11. |
The effects on the pharmacokinetics of intravenous ceftiofur sodium in dairy cattle of simultaneous intravenous acetyl salicylate (aspirin) or probenecid |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 61-67
T. WHITTEM,
D.A. FREEMAN,
D. HANLON,
K. PARTON,
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摘要:
Ceftiofur sodium is a third‐generation cephalosporin antibiotic. It is possible that non‐steroidal anti‐inflammatory drugs such as acetyl salicylate (aspirin) may be used concomitantly with ceftiofur sodium in dairy cattle. Therefore this study evaluated potential pharmacokinetic interactions between ceftiofur sodium and aspirin. In addition, this study evaluated the potential for interaction between ceftiofur and its active metabolites and the organic anion transporter. The organic anion transporter substrate used in this evaluation was probenecid. Ten healthy, non‐pregnant, non‐lactating dairy cows were used in a randomized complete three‐way crossover design. In repeated experiments all cows were administered: (1) 2 mg of ceftiofur sodium per kg body weight by intravenous bolus or (2) 10 mg of probenecid per kg body weight by intravenous bolus, followed immediately by 2 mg of ceftiofur sodium per kg body weight by intravenous bolus or (3) 26 mg of aspirin per kg body weight by intravenous bolus, followed immediately by 2 mg of ceftiofur sodium per kg body weight by intravenous bolus. For treatment with ceftiofur sodium alone, the mean volume of distribution at steady‐stateVd(33)was 0.2 ± 0.06 L/kg, the mean volume of distribution by the area methodVd(area)was 0.38 ± 0.22 L/kg, mean residence time (MRT) was 6.5 ± 1.8 h, mean residence time in peripheral tissues (MRTp) was 2.6 ± 1.0 h, total body clearance (Cf) was 0.032 ± 0.013 L/kg/h and elimination rate constant (P) was 0.097 ± 0.044 h‐1(mean ± standard deviation). No statistically significant changes were detected as a result of preceding treatment with aspirin. Preceding treatment with probenecid resulted in a decrease in bothCl(0.007 ± 0.005 L/kg/h) andMRTp(0.89 ± 0.45 h). These results suggest that ceftiofur or its metabolites may interact with the organic anion transporter, but that consideration of alterations to dose and dose interval may not be necessary when ceftiofur sodium is administered to the cow concomitantly with
ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00552.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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12. |
Hyperalgesia following administration of morphine and pethidine in the root rat (Tachyoryctes splendens) |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 68-71
P.K. TOWETT,
T.I. KANUI,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00553.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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13. |
Bioavailability of benzodiazepines following rectal administration of diazepam in dogs |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 72-74
K. L. MEALEY,
D. M. BOOTHE,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00554.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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14. |
Passage of lincomycin from blood into the semen of bulls after multiple subcutaneous administration of a lincomycin‐spectinomycin combination |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 75-76
S. MARCUS,
G. ZIV,
A. GLICKMAN,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00555.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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15. |
THE VETERINARY FORMULARY. HANDBOOK OF MEDICINES USED IN VETERINARY PRACTICE |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 77-77
G. ZIV,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00556.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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16. |
Presidential address conferring Honorary Membership of EAVPT on Prof. Dr Adelbert van Miert |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 78-78
M. Debackere,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00557.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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17. |
In memoriamProf. Dr Stanislaw Garwacki |
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Journal of Veterinary Pharmacology and Therapeutics,
Volume 18,
Issue 1,
1995,
Page 79-79
M. Debackere,
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ISSN:0140-7783
DOI:10.1111/j.1365-2885.1995.tb00558.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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