ISSN:0165-0513    

DOI:10.1002/recl.19640830702

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractA further investigation has been made of the pathway of the photo‐formation of lumisterol, which had remained doubtful after the previous analyses of irradiation mixtures, in which lumisterol was determined indirectly3. Experiments using tachysterol3‐7‐3H reveal that lumisterol is not formed directly from tachysterol to a significant extent. Thin layer chromatograms of mixtures obtained after various times of irradiation starting with solutions of pre‐calciferol3and tachysterol3indicate the direct formation of lumisterol3from precalciferol3. The modified scheme of interrelationships between pro‐ and pre‐vitamin D, lumisterol and tachysterol is essentially the one originally postulated byVelluz, AmiardandGoffinet11. The question whether ergosterol and tachysterol yield other photo‐products besides precalciferol remains to be

ISSN:0165-0513    

DOI:10.1002/recl.19640830703

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractPeptides with the “angiotensin” sequence X‐Val‐Tyr‐Ile‐His‐Pro‐Phe1have been synthesized in which X represents H, L‐Arg, D‐Arg, L‐Har, D‐Har, L‐Lys, D‐Lys, L‐Hly, D‐Hly, L‐Orn, L‐Cit, L‐Asp(NH2) ‐L‐Arg, L‐Asp(NH2) ‐D‐Arg and Gly‐L‐Arg1.The relation between structure and configuration versus pressor activity of these peptides is briefly discussed. One of the regularities found is that the heptapeptides having a D‐(N‐terminal) residue show significantly higher act

ISSN:0165-0513    

DOI:10.1002/recl.19640830704

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractExperimental data are reported on the syntheses of the angiotensin II hexapeptide Val‐Tyr‐Ile‐His‐Pro‐Phe and of the heptapeptides obtained by coupling the hexapeptide benzyl ester with thep‐nitrophenyl esters of benzyloxycarbonyl L‐lysine, D‐lysine, L‐ornithine and L‐citrulline and subsequent hydrogenolysis of th

ISSN:0165-0513    

DOI:10.1002/recl.19640830705

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractIn a previous communicationPaper no. II:C. Schattenkerk, G. Heymens Visser, K. E. T. KerlingandE. Havinga, Rec. Trav. Chim.83, 677 (1964)the syntheses of four heptapeptides related to angiotensin II were reported, in which the L‐arginine moiety was replaced by L‐and D‐lysine, L‐ornithine and L‐citrulline. We now report experimental details of the synthesis of four other heptapeptides and three octapeptides. The activity of these compounds in the pressor tests have been discussed in publication no. I of this series. The arginine and homoarginine heptapeptides were synthesized by coupling the mixed anhydride of the appropriate Z‐nitro compound with the hexapeptide benzyl ester H‐Val‐Tyr‐Ile‐His‐Pro‐Phe‐OCH2C6H5Paper no. II:C. Schattenkerk, G. Heymens Visser, K. E. T. KerlingandE. Havinga, Rec. Trav. Chim.83, 677 (1964). The L‐ and D‐nitrohomoarginine used were prepared by nitroguanidation of L‐and D‐lysine with nitromethylisoureaN. Heyboer, G. Heymens VisserandK. E. T. Kerling, ibid.81, 69 (1962.For the synthesis of the octapeptides, the first of which had been prepared earlier bySchwyzer et al.using a different methodW. Rittel, B. Iselin, H. Kappeler, B. RinikerandR. Schwyzer, Helv. Chim. Acta40, 614 (1957)., Z‐Arg(NO2)‐Val‐Tyr‐Ile‐His‐Pro‐Phe‐OCH2C6H5was decarbobenzoxylated by hydrobromic acid in acetic acid and the resulting heptapeptide benzy

ISSN:0165-0513    

DOI:10.1002/recl.19640830706

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractCyclisation of ψ‐ionone with deuterated sulfuric acid at 10° yields β‐ionone, deuterated in such positions as to indicate a predominant reactionviaα

ISSN:0165-0513    

DOI:10.1002/recl.19640830707

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractAromatic secondary amines giveC‐trityl derivatives under conditions under which aromatic primary amines giveN‐trityl derivati

ISSN:0165-0513    

DOI:10.1002/recl.19640830708

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractA new synthesis of 9‐oxodec‐2‐enoic acid, using thiophen as one of the starting materials, is desc

ISSN:0165-0513    

DOI:10.1002/recl.19640830709

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractFrom the extracellular lipids produced byRhodotorula Glutinis, β‐hydroxy‐palmitic acid was isolated. The structure of this acid was established by NMR and confirmed by synth

ISSN:0165-0513    

DOI:10.1002/recl.19640830710

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractAlthough substitution of chlorine usually occurs in the interaction of chloranil with aliphatic amines, solutions of chloranil in pure triethylamine yield a product which appears to be a salt, the anion of which is the free radical semiquinone ion derived from chloranil. In acetone solution this salt decomposes to yield 2,3,5‐trichloro‐6‐(2′‐diethylaminovinyl)‐p

ISSN:0165-0513    

DOI:10.1002/recl.19640830711

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY