ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00069.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00070.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.In order to investigate the potential role of atrial natriuretic peptide (ANP) in mild to moderate essential hypertension, a study was conducted in groups of normotensive and hypertensive middle‐aged men born in 1926 and 1927. Venous plasma concentrations of immunoreactive ANP (irANP) were studied in relation to measurements of cardiac structure and function, urinary electrolytes as well as some cardiovascular hormones. Plasma irANP did not differ between normotensive controls (31 ± 14 pmol l−1) and borderline or untreated hypertensive patients. However, irANP concentrations were slightly but significantly (P<0.05) lower in the borderline (26 ± 8 pmol l−1) compared to the untreated established hypertensives (35 ± 14 pmol l−1). No relationships were found between irANP and blood pressure, indices of left ventricular structure and function or hormone parameters in subgroups or the whole study group.Our data do not support the view that plasma irANP is increased in uncomplicated essential hypertension, since our groups of borderline or established hypertensive middle‐aged men without major cardiac involvement did not differ in irANP concentrations compared to normotensive controls. Thus, during the development or in the early stages of essential hypertension, ANP secretion does not seem to

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00071.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.The interaction between felodipine and digoxin was studied after a single oral dose and at steady state in 14 patients with congestive heart failure. Felodipine (10 mg) was randomly given as an extended release (FER) tablet in a double‐blind, placebo‐controlled, cross‐over fashion. In addition, felodipine (10 mg) was given openly as a plain tablet, following the double‐blind period. Each period lasted for 7 d. Felodipine ER did not alter the pharmacokinetics of digoxin when given as a single dose or at steady state compared with placebo. At steady state the felodipine plain tablet resulted in an 11% increase (P<0.05) in peak plasma concentrations of digoxin. Systolic time intervals as noninvasively measured haemodynamic parameters were not significantly altered following the felodipine ER period, while the felodipine plain tablet significantly decreased the preejection/left ventricular ejection time ratio compared to

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00072.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.During treatment with tolbutamide 10 maturity onset diabetic patients had no detectable activity of tissue‐type plasminogen activator (t‐PA) determined on two occasions 3 months apart. All 10 patients responded on the change in treatment to gliclazide with an increase in activity of t‐PA. However, after 12 months of treatment the t‐PA activity in one of the 10 patients returned to the baseline level, whereas the remaining nine patients had a sustained increased t‐PA activity compared to the period during treatment with tolbutamide. The concentration in plasma of t‐PA antigen under basal conditions and after stimulation (venous occlusion) increased significantly during the period of treatment with gliclazide. The plasma concentrations of plasminogen activator inhibitor remained unchanged throughout the study. In contrast to these findings seven patients with marked activities of t‐PA during treatment with tolbutamide retained unchanged levels of the variables reported above after a change in treatment to gliclazide.Serum glucose, HBA1c, apolipoproteins A and B, and triglycerides remained constant throughout the study, whereas serum cholesterol showed a decrease in both groups of patients after 3 months (P<0.05) as well as after 12 months (P<0.05) of treatment with gliclazide. There was no significant relationship between serum cholesterol concentrations and plasma concentrations of t‐PA antigen indicating that the increase in t‐PA antigen was independent of the metabolic stat

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00073.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.The prevalence of hereditary haemochromatosis (HH) was studied in Stockholm and Göteborg, the two largest cities in Sweden, using screening with transferrin saturation in combination with serum ferritin and further clinical and laboratory examinations. In Göteborg, none of 1660 men aged 50 and 51 years, randomly selected from the census register, was found to have HH. In Stockholm, nine out of 11920 male hospital inpatients were diagnosed as having HH. The calculated mean and 95% confidence ranges were consistent with earlier findings in two studies on men in Malmö, the third largest urban area in Sweden. Pooling results from these three main urban areas, the mean prevalence was 0.073% (17/23, 355), which is considerably lower than figures reported from one area in northern Sweden and from pedigree analyses in several other areas in the world. Screening of the US population in the N‐HANES II study also showed much lower figures. The reasons for these discrepancies are discussed and it is suggested that the average prevalence of HH in Caucasian populations is probably around 0

