摘要:

The efficacy of two S-HT1Areceptor agonists in drug-naive and benzodiazepine-experienced rats was compared in two animal vests of anxiety, the social interaction and elevated plus-maze tests. Benzodiazepine-experienced rats were tested 48 h after the last of 28 daily injections of diazepam (2mg/kg/day), a time at which there was no anxiogenic withdrawal response. S 20499 (0.04, 0.2 and 1 mg/kg) ((+)-8(4–[N-(5-methoxychroman-3yl)N-propylamine]butyl)-8-azaspiro[4,5]decane-7,9-dione) and buspirone (0.2 mg/kg) significantly increased social investigation, indicating anxiolytic-like actions, and there was no significant modification in these effects as a result of the previous diazepam treatment. Both drugs also significantly reduced aggressive behaviours in both drug-naive and diazepam-experienced rats. An anxiolytic-like action in the elevated plus-maze was also indicated for S 20499 (0.04 and 0.2 mg/kg) by an increase in the percentage of time spent on the open arms; this effect was not significantly changed by prior diazepam experience. Buspirone (0.2mg/kg) had no significant effects on the plus-maze. The results provide no evidence for reduced efficacy of 5-HT1Areceptor agonists in animal tests of anxiety as a result of prior diazepam treatment.

ISSN:0955-8810    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The abuse of anabolic-androgenic steroids noted in recent years has been correlated with an increased likelihood of abuse of other drugs, including cocaine. This research was designed to investigate whether manipulation of androgen levels would alter the unconditioned behavioral effects of cocaine. The influence of testosterone on the locomotor activating effect of oral cocaine was evaluated. Subjects were male gonadally intact and castrated Wistar rats, implanted s.c. with either placebo or 100 mg testosterone 30-day pellets. Beginning 7 days after pellet implantation, each animal in the four subgroups randomly received 0, 20, 40 and 80 mg/kg cocaine (once, each dose). Cocaine 80 mg/kg significantly enhanced locomotor activity in all groups except the intact testosterone-treated group. Of the four groups, this subgroup would have the highest plasma level of testosterone. These data suggest that chronic exogenous androgen administration may reduce the behavioral effects of cocaine.

ISSN:0955-8810    

出版商:OVID    

年代:1994

数据来源: OVID