ISSN:0165-0513    

DOI:10.1002/recl.19861051202

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractThe pentamer L‐CAAGG was prepared starting from properly protected β‐L‐ribonucleosides via a phosphotriester approach. The identity and chiral purity of the pentamer were established by1H NMR and CD spectroscopy, respec

ISSN:0165-0513    

DOI:10.1002/recl.19861051203

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractStarting from D‐ribose and 3,4‐xylidine, a fifteen‐step synthesis is described for the preparation of 5‐dFAD (18). The synthesis involves as key intermediates, 5‐deazariboflavin (8), its 2′,3′,4′‐tris‐O‐(tetrahydropyranyl) derivative (12) and 2′,3′,4′‐tris‐O‐(tetrahydropyranyl)‐5′‐O‐(mor

ISSN:0165-0513    

DOI:10.1002/recl.19861051204

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractCesium‐assisted benzylation of morphine (1) gave 3‐O‐benzylmorphine (3) in high yield, leading to a convenient synthesis of 3‐benzyloxy‐7,8‐didehydro‐4‐methoxy‐N‐methylmorphinan‐6‐one (8). This was accomplished byOppenaueroxidation of3, followed by 4,5α‐epoxy ring opening and methylation, respectively. The key step in this sequence,viz.the reductive epoxy ring opening with retention of the 7,8‐double bond, could also be applied to codeinone (4) giving quantitatively thebainone‐A (6). The low‐yield synthesis of3involving a classical procedure can be explained by theHofmanndegradation products16and17.The morphinan‐5,7‐diene14was obtained from8via thep‐toluenesulfonylhydrazone13.Morphinan‐6,8‐dienes

ISSN:0165-0513    

DOI:10.1002/recl.19861051205

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractCationic cyclization of 2‐[6‐(m‐methoxyphenyl)‐5‐(methoxymethyl)‐(E)‐3‐hexenyl]‐3‐ methyl‐2‐cyclopentenol23aand of the phenylmethoxymethyl analogue23bhas been studied. Although oxygen participation with the cyclization by the ether group is possible, and was observed, cyclization to steroids remains the major pathway.The decreased stereoselectivity, when compared with the cyclization of the 7‐methyl analogues, may be due to the occurrence of bo

ISSN:0165-0513    

DOI:10.1002/recl.19861051206

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

Abstract4,5α‐Epoxy‐3‐methoxy‐8β‐nitro‐6β, 14β‐ethenomorphinan (5) was isolated as one of two major cycloaddition products of 6‐demethoxy‐17‐formylnorthebaine (3) and nitroethene. Structure elucidation was mai

ISSN:0165-0513    

DOI:10.1002/recl.19861051207

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractThe structure of the title compound was determined by X‐ray analysis, using CuKα radiation, graphite crystal monochromator, λ=1.5418 Å, C17H16, Mr=220.31, monoclinic, space group P21, a=9.0270(9), b=9.5267 (16), c=8.0327(6) Å,β=112.366(7)°, V=638.8 Å3, Z=2, Dc=1.145 Mg/m3, μ(MoKα)=4.92 cm−1, F(000)=236.0, T=290 K. Final conventional R‐factor = 0.044, Rw=0.063 for 2222 unique reflections and 201 variables. The structure was so

ISSN:0165-0513    

DOI:10.1002/recl.19861051208

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractThe structure of the title compound was determined by X‐ray analysis, using MOKα radiation, graphite crystal monochromator, λ=0.71069 Å, C18H22N2O3. 1/6 CH2Cl2, Mr=376.53, monoclinic, space group P21/c, a=12.297 (11), b=17.781(6), c=16.612(3) Å,β=93.91(3)°, V=3624(3) Å3, Z=8, Dc=1.35 Mg/m3, μ(MoKα)=1.6 cm−1, F(000)=1399.0, T=290 K. Final conventional R‐factor = 0.096, Rw=0.119 for 3060 unique reflections and 419 variables. The structure was solved by an orientation and translation search on a known fragment and expand

ISSN:0165-0513    

DOI:10.1002/recl.19861051209

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19861051201

出版商:WILEY‐VCH Verlag    

年代:1986

数据来源: WILEY