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00074.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.Marked circadian variations in the activated partial thromboplastin time (APTt) during continuous heparin infusions for thromboembolic episodes have been reported in a French study. The aim of the present study was to test if these variations could be reproduced in a Swedish population. The frequency spectrum variations in APTt values were analysed with the Prony and the statistical Pearson product momentum correlation coefficient methods. In seven patients with pulmonary embolism, APTt was checked every fourth hour during 48 h of continuous, constant heparin treatment. In only one patient was a distinct circadian variation of APTt values seen. In six patients with venous leg thromboses, treated with s.c. heparin, marked variations in APTt were noticed over periods of 12 h. These variations paralleled the regular s.c. injections of heparin every twelfth hour. The results of the present study could not confirm the marked circadian variations in APTt reported in an earlier French study during continuous heparin infusions, except in one patient.

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00075.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.The orifice area was non‐invasively assessed in 19 patients with mitral or mitral and tricuspid stenosis by combined cross‐sectional and Doppler echocardiography. Stroke volume was calculated as the product of aortic or pulmonic cross‐sectional area and the time velocity integral of the flow across that valve, and the stenotic valve area was obtained as the stroke volume divided by the time velocity integral of the stenotic valve. In addition, the mitral valve area was estimated by the pressure half‐time method of Hatleet al. The non‐invasive determinations were compared with those calculated by the Gorlin formula at cardiac catheterization.The valve area obtained by combined cross‐sectional and Doppler echocardiography showed a close correlation with the Gorlin area,r= 0.90, SEE = 0.13 cm2,n= 20. In contrast, the valve area estimated by the pressure half‐time method showed only a moderate correlation with the Gorlin area,r= 0.68, SEE = 0.38 cm2,n= 18. and estimates by this method tended to significantly overestimate the Gorlin area.In conclusion, non‐invasive valve area determinations based on combined cross‐sectional and Doppler echocardiography can be used to accurately quantify the severity of the lesion in patients with atrioventricular valve stenosis, while determinations by the pressure half‐time method may show errors of a magnitude that limits its cli

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00076.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.Cardiac volume (CV) was measured and indices of pulmonary congestion (PCG) were judged from routine chest films taken post myocardial infarction (AMI) in a consecutive series of 477 patients (340 first and 137 recurrent AMIs). Cardiac volume (CV) and signs of PCG were compared to left ventricular ejection fraction (LVEF), measured with isotope technique, and the prognostic value of all the parameters was assessed after 1 and 5 years. The accuracy of CV and PCG in predicting impaired LVEF was low (62% and 50% respectively). Although specificity is suboptimal, however, these parameters provided valuable prognostic information. For example, patients with signs of PCG had a very high 1 and 5 years' mortality, and two‐thirds of those who died during the first year of observation had enlarged CV. The independent value of LVEF determination was mainly observed in re‐AMI patients. A more restricted use of this expensive procedure may therefore be recommen

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00077.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.IGF‐I and IGF‐II as well as the low molecular type of IGF binding protein (IGFPB) were determined in serum from 11 adolescents with insulin‐dependent diabetes mellitus (IDDM) during a cross‐over study with conventional and continuous subcutaneous insulin infusion (CIT and CSII) therapy. At the onset of the study the mean IGF‐I level, 127 ± 15 ng ml−1, was significantly decreased (P<0.001) in comparison with age‐matched controls, whereas the mean IGF‐II level, 1024 ± 48 ng ml−1. was increased. A significant correlation (r= 0.70,P<0.05) was found between IGF‐II and HbA1c levels. The mean morning level of IGFBP, 75 ± 17 ng ml−1, at the onset of the study, was increased threefold above that in age‐matched controls (P<0.01). There was a significant correlation between IGFBP and blood glucose values (r= 0.66,P<0.05). During CSII therapy a significant decrease (P<0.05) of the IGFBP levels was seen in subjects with a decrease in glucose levels, whereas no change was observed in IGF levels.The findings of elevated IGF‐II and IGFBP levels and correlations between IGFBP and blood glucose concentration as well as IGF‐II and HbA1c levels in adolescents with IDDM indicate that both IGF‐II and IGFBP reflect a deranged metabolism caused by i

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00078.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY