ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00027.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.The serum concentrations of IgG, IgA, IgM and of the four subclasses of IgG were determined by radial immunodiffusion in 103 patients, mean age 42 (range 16–72), with various types of glomerulonephritis. Forty‐nine healthy blood donors, mean age 41 years (range 19–65), served as controls. Kidney biopsies were obtained from all the patients for examination by histopathology and by immunofluorescence. The glomerulopathies were classified according to WHO criteria.The serum immunoglobulin patterns were different for the various clinical groups of patients. Patients with Wegener's granulomatosis, rapidly progressive glomerulonephritis and SLE had a significant increase in total IgG and of IgG4(P<0.05–0.001). Patients with minimal change disease had low concentrations of IgG (P<0.001) with a significant decrease in IgG1and IgG2(P<0.001 and 0.01. respectively). Highly significant increases in IgA were noted for patients with IgA nephritis (P<0.001) but high levels were also seen in patients with chronic glomerulonephritis. The findings might have diagnostic impli

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00028.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.A prospective study was carried out in 499 patients admitted to a coronary care unit (CCU) in order to evaluate the incidence of clinically significant electrolyte disturbances. Low serum potassium values (<3.6 mmol l) occurred in 7% of the CCU patients and low serum magnesium values (<0.70 mmol l−1) in 6%. Few patients had low values of both these ions (1.9%). In 49 patients the contents of these electrolytes in muscle biopsies were similar to the values of control subjects and were unrelated to treatment with diuretics. Serum calcium was determined in 444 of the patients and was above the reference range in 11 (2.5%). If we consider their concomitant parathyroid hormone (PTH) values, primary hyperparathyroidism was likely to occur in at least seven patients (1.5%). Patients with acute myocardial infarction (AMI) had mean PTH and electrolyte values similar to those of individuals without this disease. In conclusion, the present study indicates that clinically important disturbances of magnesium, potassium or calcium homeostasis are rare among unselected patients admitted to a CC

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00029.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.To evaluate the influence of an infective agent, severity of infection and the age of the patient on infection‐induced glucose intolerance, concentrations of fasting blood glucose, serum insulin (n= 31) and plasma glucagon (n= 22) were measured and the oral glucose tolerance test (OGTT) was carried out (n= 26) during acute and convalescence phases and after complete recovery in patients with viral (n= 17) or bacterial (n= 14) infections. Serum insulin was increased (P<0.001) but plasma glucagon was decreased (P<0.01) both during acute infection and the convalescence period. In the acute stage, 2‐h values of blood glucose (P<0.01) and serum insulin concentrations (P<0.001) during OGTT were elevated. The index of insulin resistance (glucose x insulin) was increased by 33% during infection and by 28% during convalescence (P<0.001). The observed changes did not correlate with the severity of infection, were more pronounced in younger patients than in older ones and were not dependent on the infective agent. It is clinically important to recognize that the restoration of insulin sensitivity takes longer than the immediate recovery period from the infect

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00030.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.Two patients with life‐threatening disseminated intravascular coagulation (DIC) syndrome, one caused by Gram‐negative bacteria and one by premature separation of the placenta, are described.Specific substitution was given by antithrombin III concentrate and AHF‐Kabi, a low purity factor VIII concentrate containing native von Willebrand factor and factor XIII. The treatment quickly returned the extremely low levels of antithrombin III, factor VIII; C, fibrinogen and factor XIII, initially found, to normal, and also returned the multimeric pattern of von Willebrand factor to normal. This resulted in diminished bleeding, enabling surgical treatment of the underlying di

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00031.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract.Preliminary experience of the efficacy and safety of a new regenerating system for selective extracorporeal removal of apolipoprotein B‐containing lipoproteins is described. Four patients with familial hyperlipoproteinaemia were studied on 10 occasions. A system of two, parallel, dextran sulphate cellulose columns was used, and plasma was processed continuously by passage through one of the columns while the other was being regenerated. With this procedure, reductions of very low density and low density lipoprotein cholesterol levels by 73 and 43%, respectively, could be achieved after treatment for 2.5–3 h (1000–3200 ml of plasma volume). No clinically relevant changes in the concentrations of other plasma proteins, including high density lipoproteins, were observed, and the treatment was well tolerated. We conclude that continuous selective apolipoprotein B apherisis is a safe and efficient lipid‐lowering procedure which may be used both for metabolic investigations and for studies on possible regression of atherosc

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00032.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00033.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00034.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00035.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0954-6820    

DOI:10.1111/j.1365-2796.1989.tb00036.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY