ISSN:0165-0513    

DOI:10.1002/recl.19650840702

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractThe possibility of the existence of an equilibrium in diethyl ether between ethylmagnesium bromide ‐ prepared from14C‐labelled ethyl bromide and magnesium ‐ and diethylmagnesium was investigated. The result was inconclusive because complete exchange of ethyl groups was found which might be attributed either to the existence of an equilibrium or to a transmetallation rea

ISSN:0165-0513    

DOI:10.1002/recl.19650840703

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractTwo ester‐phosphonate analogs of cephalin of the type(I)have been synthesized in theL‐dipalmitoyl (R  C15H31) andDL‐distearoyl (R  C17H35) forms. 2‐Phthalimidoethylphosphonic acid was prepared by hydrogen bromide cleavage of its crude diethyl ester. Reaction ofD‐αβ‐dipalmitin orDL‐αβ‐distearin with 2‐phthalimidoethylphosphonyl dichloride gave, after hydrazinolysis and purification of the product on a silicic acid column, the corresponding phosphono‐cephalins (I).A diether‐phosphonate analog of cephalin,was prepared in high yield by condensation ofwith 2‐hydroxyethylphthalimide and trichloroacetonitrile, followed by hydrazinolysis of the pht

ISSN:0165-0513    

DOI:10.1002/recl.19650840704

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19650840705

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractThe synthesis of some 6‐dehydro‐8α,10α‐steroids from 10α‐ergosterol (pyrocalciferol) is described. 17β‐Hydroxy‐8α,10α‐androsta‐4,6‐dien‐3‐one (XI) has also been prepared from 17β‐hydroxy‐10α‐

ISSN:0165-0513    

DOI:10.1002/recl.19650840706

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractThe synthesis is reported of 20α‐hydroxy and 20β‐hydroxy‐9β,10α‐pregna‐4,6‐dien‐3‐one and their corresponding 6,7‐dihydro derivatives. The assignment of the configuration at C‐20 is based on alternative synthesis by Baeyer‐Villiger oxidation of the corresponding 20‐formyl compounds. Molecular rotation relationships and N

ISSN:0165-0513    

DOI:10.1002/recl.19650840707

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractThe synthesis and properties are described of some 6‐halo‐9β,10α‐pregnane and 6‐halo‐9β,10α‐androstane derivatives containing the 4‐en‐3‐one system. Halogenation at position 6 is accomplished by reaction of the 3‐acetoxy‐3,5‐dienes with perchloryl fluoride, chlorine, bromine orN‐bromosuccinimide. At the fluorination 6‐hydroxy compounds are obtained as by‐products, the structures of which are proved by alternative synthesis and by conversion into related compounds. The spectral data are discussed in connection with the structural assignments of the 6‐substituents. Th

ISSN:0165-0513    

DOI:10.1002/recl.19650840708

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19650840709

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractAdditional chemical shifts of the 18‐ and 19‐methyl protons in four 9,10‐stereoisomeric steroid series are determined. Differences between the values derived for steroids with the 8β,9β,10α‐, the 8β,9β,10β‐, the 8α,9α,10α‐ and those with the natural configuration are discussed. The synthesis of some 9β‐steroid hormone analogues and of pregnanes and androstanes, isomeric at C‐8, C

ISSN:0165-0513    

DOI:10.1002/recl.19650840710

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractThe synthesis is described of 6‐methyl‐9β,10α‐4‐en‐3‐ones, which were dehydrogenated to some of their 1‐dehydro, 6‐dehydro and 1,6‐bisdehydro derivatives. N.M.R. spectra reveal that ring B in 6α‐methyl‐9β,10α‐4‐en‐3‐ones has a boat conformation. The factors forcing ring B into a boat form are discussed. A summary

ISSN:0165-0513    

DOI:10.1002/recl.19650840711

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY