摘要:

Abstract8‐Sulfamoyltheophylline (V) was prepared by oxidative chlorination of 7‐benzyl‐8‐mercaptotheophylline, followed by amidation and debenzylation.This compound, built up from two diuretic principles, appeared to have no diuretic properties. On the other hand the intermediate 7‐benzyl‐8‐sulfamoyl‐theophylline exhibited an appreciable diuretic activity, while lacking the other pharmacological properties of theophylline. In addition this compound inhibited carbonic anhydrase. On the basis of these findings the synthesis was undertaken of a number of other 7‐substituted 8‐sulfamoyltheophyllines.The present report deals with the preparation of these heterocyclic sulfonamides, derived from V by the introduction of alkyl, aralkyl and aryl group

ISSN:0165-0513    

DOI:10.1002/recl.19640831202

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19640831203

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractThe measurement of the vapour pressure as a function of the temperature of a number of equilibria in the above‐mentioned system is described. The vapour pressures found may be expressed as follows:The three‐phase equilibrium S NbOCI 3− S Nb 2O 5‐ G: log Patm= ‐ 73.4680 + 27.0705· log T ‐ 0.0030359 T (610‐701.5°K.The three‐phase equilibrium S Nb 2O 5‐ L ‐ G: log Patm= 7.4229 ‐ 4193.4/T (701.5‐716°K.The three‐phase equilibrium S NbOCl 3‐ L ‐ G: log Patm= 313.0179 ‐ 15664.84/T ‐ 112.9694· log T + 0.0460236 T (530‐695°K.The two‐phase equilibrium NbCl5(L ‐ G): log Patm= 56.5395 ‐ 5494.8/T ‐ 17.7882· log T + 0.0044913 T (540‐715°K.For the situation of the qu

ISSN:0165-0513    

DOI:10.1002/recl.19640831204

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractFrom the study of the distribution ofo‐chloroaniline between petroleum ether and aqueous solutions of sodium chloride, at5,15, 25 and 35°, the activity coefficients of the free amine, under these conditions, were calculated.The dissociation constant ofo‐chloroaniline hydrochloride was determined under the same conditions using the distribution method. The ratio of the activity coefficients of hydrogen ando‐chloroanilinium ions was calculated for each case. The relationship between pK and salt molality was s

ISSN:0165-0513    

DOI:10.1002/recl.19640831205

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19640831207

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractCertain metal ions, in particular Co2+, Ni2+and Cu2+were found to increase the yield of formaldehyde at the expense of glycol during the radiolysis of methanol. The activities of the divalent first‐row transition metal ions correlate strikingly with the effect of these metal ions upon the quenching of triplet anthracene as measured byLinschitzandPekkarinen.Both effects are ascribed to rapid complex formation between the metal ions and the· CH2OH radicals or triplet anthrace

ISSN:0165-0513    

DOI:10.1002/recl.19640831208

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractThe synthesis of isopelletierine from Δ1‐piperideine and acetoacetic acid was investigated in the pH region 1 to 12. Paper chromatography was used to analyze the reaction mixtures. Depending on reaction time fair to good yields were obtained over the pH range 2 to 12. The experimental data are discussed in the light of two mechanisms proposed bySchöpf et

ISSN:0165-0513    

DOI:10.1002/recl.19640831209

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractDiether‐phosphonate analogs of phosphatidic acids of the type ROCH2‐CH(OR′)CH2P(O)(OH)2(RC2H5,R′CH3;RC18H37,R′C16H33;RC18H37,R′CH3) have been prepared by reaction of the corresponding iodides with triethyl phosphite, followed by hydrolysis. The iodides were prepared in one step from the allyl alkyl ether, alcohol, iodine, and zinc oxide. It was found that a reagent recently described for the detection of phosphatides on thin‐layer chromatograms also detects many but not all phosphonic acids and esters. The synthesis of propargyl octadecyl ether and of barium ethyl 2‐benzyloxyethylph

ISSN:0165-0513    

DOI:10.1002/recl.19640831210

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0165-0513    

DOI:10.1002/recl.19640831211

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractThe investigations ofBéhaland other authors (loc. cit.) have led to the generally accepted view that the esterification of alcohols with the formic acid/acetic anhydride reaction mixture leads to the exclusive formation of formates. A reinvestigation, however, has shown that under the conditions used byBéhal, acetates are also produced. Generally, the amounts of acetates formed decrease in the order primary, secondary, tertiary alcohols; in the last case acetates are formed to a negligible degree. This finding leads to a simple and convenient method for the preparation of pure tertiary alkyl formates in high yields. The results obtained are discussed in relation to conflicting literature data as regards the synthesis of formate

ISSN:0165-0513    

DOI:10.1002/recl.19640831212

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY