. This was not possible with the naphthoquinone monoxime and the anthraquinone monoxime, which in solution seem to consist almost completely of the quinonoid form. A short theoretical comment is given.Experimental results and conclusions concerning the spectra of nitroso‐benzenes in general are discussed. Complications that may be caused by dimerization phenomena and by electrolytic dissociation of the compounds investigated were studied.Some nitrosophenols were found to be rapidly etherified at room temperature in methanol (and less quickly also in other alcohols) which had been acidified by addition of a few per cent, of concentrated hy

ISSN:0165-0513    

DOI:10.1002/recl.19550741006

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractA new method is given for the preparation of aromaticisothiocyanates from the corresponding dithiocarbamates. The latter compounds are converted into S‐(carboxymethyl) ‐dithiocarbamates, which spontaneously decompose at pH 7 in the presence of certain heavy metal ions to yield isothiocyanates. The reaction mechanism is discus

ISSN:0165-0513    

DOI:10.1002/recl.19550741007

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractWith plant growth substances there exists a certain (spatial) equivalence, as to physiological activity, between tetrahydro α‐naphthoic acids and both β‐substituted α‐napthoic acids and 2,6‐disubstituted benzoic acids.It was tried therefore whether in the highly active oestrogens of the bisdehydrodoisynolic acid type the tetrahydro β‐napthoic acid part could be replaced by a di‐ortho substituted β‐naphthoic acid structure, while retaining activity.For this reason 1,3‐dimethyl‐7‐hydroxyphenanthrene‐2 carboxylic acid was synthesized. In theAllen‐Doisytest, however, only a slight indication of oe

ISSN:0165-0513    

DOI:10.1002/recl.19550741008

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractA number of indan and tetralin derivatives with structural features characteristic of highly active morphine substitutes were synthesized.The compounds were tested for analgesic and antispasmodic activity. In none of the cases, however, these activities came up to the level required for practical application.

ISSN:0165-0513    

DOI:10.1002/recl.19550741009

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY

摘要:

AbstractFür die Anfärbung der Eiweissfraktionen auf Filtrierpapier wird Amidoschwarz benutzt, weil dieser Farbstoff ein sehr gutes Bindungsvermögen mit Protein hat und unabhängig von der Auswaschmethode mit den verschiedenen Eiweissfraktionen ein konstantes Bindungsverhältnis aufweist.Der Nachteil der schweren Auswaschbarkeit des Amidoschwarz an der nicht mit Eiweiss beladenen Stelle, wird beseitigt indem man einen einfachen Apparat gebraucht, worin die Papierstreifen bei 65° C mit 1%‐iger Essigsäure ausgewaschen werden.Nach eingehenden Untersuchungen der photometrischen Auswertung, haben wir die Folgerung gezogen, dass diese Methode aus prinzipiellen Gründen verwerflich ist.Deshalb wird die Elutionsmethode benutzt. Die Ursache der Unbeständigkeit von Amidoschwarz in Lauge wird untersucht, weil diese Unbeständigkeit selbstverständlich eine genaue Bestimmungsmethode verhindert.Es wurde gefunden, dass die Unbeständigkeit ihre Ursache in der Anwesenheit von Schwermetall‐ionen in Lauge hat, was durch Zufügung von “Komplexon” völlig beseitigt werden kann.Eiweissmengen bis 0.75 mg auf 2 cm2Filtrierpapier weisen ein genaues lineares Verhältnis auf mit der Menge gebundenem Farbstoff.Die verschiedenen Eiweissfraktionen können nach Papierelektrophoretischer Trennung mit einer sehr geringen Fehler bestimmt werden.Für Alb. ± 0.5; α1± 0.3; α2± 0.3; β ± 0.3 und γ ± 0.4 rel. Prozente.Mit unserer Methode konnten bei 45 gesunden Personen Normalwerte bestimmt werden.Albumin 69.8 ± 1.5; α1‐Glob. 3.3 ± 03; α2‐Glob. 6.3 ± 0.6

ISSN:0165-0513    

DOI:10.1002/recl.19550741010

出版商:WILEY‐VCH Verlag    

年代:1955

数据来源: WILEY