ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00618.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract.Physical fitness and leisure time physical activity are strongly correlated, and both are inversely correlated with risk of ischaemic heart disease. Does this mean, however, that a very fit man has a lower risk of ischaemic heart disease (IHD), even if he is inactive? And does it also mean that an unfit, but active man, doesnothave a lower risk of IHD than an unfit, inactive man? In the Copenhagen Male Study, we analysed the joint effect of fitness and leisure time activity. In 1970/71, 4999 men aged 40–59 years, were classified according to level of physical fitness, i.e. indirectly measured maximal oxygen uptake, and physical activity, and their mortality was recorded over the following 17 years. In sedentary men, fitness was no predictor of future risk of IHD whatsoever. Age‐adjusted baseline values were similar in later IHD cases and survivors (32.3 and 32.1 ml O2kg−1min−1, respectively;P= 0.91). In medium or highly active men, however, fitness was a strong predictor. The corresponding fitness values were 33.1 and 34.8 ml O2kg−1min−1(P<0.001). The least fit (two least fit quintiles) physically active men had a lower IHD mortality rate (6%) than the least fit sedentary men (10%). Adjusted for age, social class and smoking in a multiple logistic regression equation, this was estimated to an RR (95% C.I.) of 1.67 (1.06‐2.64) (P= 0.027). The two major new findings of this study were (a) that being very fit, provides no protection against IHD—nor all‐cause mortality—in sedentary men, and (b) that unfit but sedentary men have a higher risk of IHD than unfit but active men, i.e. those performing light physical activity for at

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00619.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract.In a cohort of 3383 men aged 53 to 74 in the Copenhagen Male Study we investigated the association between ischaemic heart disease (IHD) and the Lewis blood group, assigned to chromosome 19. Among men with the Le(a ‐ b ‐) phenotype, 8% had a history of non‐fatal myocardial infarction, among others the frequency was 4%. The corresponding odds ratio was (95% confidence interval: CI) 1.9 (1.2–3.0)P<0.01. men with Le(a ‐ b ‐) had a risk‐factor profile and pattern of disease resembling that of Reaven's syndrome X. In a subsequent prospective study 343 men with arteriosclerotic stigmas were excluded. The men had their morbidity and mortality recorded over the next 4 years. One‐hundred‐and‐one men suffered IHD; 26 dying from IHD. In total 162 men died. Men with Le(a ‐ b ‐) had an increased risk of death from IHD compared with others. Adjusted for age, relative risk (RR) (95% CI) was: 4.4 (1.9–10.3),P<0.001, and for all causes of mortality: RR = 1.6 (1.0–2.6),P<0.05. Men with the Le(a‐b‐) phenotype had an increased risk of an IHD event compared to men with other phenotypes (RR = 1.6 (0.9‐2.8),P= 0.10) and a significantly higher IHD case fatality rate (RR = 2.8 (1.5‐5.2),P= 0.0]). The finding that the Le(a‐b‐) phenotype is a genetic marker of IHD risk may have implications in terms of prevention. The Le(a‐b‐) phenotype may also contribute to providing an explanation for the substantial ethnic differences found in the incidence of IHD. The similar risk‐factor profile and pattern of disease found between Le(a ‐ b ‐) men and individuals with Reaven's syndrome X is hypothesized to be due

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00620.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract.Lipids and lipoprotein levels were determined in the plasma of 20 adult hypertensive patients, after 12 weeks treatment with amlodipine. No significant variation was observed in the mean values of the lipids and lipoprotein fractions before and after amlodipine treatment for the patients on either 5 mg or 10 mg of amlodipine. A further long‐term study has been suggested in order to confirm the inertness of amlodipine on lipids and lipoprotein metabolis

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00621.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract.Fifteen patients presented between January 1986 and January 1991 with deterioration in renal function coincident with the introduction of angiotensin converting enzyme inhibitors. There was evidence of extrarenal vascular disease in 12 patients and preexisting renal impairment in 13. Four patients remained dialysis‐dependent and died within 4 weeks of presentation. Five patients required short‐term dialysis. Serum creatinine remained above pre‐treatment values in seven patients. Conventional explanations of the decline in renal function with ACE inhibition do not account for irreversible decrements in renal function. Possible mechanisms for this observation and clinical guidelines to identify patients at risk are suggested. We conclude that these agents should be used with great care in patients in whom atherosclerotic vascular disease is l

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00622.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract.The purpose of this study was to estimate the prevalence of hypertrophic cardiomyopathy (HCM) in 3607 men from the Reykjavik study of 1979‐81. Of these, 452 men had an abnormal (group A) and 3155 a normal electrocardiogram. An echocardiographic control group of 128 men was selected from cohorts with a normal electrocardiogram (group B). Until 1987, 189 deaths had occurred, 59 from group A and 130 from cohorts with a normal ECG including 4 from group B. To identify subjects with HCM, survivors of groups A and B were examined by echocardiography and by review of all autopsy data and death certificates. HCM was found in 14 subjects from group A but none in group B. Two additional cases were found at autopsy in cohorts with a normal ECG.The prevalence of HCM in men with an abnormal and normal ECG was 3.6% and 0.8%, respectively. The overall prevalence was calculated to be 1.1% with a 95% confidence interval of 0.3‐3.2%. Men with HCM reported more symptoms than others in groups A and B (P<0.05‐0.001), 25% were without symptoms. Asymptomatic ventricular arrhythmias were detected by Holter monitoring in 45% of men with HCM. The total annual mortality was 1.6% compared with 0.5% in the group with a normal ECG (P<0

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00623.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00624.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00625.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00626.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1992.tb00627.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY