摘要:

A prolonged partial thromboplastin time in a patient with systemic lupus erythematosus usually is due to a lupus anticoagulant. Antiphospholipid antibodies may be associated with thrombosis. We describe a patient with an overlap syndrome between systemic lupus erythematosus and mixed connective tissue disease who presented with a prolonged partial thromboplastin time due to a high titer of antibodies to factor VIII (acquired hemophilia). The clinical course resulted in a fatal hemorrhage, illustrating the importance of prompt distinction between lupus anticoagulants and clotting factor inhibitors.

ISSN:1076-1608    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Although the association of the phenothiazines with immunologic abnormalities is well known, reports of clinical lupus erythematosus are rare. We describe a 52-year old schizophrenic man on chronic chlorpromazine therapy who developed fever and pleuropericarditis with cardiac tamponade. Examination of the pleural and pericardial fluids showed anti-nuclear antibodies. The clinical syndrome responded to a short course of steroids and discontinuation of the chlorpromazine. Drug-induced lupus is a self-limited illness that resolves without long-term sequelae. However, patients should be observed carefully because cardiac tamponade may occur.

ISSN:1076-1608    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Calcium pyrophosphate dihydrate crystal deposition in tendon sheaths is a rare cause of acute and chronic tenosynovitis. An elderly patient with acute wrist pyrophosphate tenosynovitis and transient periarticular calcification is described.

ISSN:1076-1608    

出版商:OVID    

年代:1995

数据来源: OVID

ISSN:1076-1608    

出版商:OVID    

年代:1995

数据来源: OVID