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| 11. |
Pharmacokinetics of antipyrine, acetaminophen and lidocaine in fed and fasted horses |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 73-82
L. R. ENGELKING,
G. T. BLYDEN,
J. LOFSTEDT,
D.J. GREENBLATT,
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摘要:
Engelking, L.R., Blyden, G.T., Lofstedt, J.&Greenblatt, D.J. Pharmacokinetics of antipyrine, acetaminophen and lidocaine in fed and fasted horses.J. vet. Pharmacol. Therap.10, 73–82.Previous studies demonstrated that plasma clearance of organic anions such as bilirubin, bile acid, sulfobromophthalein (BSP) and indocyanine green (ICG), was reduced from 36% (bile acid) to 55% (ICG) in fasted (3 days) horses. It is believed that a general decline in carrier‐mediated hepatic uptake may have accounted for those changes. However, fasting may also affect hepatic blood flow, thereby contributing to reduced clearance of these compounds. In order to test this hypothesis, plasma clearance of antipyrine, acetaminophen and lidocaine, drugs known to be cleared by the liver yet not suspected of undergoing carrier‐mediated hepatic uptake, were investigated in nine healthy adult mares (three horses/drug group) before and following a 3‐day fast. Results demonstrate that fasting decreased clearance of organic anions from previous studies more than clearance of drugs used in these studies. In addition, clearance of lidocaine, the drug with the highest plasma clearance and therefore the drug most likely to be affected by reduced hepatic blood flow, was affected least by fasting. Therefore, reductions in clearance of these compounds due to fasting must not be due entirely to reductions in hepatic blood flow, but must also involve reductions in intrinsic hepatic cl
ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00079.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 12. |
Pharmacokinetics of sulphaphenazole in cattle |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 83-84
S. A. ØDEGAARD,
A. RÅSTAD,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00080.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 13. |
The use of plastic rings to determine the dimensions of ocular inserts for insertion into the conjunctival sac of cattle |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 85-89
P. I. PUNCH,
C. D. HAWKINS,
D. H. SLATTER,
N. D. COSTA,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00081.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 14. |
Effect of different intervals between dosing and feeding on systemic availability of penicillin V in dogs |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 90-95
A. D.J. WATSON,
D. R. EMSLIE,
I. C. A. MARTIN,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00082.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 15. |
Response to physostigmine administration in collie dogs exhibiting ivermectin toxicosis |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 96-100
W.J. TRANQUILLI,
A.J. PAUL,
R. L. SEWARD,
K. S. TODD,
J. A. DIPIETRO,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00083.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 16. |
Plasma concentration of gentamicin after intramuscular or subcutaneous administration to horses |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 101-103
J. M. GILMAN,
L. E. DAVIS,
CAROL A. NEFF‐DAVIS,
G. D. KORITZ,
G.J. BAKER,
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PDF (220KB)
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00084.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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| 17. |
Notice |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 10,
Issue 1,
1987,
Page 104-104
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1987.tb00085.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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